Ilya Flyamer
Postdoc in Luca Giorgetti lab, FMI
Chromatin, Hi-C, gene regulation
Co-organizer of Sci.STEPS mentoring program
- Reposted by Ilya FlyamerTerrific paper on a new chromosomal compartment where extensive loop extrusion isolates domains from other such domains
- How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms? Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment link.springer.com/article/10.1...
- Reposted by Ilya FlyamerHave you wondered how the rules of chromatin folding have evolved? Well, this task is not easy to formalize. But here is our take on it: train species-specific DNA-to-chromatin encoder, apply to DNA of unseen species, and build chromatin rules-based tree of life. Have a look: doi.org/10.1093/nar/...
- Reposted by Ilya FlyamerWould anyone out there be able to share some Mus Spretus DNA with us? 🐀🧬 Any tissue of origin, for PCR amplification of selected genomic regions. Many thanks in advance!
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- Reposted by Ilya Flyamer📢 Last days to apply for our #PhD and #MDPhD programs! Become part of Basel, Europe’s #LifeScience hub, and grow in a dynamic, international, and supportive community. Apply by Nov 15: www.fmi.ch/education-ca...
- Reposted by Ilya Flyamer📣 Paper alert! I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today! journals.biologists.com/dev/article/...
- Last chance to become a mentor in Sci.STEP, the call is about to close!
- We are looking for mentors for the Sci.STEPS program! Please apply if you want to help your junior colleagues around the globe navigate their career path in any science related field.
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- Reposted by Ilya FlyamerReally excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication. www.biorxiv.org/content/10.1... A🧵👇
- Reposted by Ilya FlyamerNew preprint with @gfudenberg.bsky.social We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding. This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇 www.biorxiv.org/content/10.1...
- Reposted by Ilya FlyamerWe're excited to share our new preprint, "Joint decomposition of Hi-C maps reveals salient features of genome architecture across tissues and development", led by Thomas Reimonn. www.biorxiv.org/content/10.1...
- Reposted by Ilya FlyamerVery excited to share the first preprint of the lab! We show that the nuclear pore protein TPR forms biomolecular condensates which keep heterochromatin away from the nuclear pore complexes and maintains global chromatin organization. Check it out, share it, tell us what you think!!
- Biomolecular condensates at the nuclear pore basket maintain global chromatin organization biorxiv.org/content/10.1101/202…
- Reposted by Ilya FlyamerWe found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab. www.biorxiv.org/content/10.1... 1/
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- Reposted by Ilya FlyamerExcited to share our hot-off-the-press @biorxivpreprint.bsky.social that explores how PRC1-mediated H2AK119ub deposition safeguards lineage fidelity during forebrain development. Fantastic work by @lucyadoyle.bsky.social and our colleagues & collaborators. 🥳🧬🧠🔬 www.biorxiv.org/content/10.1...
- Reposted by Ilya FlyamerCalling all aspiring Postdocs! One extra week to apply to join our exciting HFSP-funded project to uncover how chromatin moves to function. Deadline July 15th. www.mdc-berlin.de/career/jobs/...
- Postdoc🚨! Come join our HFSP team to uncover how chromatin moves in cells and what this means for genome function! Great opportunity to combine single-cell genomics, live imaging and polymer physics in the unique mammalian retina with @andersshansen.bsky.social, Davide Michieletto & Sandra Tenreiro
- Reposted by Ilya FlyamerI'm proud to announce the latest release of 🧬 #Oxbow 🏹, with new features to make NGS data analysis more powerful, efficient, and "composable". Learn more at: oxbow.readthedocs.io
- Reposted by Ilya FlyamerWe are looking for a research assistant to join our lab and support ongoing projects with genome engineering in mouse embryonic stem cells! Please get in touch if you are interested. www.fmi.ch/education-ca...
- Reposted by Ilya FlyamerPostdoc🚨! Come join our HFSP team to uncover how chromatin moves in cells and what this means for genome function! Great opportunity to combine single-cell genomics, live imaging and polymer physics in the unique mammalian retina with @andersshansen.bsky.social, Davide Michieletto & Sandra Tenreiro
- Reposted by Ilya FlyamerWe're hiring a postdoc! Come join my lab @Novartis Oncology in Basel 🇨🇭, and employ genome engineering and functional genomics approaches to study how oncogenic Transcription Factors function at the molecular level (and how to drug them) 3+1 years! Apply! Please RP www.novartis.com/careers/care...
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- Reposted by Ilya FlyamerWant to work with us on DNA methylation and rare genetic disease? Fully funded PhD project with deadline 16th May: www.findaphd.com/phds/project... Excited to collaborate with @hannahlong.bsky.social and Daria Bunina (@uoe-igc.bsky.social/@mdc-berlin.bsky.social). Please share 🙏 #epigenetics
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- Reposted by Ilya FlyamerCelebrating 10 years of our lab with a new preprint: www.biorxiv.org/content/10.1... How does enhancer location within a TAD control transcriptional bursts from a cognate promoter? Experiments by Jana Tünnermann and modelling by Gregory Roth
- Reposted by Ilya Flyamer📣 We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬🧪
- What happens if an expression construct has strong predicted splice donor sites inside the ORF? Would removing them increase protein expression?
- Reposted by Ilya FlyamerThree-dimensional organization of amoeba Dictyostelium discoideum has fascinating features! Very prominent dots at between convergent gene positions, something never really seen for other species. More about the puzzle and how the team of my PhD colleagues resolves it: doi.org/10.1093/nar/...
- Reposted by Ilya FlyamerExcited to share James Jusuf's preprint: By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%) We quantify mESC 36k loops: <loops> are generally rare (2.3%) www.biorxiv.org/content/10.1...
- Help us decide! Where would it be easier for you to come and chat to us about using or contributing to Open2C software?
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- Reposted by Ilya FlyamerCouldn't agree more with Paul Nurse that “Research institutes and units play a unique, beneficial role in the UK’s RDI landscape and this sector should be expanded....” So the MRC should rethink their regressive decision to close MRC Units. www.science.org/content/arti...
- Last chance to apply for the 2025 edition of the Sci.STEPS program! Don't miss your opportunity to get career advice and guidance from one of our experienced mentors.
- 🔊 Only a few days left to apply as a MENTEE for the 3rd Mentorship Season! 🌟 Submit your application by DECEMBER 15th! 🌟 Apply to gain access to helpful resources, personalized skill development, and networking opportunities that can support your scientific career path. www.scisteps.org/call-2025
- The deadline to apply to the Sci.STEPS program is approaching! Apply asap if you need help navigating your career in science.
- 🔊 Only a few days left to apply as a MENTEE for the 3rd Mentorship Season! 🌟 Submit your application by DECEMBER 15th! 🌟 Apply to gain access to helpful resources, personalized skill development, and networking opportunities that can support your scientific career path. www.scisteps.org/call-2025
- Reposted by Ilya FlyamerWe've been awarded a UKRI MRC grant to examine the causes and consequences of #heterochromatin hypomethylation in cancer 🥳. #postdoc opportunity coming in the near future. #epigenetics. Please share with anyone who might be interested.
- Reposted by Ilya FlyamerNavigating your PhD? Sci.STEPS connects you with experienced peers who've navigated these waters before. From career paths to research challenges, having someone to talk to makes the difference. Join Sci.STEPS and set your course! Apply now 🧭✨
- 📢We have opened the call for #mentees! Apply and become a mentee: scisteps.org/call-2025 Sci.STEPS mentors share with you their knowledge and insights on studying abroad, navigating relocations, building careers, and transitioning between fields!💙 @phdvoice.bsky.social @dragonflymh.bsky.social
- After a month of hard work to create a pool of over 50 fantastic mentors, we have opened the call for mentee applications! If you are an early career researcher and need help navigating the career path (be it academia or industry, or anything else), see if there is a mentor for you and apply!
- 📢We have opened the call for #mentees! Apply and become a mentee: scisteps.org/call-2025 Sci.STEPS mentors share with you their knowledge and insights on studying abroad, navigating relocations, building careers, and transitioning between fields!💙 @phdvoice.bsky.social @dragonflymh.bsky.social
- Please share! ☝️
- Last day to apply as a mentor to the Sci.STEPS program! @academic-chatter.bsky.social #mentoring #science
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