Mark Hartmann
Scientist at DKFZ and NCT Heidelberg
#epigenetics #stemcells #leukemia #colorectalcancer #multiomics #precisiononcology
#oncofetal #reprogramming
#plasticity
www.translational-cancer-epigenomics.de
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- CellRank protocol now in @NatureProtocols! 🎉 @PhilippWeiler's detailed guide shows how to: - Integrate velocity, pseudotime & time points - Infer cell fate probabilities - Analyze lineage priming at scale Great complement to our CellRank 2 paper! 📖 www.nature.com/articles/s41...
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- When you agree to serve in a committee
- Beyond pleased to announce our lab has secured its first @cancerresearchuk.org funding with an Early Detection & Diagnosis Project Award titled: 'Detecting and targeting translation inhibitor sensitive RUNX1 mutations in Chronic Myeloid Leukaemia' 1/5 www.cancerresearchuk.org/for-research...
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View full threadYou keep us on tenterhooks, what are those exciting discoveries??? 😲 Looking forward to find out more, hopefully some time soon. 😉
- 😜 coming soon....
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- This paper marks the end of a long but rewarding project - and the start of something new (more below👇). Massive thanks to @kaessmannlab.bsky.social, @ioansarr.bsky.social, @tyamadat.bsky.social, our amazing collaborators @steinaerts.bsky.social, Stefan Pfister, Rüdiger Behr and the entire team! 💙
- We are thrilled that our study on the evolution of gene regulation in mammalian cerebellum development – led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social – is now out in @ScienceMagazine! www.science.org/doi/10.1126/...
- I've started my own lab 🎉 PhD/postdoc positions available - reach out if curious about cerebellum evo-devo and autism spectrum disorders. We’re based at Uni Tartu, Institute of Genomics (home to Estonian Biobank), and funded by @simonsfoundation.org @embo.org, and the Estonian Research Council.
- We are thrilled that our study on the evolution of gene regulation in mammalian cerebellum development – led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social – is now out in @ScienceMagazine! www.science.org/doi/10.1126/...
- How does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development! rb.gy/dbcxjz Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social
- 🗣️Bridging developmental biology and childhood cancer research: The St. Anna CCRI Symposium 2026 brought together researchers to discuss cell fate in cancer and development and spark new collaborations. 🔬Together, we advance pediatric cancer research. www.youtube.com/watch?v=szcT...
- Was wonderful to participate in this symposium. Thanks for the invitation.
- 🗣️Bridging developmental biology and childhood cancer research: The St. Anna CCRI Symposium 2026 brought together researchers to discuss cell fate in cancer and development and spark new collaborations. 🔬Together, we advance pediatric cancer research. www.youtube.com/watch?v=szcT...
- Very pleased to share our latest pre-print which showcases the incredible hard work and skill of Dr Okan Sevim. Our continued exploration of β-catenin's contribution to the post transcriptional landscape of blood cells led us to a LIN28B interaction. 1/7 www.biorxiv.org/content/10.6...
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View full threadAbsolutely, we see pronounced fetal signatures in JMML, too: aacrjournals.org/bloodcancerd... Unfortunately, LIN28B is not well captured in the scRNA data. However, I remember clusters revealing pronounced b-catenin expression patterns. Will check this again… maybe we can find shared programs.
- Very cool paper, on my reading list! We were desperate to get hold of some primary JMML samples for this very reason but not a resource widely available in the UK. We'd be very interested in hearing more about this. Perhaps we could talk more offline?
- Exciting topic! Looking forward to reading this preprint.
- Thanks Mark, we think so too although of course a little biased. Hopefully the field agrees! LIN28B is a fascinating RBP in the haematopoietic system.
- Well done Okan!
- Very pleased to share our latest pre-print which showcases the incredible hard work and skill of Dr Okan Sevim. Our continued exploration of β-catenin's contribution to the post transcriptional landscape of blood cells led us to a LIN28B interaction. 1/7 www.biorxiv.org/content/10.6...
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- 🚀 Excited to share new paper in Nature Genetics: Human Retina Cell Atlas (HRCA) with ~4M cells, >130 retinal cell types, deep scRNA/ATAC integration. Enables cross-species comparisons & GWAS cell-type enrichment. Huge thanks to Ignacio Ibarra & Chen lab. www.nature.com/articles/s41...
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- Tha'ts what scientists want too. We need AI that makes sure you don't break the dishes (or centrifuge)
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- 🚨We have an opening for Data Scientists or Bioinformaticians using machine learning and AI with all kinds of molecular data to support cancer research. 🧬 Permanent position, fantastic team, exciting projects—what more could you ask for? www.lih.lu/en/job/?valu...
- Very early days, but delighted that our recent review on reevaluation of aging hematopoiesis published in Experimental Hematology, official journal of @isehsociety.bsky.social is classified as highly cited by web of science. Open access here: www.exphem.org/article/S030...
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- Out in print this week @bloodjournal.bsky.social . Very proud of this collaborative work with Prof Karadimitris @imperialimmuno.bsky.social. Thanks to @cancerresearchuk.org and CwC_UK for funding this work. #InfantALL @paediatrics.ox.ac.uk @imm.ox.ac.uk
- Off-the-shelf bispecific CD133-CD19 CAR-iNKT cells eradicate CAR antigen–high and –low medullary and leptomeningeal KMT2Ar ALL. Read in Blood: buff.ly/HIlsUq7 #ALL #BloodJournal
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- Frühkindliche Leukämie: Zellen reaktivieren fetale Programme Forschende am Nationalen Centrum für Tumorerkrankungen (NCT) Heidelberg und am Deutschen Krebsforschungszentrum (DKFZ) haben neue Erkenntnisse gewonnen, wie eine bestimmte frühkin... weiterlesen
- Scientists identify #IGF2BP1 as a driver of #ImmuneEvasion in C5 #OvarianCancer, suppressing IFN‑γ–IRF1–MHC‑I signaling and T‑cell infiltration; its inhibition restores #antitumor immunity and boosts #PD1blockade. @unihalle.bsky.social #OpenAccess in #STTT: doi.org/10.1038/s413...
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- Epigenetics that matters! Very cool work on hard to hard-to-access cell types . Finally some solid epigenetics examples that should be used in textbooks! Congrats to Mathieu and team @embl.org Rome!
- This went under the radar but answers a fundamental question in Epigenetics... From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How? Outstanding work from Mathieu Boulard and colleagues www.biorxiv.org/content/10.6...
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- Merry Christmas and a Happy New Year from our lab! May 2026 bring everything you hope for!
- 🚀 New preprint! The Human Cytokine Dictionary - 9.7M cells, 12 donors, 90 cytokines - our largest human single-cell perturbation atlas yet. Users can map cytokine activity in their own data. Huge thanks to Lukas, Sören, Larsen, Parse Bio & Seelig lab! 🔗 www.biorxiv.org/content/10.6...
- #HochschulBarometer2025 ist da. Wir sehen deutlich: An staatlichen Universitäten schreitet Fachkräftemangel weiter voran. Dank #IchBinHanna überlegen sich die Leute, ob sie prekäre Beschäftigung ohne Zukunftschancen wirklich wollen. Was hilft? Perspektiven schaffen mit guter Reform des #WissZeitVG!
- Check out the outlook article in Nature Magazin with a focus on the role of neural innervation in pancreatic cancer featuring our Nature publication www.nature.com/articles/d41...
- Neue Erkenntnisse zu frühkindlicher Leukämie: Leukämiezellen können Programme aus der fetalen Entwicklung erneut aktivieren. Die Ergebnisse eröffnen neue Angriffspunkte für Diagnostik und Therapie. www.nct-heidelberg.de/das-nct/news... @dkfz.bsky.social @mphartmann.bsky.social @dblipka.bsky.social
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