Nezha Benabdallah
Group leader at the University of Edinburgh.
Chromatin, Gene Regulation & Sarcoma
benabdallah-lab.com
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- Reposted by Nezha BenabdallahThis is for you – and a great opportunity – if you are establishing a group in Croatia, Czechia, Estonia, Hungary, Lithuania, Luxembourg, Poland, Portugal and Türkiye...
- Apply now! The 2026 call for the EMBO Installation Grants Programme is now open with a deadline of 15 April 12:00 midday CEST. 🧪 More information can be found here: embo.org/funding/fellowships… #LifeSciences #research #funding
- Reposted by Nezha Benabdallahwww.nature.com/articles/s41... happy i could be a part of this paper from the Gilan lab out now. Along with many other things, it provides strong evidence of chromatin memory for gene activation, and suggests that DOT1L is the missing link balancing the fast and slow arms of the MLL/Polycomb axis
- Reposted by Nezha Benabdallah🧪 My lab has an opening for a postdoc position soon! Please share/get in touch!
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- Reposted by Nezha BenabdallahCheck out our new findings showing BRD4's role in preventing the premature activation of developmental transcription factors via #Polycomb, providing new mechanistic insights into the pathogenesis of neurodevelopmental disorder #CdLS #NDDs, #chromatinopathies www.biorxiv.org/content/10.6...
- Reposted by Nezha BenabdallahExposure to voter suppression ads on Facebook—which targeted non-White residents of battleground states—was associated with a 1.9% decrease in voter turnout in the 2016 election, representing approximately 4.7 million fewer votes nationwide. In PNAS: ow.ly/HJGf50Y7FPG
- Reposted by Nezha Benabdallah📣 I'm excited to share our latest preprint! We adapt and characterise a neurosphere-based CNCC differentiation protocol, and demonstrate utility for quantitative phenotyping and craniofacial disease modelling! 🧫 Read about Array-CNCC here: www.biorxiv.org/content/10.6... @uoe-igc.bsky.social
- Reposted by Nezha BenabdallahSynovial sarcoma is driven almost exclusively by a single oncofusion – SS18-SSX For years, the assumptions on disease mechanisms were simple: ➡️ SS18-SSX works by hijacking SWI/SNF chromatin remodeling activity Our new study shows that assumption was wrong 🧵👇 www.biorxiv.org/content/10.6...
- SS18::SSX activates Polycomb target genes without BAF ❌ Instead, transcription relies on EP300 via the SS18 QPGY domain www.biorxiv.org/content/10.6... ➡️ Coactivator targeting emerges as a new therapeutic strategy in synovial sarcoma 🎯 Team work from @banitolab.bsky.social and @uoe-igc.bsky.social
- I did not know she was on Bluesky, but this whole work was led by @afroditisotiriou.bsky.social, a truly talented scientist that will finish her PhD this year and has not started looking for postdoc positions yet...
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- Very cool! Can't wait to see single-cell TimeVault 🤩
- 🧬🔬@science.org A genetically encoded device for #transcriptome storage in mammalian cells | Science www.science.org/doi/10.1126/... @broadinstitute.org
- Reposted by Nezha Benabdallah🧬🔬@science.org A genetically encoded device for #transcriptome storage in mammalian cells | Science www.science.org/doi/10.1126/... @broadinstitute.org
- Reposted by Nezha BenabdallahWe are looking for a postdoc to join our team! If you're interested in translating a cutting edge genomics technology (www.nature.com/articles/s41...) to real-life applications in hematology, this is for you. We offer a unique working environment ON THE BEACH: recruitment.crg.eu/content/jobs...
- We have an exciting PhD opportunity through the EASTBIO programme, co-supervised with Diego Oyarzún. This project combines synthetic and systems biology to uncover the gene-regulatory circuitry hijacked in a cancer model. We’re looking for candidates with a strong interest in functional genomics.
- Reposted by Nezha BenabdallahI'm a longtime fan of Affinity Designer as an affordable Illustrator-killer for figures, and... it's now free?! www.canva.com/newsroom/new... Highly recommended if you're sick of paying Adobe $. Maybe Canva can buy NPG too and get rid of the OA fees.
- Reposted by Nezha Benabdallah📣Job Opportunity: Develop machine learning of cellular automata models with applications to in vitro developmental biology. More info: edin.ac/49Mr7ZQ
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- Beautiful (jaw-dropping 😉) work from Hannah Long’s group revealing how Neandertal enhancers influence facial morphology!
- 📣 Paper alert! I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today! journals.biologists.com/dev/article/...
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- Reposted by Nezha Benabdallah🥁This Wednesday , in #FragileNucleosome seminar, we are excited to host @hannahlong.bsky.social and @jeffvierstra.bsky.social to tell us about amazing work they are doing! 🗓️Register here for upcoming session and the entire series: us06web.zoom.us/webinar/regi...
- Reposted by Nezha BenabdallahEver wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one? Check our latest preprint, led by @mmasoura.bsky.social, to find out! www.biorxiv.org/content/10.1...
- Reposted by Nezha BenabdallahWhat is a promoter? And how does it work? We very happy to share our latest work trying to understand enhancer-promoter compatibility. I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters www.biorxiv.org/content/10.1...
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- Reposted by Nezha BenabdallahIf you’re interested in exploring the relationship between chromatin organization and epigenetic memory using chromatin tracing microscopy, my group is recruiting a talented PhD student 🥳
- 🚨 Please share! We are seeking motivated PhD students who wish to work at the intersection of molecular life sciences and computational sciences. #IMPRS #IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de Check out our projects and apply by Jan 7th, 2026! www.molgen.mpg.de/IMPRSPhDproj...
- Reposted by Nezha Benabdallah🧵1/ Excited to share our new paper introducing a new #singlecell assay: scTF-seq, a high-throughput single-cell approach to explore how transcription factor (TF) dose shapes cell identity and reprogramming outcomes. 🔗 www.nature.com/articles/s41... Big congrats to the entire team @EPFL & @SIAT_China
- Reposted by Nezha BenabdallahAnd look at this graphic abstract….. 😱🤯
- Homie got 229 pairs of chromosomes www.sciencedaily.com/releases/202...
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- Fascinating!
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- Reposted by Nezha BenabdallahHot off the press! Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4 www.nature.com/articles/s41...
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- Reposted by Nezha BenabdallahWe have space for two postdoctoral fellows in the Taipale Lab at the @sangerinstitute.bsky.social. This is a core-funded open position! Come with your ideas and interests and we can develop a project together. sanger.wd103.myworkdayjobs.com/en-US/Wellco...
- Reposted by Nezha BenabdallahGreat opportunity! Up to 4 Group Leader positions at the NOVA Institute for Medical Systems Biology (NIMSB) in Computational & Experimental Medical Systems Biology 📍 Lisbon ⏳ Apply by Oct 8 🔗 nimsb.unl.pt/wp-content/u... #Job #SciencePositions #JobOffer #GroupLeaders #Innovation #systemsbiology
- Reposted by Nezha BenabdallahJoin @cmaley.bsky.social, @lucielaplane.bsky.social, Joel Brown and Benjamin Spada for a live EvoChat discussion about "How we define cancer matters", hosted by the International Society for Evolution, Ecology and Cancer (ISEEC). Oct 1st at 8am PST, 11am EST, 5pm CEST ucsb.zoom.us/j/8313111375...
- Reposted by Nezha BenabdallahThis is a disaster if the EU doesn't follow up by doubling the budget 😬🧪
- record 17,058 Marie Curie proposals in 2025 vs. 10,360 in 2024!!! the reason is pretty obvious, but wow that is a huge jump marie-sklodowska-curie-actions.ec.europa.eu/news/msca-po...
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- Reposted by Nezha BenabdallahThis is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇
- Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...
- Reposted by Nezha BenabdallahDomain analysis identifies a discrete nucleic acid-binding domain (NBD) within SUZ12 responsible for constraining PRC2 activity. CryoEM studies showed the NBD in close proximity to nucleic acids. Loss of this region (NEC, VEFS) causes global H3K27me3 hypermethylation. 11/13
- simply wonderful science 🤩
- 🦠🧍♀️From bacterial to human immunity. We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity. Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social www.science.org/doi/10.1126/...
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- Reposted by Nezha Benabdallah📢 We are recruiting! Several projects are available and can be tailored to the candidate's profile. Most include confocal imaging/spatial OMICs technologies. Please share and RT 🙏
- Reposted by Nezha BenabdallahAnother paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
- Reposted by Nezha BenabdallahVery excited to share the first preprint of the lab! We show that the nuclear pore protein TPR forms biomolecular condensates which keep heterochromatin away from the nuclear pore complexes and maintains global chromatin organization. Check it out, share it, tell us what you think!!
- Reposted by Nezha BenabdallahOnce a surfer's paradise, a string of deadly attacks made Réunion Island synonymous with one word only: sharks. But a team of scientists turned this tiny island into a hub of lifesaving research. For @science.org, I wrote about this fascinating place. www.science.org/content/arti...
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- Reposted by Nezha BenabdallahExcited to share our hot-off-the-press @biorxivpreprint.bsky.social that explores how PRC1-mediated H2AK119ub deposition safeguards lineage fidelity during forebrain development. Fantastic work by @lucyadoyle.bsky.social and our colleagues & collaborators. 🥳🧬🧠🔬 www.biorxiv.org/content/10.1...
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- Reposted by Nezha BenabdallahExcited to share the lab's 1rst preprint! Rapid high-res immunofluorescence is now possible in cultured & environmental diatoms thanks to 4-fold expansion microscopy. A step-change for comparative cell biology in one of the most important phytoplankton groups on the planet 🥳 tinyurl.com/m9s5su7s 1/2
- Reposted by Nezha BenabdallahEPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!
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