Daniel Lipka
Physician Scientist at DKFZ & NCT Heidelberg
studying 🩸🧬 #epigenomics #DNAmethylation #singleCell #precisiononcology #JMML
www.translational-cancer-epigenomics.de
- Reposted by Daniel LipkaSame mutation ≠ same leukemia. Wagenblast et al. show: • fetal HSCs readily transform • postnatal HSCs become resistant • fetal programs create targetable vulnerabilities Ontogeny matters: state-of-origin shapes biology & therapy response. doi.org/10.1158/2159... #pediatric #AML #stemcells
- Reposted by Daniel LipkaJMML stem cells aren’t epigenetically “stuck” in a fetal state. They mature postnatally—yet show striking transcriptional plasticity, with oncofetal reprogramming in high-risk disease, challenging the classic “maturation block” model. doi.org/10.1158/2643... #JMML #epigenetics #hematology #cancer
- Reposted by Daniel LipkaNew Spotlight in @aacrjournals.bsky.social #Oncogene × #Ontogeny × #Plasticity shape leukemia biology & therapy response. Two complementary studies show: mutations alone don’t explain disease behavior—developmental state and cellular plasticity matter. aacrjournals.org/bloodcancerd... 🩸🧬 EpiSci
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- Reposted by Daniel LipkaOur preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)
- Reposted by Daniel LipkaExcited to share new manuscript on histone acylations, exploring how H4K16 acylations regulate inter and intranucleosomal interactions and how they confer resilience to metabolic challenges in vivo. Thanks to all authors +1 author @sandrani.bsky.social Enjoy 👇👇 www.sciencedirect.com/science/arti...
- Reposted by Daniel LipkaNeue Erkenntnisse zu frühkindlicher Leukämie: Leukämiezellen können Programme aus der fetalen Entwicklung erneut aktivieren. Die Ergebnisse eröffnen neue Angriffspunkte für Diagnostik und Therapie. www.nct-heidelberg.de/das-nct/news... @dkfz.bsky.social @mphartmann.bsky.social @dblipka.bsky.social
- 👉🏼 @milsommick.bsky.social talking about the role of inflammation on HSC aging in the “Game of Clones” Scientific Session at #ASH25. #epigenomics #hematopoiesis #HemeSky @dkfz.bsky.social
- Interested in DNA methylation and want to hear what we can learn from it regarding lineage commitment decisions in #hematopoiesis? #ASH25 #epigenomics #HemeSky
- Very happy and proud to see this story finally published! 🎉🥳 #epigenetics #hematology #jmml #leukemia
- ONLINE FIRST ALERT! Molecular #Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia aacrjournals.org/bloodcancerd... @aacrjournals.bsky.social #childhoodcancer #epigenetics #precisiononcology
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- Great to meet friends and colleagues at this year’s EWOG-MDS meeting in Berlin. We had great discussions and developed new project ideas and collaborations with the aim of improving risk stratification and patient care for JMML patients. #jmml #ewogmds #precisionmedicine www.ewogberlin2025.org
- Reposted by Daniel LipkaOn behalf of @ckadoch.bsky.social and myself, we are pleased to present our upcoming @KeystoneSymposia, #KSEpigenetics26 Epigenetics and Gene Regulation in Health and Disease, March 2-5, in Geneva, Switzerland. keysym.us/KSEpigenetic...
- Of interest to the #epigenomics, #dnamethylation, #neurooncology, #oncology and #precisionmedicine communities! 🧬
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- Reposted by Daniel LipkaActivity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...
- Still two weeks left to apply to the #postdoc position in my lab via the @dkfz.bsky.social fellowship program. #epigenomics #hematology #leukemia #computationalbiology #precisiononcology
- +++ Postdoc Opportunity +++ My lab is looking for researchers interested in combining cutting edge #genomics, #epigenetics and #AI for precision oncology in pediatric #leukemia. www.dkfz.de/fileadmin/us... Applications via the #DKFZ postdoc program: www.dkfz.de/en/karriere/...
- Reposted by Daniel LipkaEvery so often, a paper lands at exactly the right moment. This one’s a gem. Can’t wait to try out this new strategy for delivering CRISPRoff chromatin-editing tools into our favorite cellular model system. Congrats to James K Nuñez and his team: www.nature.com/articles/s41...
- Reposted by Daniel LipkaExcited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....
- +++ Postdoc Opportunity +++ My lab is looking for researchers interested in combining cutting edge #genomics, #epigenetics and #AI for precision oncology in pediatric #leukemia. www.dkfz.de/fileadmin/us... Applications via the #DKFZ postdoc program: www.dkfz.de/en/karriere/...
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- Reposted by Daniel LipkaI am delighted to share a publication in @natcomms.nature.com. IRX3, linked to obesity via the FTO locus, influences fat vs bone cell fate. It is the result of a wonderful collaboration between S. Dankel, G. Mellgren @unibergen.bsky.social and my lab @biovitenskap.bsky.social 🍾 👉 rdcu.be/ezA5o
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- Reposted by Daniel LipkaHappy to share our recent publication on benchmarking peak calling methods for CUT&RUN. academic.oup.com/bioinformati... Published in @oxunipress.bsky.social Bioinformatics | led by aminnoorani.bsky.social #Epigenomics #Genomics #Bioinformatics #MachineLearning #CUTandRUN #CompBio #4DNucleome
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- Reposted by Daniel LipkaFlybase lost all of the NIH support overnight - it is a disaster for the community. Please consider donating. I just did! www.philanthropy.cam.ac.uk/give-to-camb...
- Reposted by Daniel LipkaHow does metabolism act through generic chromatin modifiers promote specific cellular states? Simultaneous modification of transcription factors and chromatin, enhancing epigenetic signal to noise ratios. www.embopress.org/doi/full/10....
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- Few days left to apply for a #postdoctoral position in my team investigating the pathomechanism of IDH1 mutations at the interface of #metabolism and #epigenomics!
- Hey #HemeSky and #EpiSci folks! We are hiring! For our Translational Cancer Epigenomics team @dkfz.bsky.social and @nct-heidelberg.bsky.social we are looking for a talented postdoc interested in research on heme malignancies and #epigenetics. Interested? 👉See jobs.dkfz.de/en/jobs/1676... or DM me!
- Reposted by Daniel LipkaWe are recruiting! Senior postdoc in computational cancer genomics/epigenomics @ludwigcancer.bsky.social @ox.ac.uk. Lead research into epigenetic drivers of secondary AML with rich omics data + strong clinical/wet-lab collaborations. cutt.cx/YUoB We look forward hearing from you! #epigenetics #jobs
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- Reposted by Daniel LipkaNew paper from my lab! Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis: rdcu.be/eh1Nb Complementary to new work from Steven Chan & @georgevassiliou.bsky.social as described by @goodell-lab.bsky.social: www.nature.com/articles/d41...
- Reposted by Daniel LipkaJust over 24 hours to get your abstract submitted
- Abstract submission for the EHA Mol Hem workshop closes on Fri 11th at 5pm CEST. Don't miss your chance to showcase your research in this well attended interactive setting at the #EHA2025 annual meeting in Milan ehaweb.org/congress/eha...
- Congratulations to everyone!
- The results are in 🗳️ Congratulations to our incoming 2025-2026 Board of Directors who will start their terms at the conclusion of #ISEH2025🏯 in September! 👏
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- Hey #HemeSky and #EpiSci folks! We are hiring! For our Translational Cancer Epigenomics team @dkfz.bsky.social and @nct-heidelberg.bsky.social we are looking for a talented postdoc interested in research on heme malignancies and #epigenetics. Interested? 👉See jobs.dkfz.de/en/jobs/1676... or DM me!
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- Very interesting workshop highlighting recent developments in molecular #hematopoiesis #HemeSky
- Abstract submission for the Molecular Hematopoiesis Workshop at the EHA annual meeting in Milan is now open! Selected speakers get annual meeting registration; hotel accommodation; & travel reimbursement. More details and abstract submission here: ehaweb.org/congress/eha...
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- Epigenetic memory of chronic inflammation in intestinal stem cells primes for malignant transformation. #EpiSci
- New to bluesky, but I’m excited to share my work over the last few years with @jbuenrostro.bsky.social! Chronic inflammation creates an epigenetic memory in colonic stem cells, priming them for tumor growth: tinyurl.com/ColitisNagar.... Here’s a walkthrough of what we found (🧵)
- Reposted by Daniel LipkaNew to bluesky, but I’m excited to share my work over the last few years with @jbuenrostro.bsky.social! Chronic inflammation creates an epigenetic memory in colonic stem cells, priming them for tumor growth: tinyurl.com/ColitisNagar.... Here’s a walkthrough of what we found (🧵)
- Great tool to dissect methylome data from bulk tumor samples at single-molecule resolution! #EpiSci
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- Cool work! 😎 Congratulations! 🎉
- #CellPlasticity—the ability of cells to change their identity—is vital for tissue growth and repair. But when it goes unchecked, it can fuel #cancer. Our latest study examines how to block #LiverCancer by actively suppressing plasticity. www.nature.com/articles/s41... #CancerBiology
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- 👉🏻Great opportunity in an excellent lab!
- Reposted by Daniel LipkaWir suchen 2 Oberärzt:Innen (Akute Leukämien und Allo-TX). Wir bieten das gesamte Spektrum der univ. Hämatologie von mol. Diagnostik bis ICU mit einem fantastischen Team. karriere.ume.de/job-finder/?... karriere.ume.de/job-finder/?... Bei Interesse melden Sie sich bitte sehr gerne bei uns!
- Reposted by Daniel LipkaNew pre-print from Thomas Höfer, Daniel Hübschmann, @haas_lab and myself, with first authors @Esther_RCorrea @FloGrunschlager and Tamar Nizharadze doi.org/10.1101/2025... @DKFZ @NCT_HD @ChariteBerlin @hi_stem_lab BIH & MDC
- Reposted by Daniel LipkaEver wondered what drives hematopoietic stem cell (HSC) heterogeneity? In this preprint, our collaborative team uncovered that differences in HSC reconstitution kinetics play a key role in shaping stem cell heterogeneity and lineage biases. doi.org/10.1101/2025... (1/2)
- Interesting work from the Tomkova group relating DNA hypermethylation of polycomb-repressed regions with gene upregulation. #Epigenetics #DNA_Methylation
- Reposted by Daniel LipkaIn the Jan issue of @isehsociety.bsky.social journal, the very first “Society Voices article: Advice for effective leadership and hitting the ground running as a new group leader - Experimental Hematology www.exphem.org/article/S030...
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- Reposted by Daniel LipkaThrilled to share a wonderful collaboration with Scott Armstrong, Florian Perner & Shellaina Gordon - exciting times ahead! www.biorxiv.org/content/10.1...
