Hannah Long
Group Leader @mrc_hgu investigating gene regulation in development & human disease
- Reposted by Hannah Long📣 Preprint alert! I am happy to share that our neural crest manuscript is now available on BioRxiv! www.biorxiv.org/content/10.6...
- Reposted by Hannah LongSS18::SSX activates Polycomb target genes without BAF ❌ Instead, transcription relies on EP300 via the SS18 QPGY domain www.biorxiv.org/content/10.6... ➡️ Coactivator targeting emerges as a new therapeutic strategy in synovial sarcoma 🎯 Team work from @banitolab.bsky.social and @uoe-igc.bsky.social
- Reposted by Hannah LongArray-CNCC: precise aggregation and arrayed plating facilitate quantitative phenotyping of human cranial neural crest cells and craniofacial disease modelling biorxiv.org/content/10.64898/20…
- 📣 I'm excited to share our latest preprint! We adapt and characterise a neurosphere-based CNCC differentiation protocol, and demonstrate utility for quantitative phenotyping and craniofacial disease modelling! 🧫 Read about Array-CNCC here: www.biorxiv.org/content/10.6... @uoe-igc.bsky.social
- This was a fantastic collaborative effort - many congratulations to first authors Ewa and Kasia! @ewaoz.bsky.social @km-milto.bsky.social And a big thank you to everyone who provided support, input and inspiration along the way.
- 🎉 Many congratulations to Kasia Milto who successfully defended her thesis last week! It was so wonderful to have Kasia as the first PhD student in the lab, and to co-supervise with Jenny Nichols. So proud! @km-milto.bsky.social @uoe-igc.bsky.social
- Reposted by Hannah LongSuper line-up of chromatin, epigenetics and gene regulation speakers coming your way from @aicc-ireland.bsky.social over the next 5 months!
- After a short break in our webinars we are delighted to be back up & running this month! First up, on Jan 30th we will be joined by @lucas.farnunglab.com from @harvardmed.bsky.social 🔬 Shortly after, on Feb 13th we will be hosting @heardlab.bsky.social from @crick.ac.uk 🧬 Registration details 👇
- Reposted by Hannah LongLatest from our lab: dx.plos.org/10.1371/jour... Congratulations to Veronika for leading this work to model cis-regulatory dynamics in F1s using single-cell allelic data
- Reposted by Hannah LongApplications for our international #PhD program open until 11th Jan. Come work with us @uoe-igc.bsky.social and @hannahlong.bsky.social to understand DNMT3B in ICF syndrome or with our wonderful colleagues. Details here: institute-genetics-cancer.ed.ac.uk/igc-graduate... #epigenetics Please repost 🙏
- Reposted by Hannah LongExcited to share our work at @natcomms.nature.com We used single cell proteomics to define the functional heterogeneity of human neutrophils in glioblastoma, finding pro and anti-tumorigenic effector states invisible to scRNAseq. SCP will revolutionise immunology, this is just the start
- Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value
- Reposted by Hannah LongAn early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost! www.biorxiv.org/content/10.6...
- Reposted by Hannah LongJASPAR 2026 is out 🎉 The new release massively expands the TF motif collections and adds a dedicated DeepLearning collection of motifs learned from deep learning models. Database: jaspar.elixir.no Paper (NAR): doi.org/10.1093/nar/... 🧵1/2
- Reposted by Hannah LongWe are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen. 1/n
- Reposted by Hannah LongDon’t miss out on this opportunity- come and join us at the Oxford Organoid Hub working under the MRC-BHF REACT programme! If you love in vitro 3D models, the ❤️ and regenerative therapies, this is for you - apply by 18 Dec @oxforddpag.bsky.social @idrm.ox.ac.uk @rdm.ox.ac.uk
- Some good news, myself and @simoesfilipa.bsky.social are advertising for a post-doctoral researcher to join us at the Oxford Organoid hub: tinyurl.com/OOHJob Come and join us to develop novel human organoid systems as part of the MRC/BHF CRE in advanced cardiac therapies.
- Reposted by Hannah LongProject 2: Use human ES cells to determine exactly how DNMT3B mutations cause ICF1 syndrome. Collaboration with @hannahlong.bsky.social: institute-genetics-cancer.ed.ac.uk/igc-graduate... Deadline 11th January 2026 This scheme is flexible if you are interested in other projects. 🧵 3/4
- Reposted by Hannah Long🚨 Multiple #PhD opportunities for lab or computational applicants. Do you want to understand the molecular basis of #epigenetic dysfunction in human disease? Come work with our group at the fantastic, collaborative @uoe-igc.bsky.social in a beautiful, liveable city. 🧵 1/4 Please repost 🙏
- Reposted by Hannah LongVery pleased to share our latest paper published in Cell: BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants: Cell www.cell.com/cell/fulltex... @cellpress.bsky.social, @cp-cell.bsky.social, @ruizhideng.bsky.social #enhancer here is a thread about our findings:
- Reposted by Hannah LongResearchers have identified gene-regulatory variants that might have contributed to Neanderthals’ beefy jaws — offering a window on how the human face developed go.nature.com/3Ke6StJ
- Congratulations!
- It's always special when you find your own paper in the table of contents of the journal 😍 "The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form www.cell.com/developmenta...
- Reposted by Hannah Long🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉 Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨ #PhD #3DGenome
- Reposted by Hannah LongJoin us for our free inaugural lecture & drinks reception. @jorisveltman.bsky.social will talk about the genetic causes of rare disorders such as reproductive disorders & Charlie Lees will tell the 20‑year story of change in IBD. More info & register👉 bit.ly/3J766hJ @cmvm-edinburghuni.bsky.social
- Reposted by Hannah LongNeanderthal DNA enhances our understanding of face development This Research Highlight showcases the work from Hannah Long @hannahlong.bsky.social, Kirsty Uttley @kirstyuttley.bsky.social, Hannah Jüllig @hannahjuellig.bsky.social and colleagues: journals.biologists.com/dev/article/...
- Reposted by Hannah LongOur latest paper has just been published in Cell! doi.org/10.1016/j.ce... We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
- Reposted by Hannah LongTo learn more about how this story developed and the researchers behind it, we talked to co-first authors Kirsty Uttley and Hannah Jüllig, as well as corresponding author, Hannah Long doi.org/10.1242/dev....
- Reposted by Hannah LongExcited to share our new paper out today in Development! Check out Hannah’s fantastic post below for a summary of the findings ✨ journals.biologists.com/dev/article/...
- 📣 Paper alert! I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today! journals.biologists.com/dev/article/...
- 📣 Paper alert! I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today! journals.biologists.com/dev/article/...
- In our previous work, we explored how chromosomal translocations and large deletions upstream of the SOX9 gene may impact facial development in patients with Pierre Robin sequence (PRS). We identified two candidate enhancers active in facial progenitor cells. doi.org/10.1016/j.stem.2020.09.001
- One of these enhancers (EC1.45) lies a huge 1.45 megabases upstream of the SOX9 gene, yet is crucial for its expression during facial formation. We reasoned that smaller genetic changes within EC1.45 may tweak its activity and cause more subtle impacts to facial shape.
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View full threadMany congratulation to first authors @kirstyuttley.bsky.social and @hannahjuellig.bsky.social who led this work. And a big thank you to co-authors, our funders and everyone who supported this project. journals.biologists.com/dev/article/... @uoe-igc.bsky.social @edinburgh-uni.bsky.social @ukri.org
- Reposted by Hannah LongWe recently reported that promoter competition can contribute to the robust insulation of gene regulatory domains (www.nature.com/articles/s41...). We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇
- Reposted by Hannah Long🥁This Wednesday , in #FragileNucleosome seminar, we are excited to host @hannahlong.bsky.social and @jeffvierstra.bsky.social to tell us about amazing work they are doing! 🗓️Register here for upcoming session and the entire series: us06web.zoom.us/webinar/regi...
- Reposted by Hannah Long⚡⚡Excited to announce I'll be starting my lab at the Max Planck Institute of Molecular Genetics (@molgen.mpg.de) in Berlin in December! Leaving sunny California to join a fantastic environment with colleagues who do super cool work. 🔬🦠I'm hiring at all levels! 🔬🦠Check: www.molgen.mpg.de/fueyo-lab
- Reposted by Hannah LongMany enhancers that drive tissue-specific gene expression are already connected to gene promoters in human pluripotent cells. In a new preprint, we share some clues about when, how, and why this happens! www.biorxiv.org/content/10.1...
- Reposted by Hannah LongFunctional maps of a genomic locus reveal confinement of an enhancer by its target gene www.science.org/doi/10.1126/...
- Looking forward to listening!
- In this episode of the Epigenetics Podcast, we talked with @em6wong.bsky.social from the University of New South Wales in Sydney about her work on how evolution shapes mammalian genes. #podcast #epigenetics #chromatin Listen here: www.activemotif.com/podcasts-emi...
- Reposted by Hannah Longdeadline tomorrow, Sept 19! www.csh-asia.org?content/2767
- Reposted by Hannah LongRESEARCH PAPER: Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function By Williamson et al. ➡️ tinyurl.com/gd352648 #chromatin #enhancer #transcription #sonichedgehog #TAD #cohesin #genomics #3Dgenome #loopextrusion
- Reposted by Hannah LongNew online! Is enhancer-driven gene regulation all wrapped up?
- Amazing evolutionary gene regulatory story about dorsoventral limb and fin patterning! Congratulations to all the team 🙌
- We take for granted that our hands have two sides and can articulate in an endless number of ways. But what about a fish’s fin? Can a fish know something “like the back of its fin,” or have its future told with a fin palm reading? Check out this bluetorial to find out 👇🧪🧬🐟 doi.org/10.1101/2025...
- Reposted by Hannah LongWe're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social! register here for the entire series: us06web.zoom.us/webinar/regi...
- Reposted by Hannah Long
If you like transcription regulation and its mechanisms, this WIP list is for you. I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list. go.bsky.app/8vTgeXBat://did:plc:y655pqb5a3etnlz62iqgck5d/app.bsky.graph.starterpack/3lxhl3qh3ay2d - Reposted by Hannah LongSuper excited that our latest work is out! We use optogenetics to dynamically control and study the formation of morphogen gradients. If you are interested in optogenetic tools and/or how cells shape and process extracellular signals, check out @jamesbriscoe.bsky.social's thread and the paper.
- Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh 🧵 www.sciencedirect.com/science/arti...
- Reposted by Hannah LongDenisovans or their close relatives identified in the fossil record using a gene regulatory phenotyping method. Now out: www.pnas.org/doi/10.1073/...
- Reposted by Hannah LongEva Nogales @nogaleslab.bsky.social introducing the 2025 CSH Mechanisms of Eukaryotic Transcription Meeting. Co-organizing with Wendy Bickmore @wbickmor.bsky.social and Joanna Wysocka. Will intermittently try to update as allowed
- Reposted by Hannah LongRegistration is still open for Transcription and Chromatin UK 2025. Join our growing research community in Manchester this September!
- Reposted by Hannah LongTo all post-docs: The Genome Biology dept @embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
- Reposted by Hannah Long👇 Highly recommend applying if you want to join a great team and work on a high-profile, inter-university project! #postdocjobs
- 📣Job Alert: We are looking for a postdoctoral researcher with hands-on experience in neural tissue culture, preferably neural organoids, for a collaborative project on Alzheimer's disease and MS between KULeuven, UHasselt and UGent in Belgium. Deadline August 31: www.ugent.be/en/work/scie...
- Reposted by Hannah Long📣 We are recruiting! Please share!! Are you a bioinformatician / computational scientist who wants to apply your skills to understanding regulatory biology and improving rare disease diagnosis and treatment? 🧠 💻 🧬 🩺 We have two roles available 👇 🧵 1/4
- Reposted by Hannah LongHappy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value
- Reposted by Hannah LongInterested in developmental epigenetics? So are we! Apply now to join us for your postdoc! Multiple positions across multiple groups @mrc-lms.bsky.social Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇 lms.mrc.ac.uk/work/vacanci...
- Reposted by Hannah LongExcited to share our hot-off-the-press @biorxivpreprint.bsky.social that explores how PRC1-mediated H2AK119ub deposition safeguards lineage fidelity during forebrain development. Fantastic work by @lucyadoyle.bsky.social and our colleagues & collaborators. 🥳🧬🧠🔬 www.biorxiv.org/content/10.1...
- Reposted by Hannah LongTranscription and Chromatin UK is back! This time in Manchester, 17th-19th September. Send your abstract by 17th July for the opportunity to discuss your work with the UK RNA and epigenetics community, and with leading experts from abroad. Click the link below and spread the word!
- Taking place on 17-19 September 2025, Transcription and Chromatin UK will showcase cutting-edge research and is a ‘mustattend’ for anyone within the transcription and epigenetics community🧪. Register now: www.eventsforce.net/biochemsoc/2...
- Reposted by Hannah LongPaper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social
- Reposted by Hannah LongPostdoc🚨! Come join our HFSP team to uncover how chromatin moves in cells and what this means for genome function! Great opportunity to combine single-cell genomics, live imaging and polymer physics in the unique mammalian retina with @andersshansen.bsky.social, Davide Michieletto & Sandra Tenreiro
- The #EMBOenhanceropathies workshop was truly outstanding - such a wonderful community to be part of and exciting science from start to finish! Group photo in front of Hindsgavl Slot @edinburgh-uni.bsky.social @uoe-igc.bsky.social - we had a blast! 🧬
- And many congratulations to @eliasfriman.bsky.social and @hannahjuellig.bsky.social for their poster prizes!
- We caught up at the poster session this afternoon. Really exciting work! 🤩
- Sad to not be there this time, but say hi 👋 to the awesome @nicola-carruthers.bsky.social who's presenting her work! #enhancers #chromatin #EMBOenhanceropathies 🇩🇰
- 🧬🎤 Very excited for the start of the EMBO Workshop in Enhancer Mechanics and Enhanceropathies this afternoon in Middelfart! Many thanks to the organizers @smandrup.bsky.social @radaiglesiaslab.bsky.social and Minna Kaikkonen for putting together an amazing programme! #EMBOenhanceropathies
- Reposted by Hannah LongI will be speaking at Fragile Nucleosome next week, join if you want to hear about the impact of endogenous retroviruses on human preimplantation development!
- Join us next Wed, for three amazing ECR researchers_ @fueyoraquel.bsky.social, @kaiamattioli.bsky.social and Laura talk about their work in #FragileNucleosome seminar series! In case you haven't joined any of the previous 2025 sessions, here is registration link: us06web.zoom.us/webinar/regi...
- 🎙️ Starting tomorrow - the 3rd International Symposium on Facial Genetics! I’m excited to hear the latest in the genetics of facial variation and functional interpretation of identified variants. What a fantastic line up of talks, posters, and lectures from Joanna Wysocka & @steinaerts.bsky.social !
- Reposted by Hannah LongReally looking forward to @radaiglesiaslab.bsky.social's talk on "Gaining mechanistic insights into long-range gene regulation through synthetic biology approaches" in @enhancedgenomics.bsky.social's seminar series. 📅 June 5th 2025 tomorrow ⏰ 4pm GMT Please join us: us02web.zoom.us/webinar/regi...
- Reposted by Hannah LongOver 140 people attended the recent Hidden Cell, Dark Genome meeting organised by @hannahlong.bsky.social, Shipra Bhatia and @drphcb-uoe.bsky.social, and a lot of interest in a follow-up meeting to hear the next updates and discoveries. You can catch up on what was discussed here: edin.ac/3HtXpwA
- Reposted by Hannah LongHHMI Investigator Joanna Wysocka studies how, during early human development, our cells read and respond to DNA instructions to turn our genes on and off at the right times. 🧵
- I had a wonderful time visiting the FMI @fmiscience.bsky.social yesterday - many thanks to @phlya.bsky.social for the kind invitation! It was great to connect with @lucagiorgetti.bsky.social, many lab members, and others across the institute. Life and science both look really fantastic in Basel!
- Reposted by Hannah LongAlways a pleasure to return to Edinburgh and visit @uoe-igc.bsky.social, I had a fantastic day discussing science and meeting old and new friends. Many thanks to @hannahlong.bsky.social for the warm hospitality-even the sky was blue!
- Such a pleasure to host you for the @uoe-igc.bsky.social seminar series @tsakiridis.bsky.social. It was great to hear about your latest exciting and impactful science and it was great to catch up! Thank you for visiting us and bringing the beautiful weather!
- Always a pleasure to return to Edinburgh and visit @uoe-igc.bsky.social, I had a fantastic day discussing science and meeting old and new friends. Many thanks to @hannahlong.bsky.social for the warm hospitality-even the sky was blue!
- Reposted by Hannah LongA tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo www.nature.com/articles/s41...
