Mark Hartmann
Scientist at DKFZ and NCT Heidelberg
#epigenetics #stemcells #leukemia #colorectalcancer #multiomics #precisiononcology
#oncofetal #reprogramming
#plasticity
www.translational-cancer-epigenomics.de
- New Spotlight in @aacrjournals.bsky.social #Oncogene × #Ontogeny × #Plasticity shape leukemia biology & therapy response. Two complementary studies show: mutations alone don’t explain disease behavior—developmental state and cellular plasticity matter. aacrjournals.org/bloodcancerd... 🩸🧬 EpiSci
- Same mutation ≠ same leukemia. Wagenblast et al. show: • fetal HSCs readily transform • postnatal HSCs become resistant • fetal programs create targetable vulnerabilities Ontogeny matters: state-of-origin shapes biology & therapy response. doi.org/10.1158/2159... #pediatric #AML #stemcells
- JMML stem cells aren’t epigenetically “stuck” in a fetal state. They mature postnatally—yet show striking transcriptional plasticity, with oncofetal reprogramming in high-risk disease, challenging the classic “maturation block” model. doi.org/10.1158/2643... #JMML #epigenetics #hematology #cancer