Schwalbe Lab
NMR spectroscopy on nucleic acids and proteins based at Goethe-University Frankfurt, Germany.
This account is run by the members of the Schwalbe lab.
schwalbe-lab.de
#nmr #biomolecules #rna #proteins #dna #drugtargeting #interactions
- New paper out in microLife: evaluating proteomics workflows to reduce missing values, with a focus on reliable quantification of small proteins. Practical insights for improving coverage and data quality. academic.oup.com/microlife/ar... #Proteomics #MassSpectrometry #SmallProteins #Microbiology
- Reposted by Schwalbe LabFragment-Screen coordinator Harald Schwalbe is presenting on NMR screening and the outcomes of the project at the @eu-openscreen.bsky.social Impulse Winter Training School! Find out more about the meeting and Fragment-Screen here - fragmentscreen.org/winter-train... @schwalbe-lab.bsky.social
- Reposted by Schwalbe LabGreat to see that the Instruct-ERIC review of the future of integrated structural biology is continuing to be highlighted! Find out more about the paper and read here - instruct-eric.org/news/the-fut... @schwalbe-lab.bsky.social
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- Check out the newest publication of the Wöhnert lab! ☺️ "Crystal structure of the class V GTP-binding RNA aptamer bound to its ligand: GTP recognition by a topologically complex intermolecular G-quadruplex" Full text: academic.oup.com/nar/article/... #G4 #X-ray #aptamer #NAR
- New publication alert 🎉 Our latest paper explores how small molecules can bind SARS-CoV-2 RNA, combining in silico screening with NMR experiments to uncover promising RNA-targeting candidates. full text: chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/... #RNA #NMR #screening #drugtargeting
- Reposted by Schwalbe LabLucia Banci, Instruct-IT, and Harald Schwalbe visit the new Instruct-DE research side at TU Munich. Lucia covers the technological developments in drug screening by in-cell NMR, supported by Fragment-Screen fragmentscreen.org @schwalbe-lab.bsky.social @cerm-cirmmp.bsky.social @tumunich.bsky.social
- Reposted by Schwalbe LabAt this years German User Meeting of Bruker, Instruct Director Prof. Harald Schwalbe introduced the Access options in Instruct for structural biology to more than 200 NMR Scientists, including many facility managers from Germany, Austria and Switzerland - instruct-eric.org @schwalbe-lab.bsky.social
- Our work on DNA G4 interactions with Zuo1 in collaboration with @paeschkelab.bsky.social and the Penedo lab is out in @narjournal.bsky.social 😍 Full text: academic.oup.com/nar/article/... #G4 #G-Quadruplex #NMR #smFRET #ChIP-qPCR
- Have a look into our newest publication showing how GS-441524 derivatives can potently inhibit the SARS-CoV-2 macrodomain (Nsp3b), offering a structural roadmap for next-generation antiviral design. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/... #SARSCoV2 #NMR #drugtargeting #synthesis
- Reposted by Schwalbe LabProf. Harald Schwalbe presenting Fragment-based Drug Discovery at at the 25th ChemBioChem Symposium! Prof. Schwalbe is coordinator of the Fragment-Screen project, developing new tools for fragment-based drug discovery Find out more here - fragmentscreen.org/home @schwalbe-lab.bsky.social
- Great news: Harald Schwalbe has been reappointed as Director of Instruct-ERIC, extending his term through Dec 2031. His leadership shows strong confidence in his work advancing structural biology and research collaboration across Europe. @instruct-eric.bsky.social instruct-eric.org/news/profess...
- Our study shows Ephrin A1 undergoes conformational selection when binding EphA2, while its juxtamembrane regions stay flexible. These insights clarify bidirectional signaling and may guide future therapeutic strategies. Full text: www.sciencedirect.com/science/arti... #NMR #Ephrin #Cancer #receptor
- Great contribution from our former lab member Robert Silvers in @narjournal.bsky.social ☺️ "Noncanonical RNA binding of human La-related protein 6" Full text: academic.oup.com/nar/article/... #LARP #NMR #RNA #structure
- Take a look at the publication of our former lab member Nina Kubatova in @pnas.org 😇 "Dimerization propensity of the β1-adrenergic receptor in lipid nanodiscs probed by DEER and single-molecule spectroscopies" Full text: www.pnas.org/doi/10.1073/... #DEER #protein #SingleMolecule #GPCR
- Together with the Evanseck Lab, our lab just published the NMR + MD structure of the Omicron SARS-CoV-2 s2m RNA, revealing a pentaloop with remarkable dynamics. Full text: m.rnajournal.cshlp.org/content/earl... #NMR #MD #RNA #SARSCoV2 #structure #dynamics
- At the 2025 meeting of the German focus group of Magnetic Resonance (FGMR, EPR/NMR), Harald Schwalbe, Instruct-director, introduced access possibilities and highlighted the recent installation of the German Instruct centre. @instruct-eric.bsky.social @gdch.de #NMR #EPR #FGMR #GDCh #InstructERIC
- Exciting work from Duchardt-Ferner et al. in NAR: high-res. NMR structure of a tobramycin-responsive riboswitch. Shows a novel aminoglycoside-binding RNA motif with unique RNA-RNA contacts, explaining its exceptional switching efficiency in eukaryotic translation. academic.oup.com/nar/article/...
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- Our newest publication is online! Using fragment-growth guided by NMR spectroscopy, we optimized small molecules targeting SCoV-2 SL1 RNA, integrating solubility, affinity, and specificity to identify translation inhibitors. Full text: pubs.acs.org/doi/10.1021/... #NMR #drugdesign #RNA #SARSCoV2
- Check out our newest chemical shift assignment! 🎉 We used NMR to characterize the SL5a stem-loop from HCoV-229E, a conserved RNA element key to coronavirus RNA translation and replication. doi.org/10.1007/s121... #RNA #NMR #Virology #StructuralBiology #Assignment #Coronavirus
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- Workshop Alert: On July 10, Nathalie Weickgenannt and Laura Buglioni from @angewandtechemie.bsky.social will be at Goethe University Frankfurt to host a Wiley Publishing Workshop. Don’t miss this opportunity to gain valuable insights into scientific publishing!
- New publication is out in @febsopenbio.bsky.social ! 🎉 "NMR screening of low molecular weight inhibitors targeting the papain-like protease (PLPro) of SARS-CoV-2" Full text: febs.onlinelibrary.wiley.com/doi/10.1002/... #screening #NMR #SARS-CoV2 #targeting
- New publication in @narjournal.bsky.social - Using NMR, SAXS & MD, we characterize the dynamic nonaloop of the SARS-CoV-2 Delta s2m RNA, contributing to future ensemble-functional studies of dynamic RNA motifs. Full text: doi.org/10.1093/nar/... #RNA #StructuralBiology #NAR #NMR #MDSimulations
- Let's support the Bethesda Declaration and stand up for science together ✍️ actionnetwork.org/petitions/op...
- A great overview of methods to investigate RNA modifications 😊 onlinelibrary.wiley.com/doi/full/10....
- Prof. José María Carazo has been elected Chair of the Instruct-ERIC Council, with Dr. Evangelia Chrysina as Vice-Chair. Both bring structural biology expertise to further develop European research infrastructure. @instruct-eric.bsky.social instruct-eric.org/news/instruc...
- Another publication on DNA G-quadruplexes in collaboration with the Heckel group is out! 🎉 "Structural Insights into Spare-Tire DNA G-Quadruplex from the Human VEGF Promoter" Full text: pubs.acs.org/doi/10.1021/... #G4 #quadruplex #photocages #NMR #VEGF #structure
- New publication from Robert Silver's lab reporting the NMR assignment of the 5'SL-bound La domain of human La-related protein 6 (HsLARP6). Congratulations! Full text: link.springer.com/article/10.1...
- Congratulations to Hashim Al-Hashimi on his election to the American Academy of Arts and Sciences! We are thrilled to see his outstanding work being recognized. 🔗 news.columbia.edu/news/three-c...
- Check out our latest assignment note 🥳 'NMR characterisation of the antibiotic resistance-mediating 32mer RNA from the 23S ribosomal RNA' Full text: link.springer.com/article/10.1... #NMR #RNA #m6a #Erythromycinmethyltransferase
- Check out our latest publication on DNA G-quadruplexes! We show how the ligand Phen-DC3 modulates the folding of the human telomeric repeat 23TAG DNA, providing insights into the modulation of G4 folding. Read more here 👉 doi.org/10.1002/chem... #DNA #GQuadruplex #folding #kinetics #realtime #NMR
- Two of our publications are among the most widely read papers in Chemistry and ChemMedChem! 🤩🎉 #EPHA2 #colorectalcancer #drugdiscovery Full text here: chemistry-europe.onlinelibrary.wiley.com/doi/full/10.... chemistry-europe.onlinelibrary.wiley.com/doi/full/10....
- The newest collaboration project has been published! Congrats to the group of @m-grininger.bsky.social 🥳 'Protocol for the purification, analysis, and handling of acyl carrier proteins from type I fatty acid and polyketide synthases' Full text link: www.sciencedirect.com/science/arti...
- In February 2025, Instruct-ERIC Director Prof. Harald Schwalbe visited the Instruct-ERIC center in Israel. Visit here for the full report: instruct-eric.org/news/focus-o...
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- 🎓 PhD Opportunity at DTU! 🎓 Join the TargetRNA MSCA doctoral network to advance RNA-ligand design with NMR & X-ray crystallography! 🌍🔬 Apply by: 2 April 2025 📍 Kemitorvet, Kgs. Lyngby, 2800, Denmark 🔗 Apply now: efzu.fa.em2.oraclecloud.com/hcmUI/Candid... #PhD #NMR #RNAResearch #JobAlert #DTU
- Have a look at our newest commentary in @pnas.org : "G-quadruplexes and their unexpected ability to fold proteins" Full text: www.pnas.org/doi/10.1073/... #G4 #quadruplex #proteins #folding
- Check out the newest publication from our group: "Nanosecond Hyperquenching, a Novel Method of Specimen Preparation for Electron Cryo-Microscopy" Full text: chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1... #time-resolved #ECM #NHQ
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- A new NMR assignment letter is online! Take a look at the secondary structure of the E.coli guanidine-II riboswitch! Full text: doi.org/10.1007/s121... #nmr #RNA #riboswitch #structure
- Congratulations to Betül and co-workers for this great work 🥳 "Optimization of Structure-guided Development of Chemical Probes for the Pseudoknot RNA of the Frameshift Element in SARS-CoV-2" Full text: doi.org/10.1002/anie... #nmr #SARS-CoV2 #rna #drugtargeting
