Thomas Walle
trying to help patients by understanding their individual immune status
scholar.google.com/citations?user…
- Reposted by Thomas Walle[Not loaded yet]
- Reposted by Thomas Walle[Not loaded yet]
- 🧵Radiotherapy immune signaling is modular, redundant — and has a limit. Together with @joschakraske @peterhuber_hd @halama_immuno @UKHD_radonc our new study in fully human systems shows that: t.co/GzH3N6gElf 1/9
- - Radiation triggers coordinated chemokine modules (SASP) - Multiple chemokines in each module target the same immune cells - Chemokine release is maxed out at clinically relevant dose ranges - A new explant model allows studying radiation-induced SASP in patient PDAC tissue. 2/9
- 1/ Modular SASP After irradiation, tumor cells release chemokines in defined “modules.” Each module communicates with several receptors expressed on the same immune cell types. 3/9
-
View full threadRadiotherapy-immune crosstalk is robust but limited Immune modulation will require targeting sets of chemokines Dose escalation alone can’t push beyond the biological ceiling Understanding these concepts is key to better radio-immunotherapies 9/9
- Reposted by Thomas Walle🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktarlab.bsky.social @oliverstegle.bsky.social and @moritzmall.bsky.social, Preprint at end🧵👇
