Have a look into our newest publication showing how GS-441524 derivatives can potently inhibit the SARS-CoV-2 macrodomain (Nsp3b), offering a structural roadmap for next-generation antiviral design.
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
#SARSCoV2 #NMR #drugtargeting #synthesis
Structure‐Based Rational Design of a Selective Hydrolase Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus‐2 Nsp3 Macrodomain
Structure-guided design of a sulfamoyl-modified analog of GS-441524 yielded a selective, high-affinity inhibitor of the SARS-CoV-2 macrodomain Nsp3b. The compound occupies the phosphate-binding pocke...
chemistry-europe.onlinelibrary.wiley.com 