Josh Brickman
Developmental and Stem Cell Biologist, interested in all things gene regulation. Transcription, lineage specification, potency and plasticity.
- Looking forward to Naama Barkai's visit tomorrow - all in copenhagen interested in biological specificity should come to hear her talk tomorrow!!!!
- Very happy to see this nice collaboration with @niakanlab.bsky.social bear fruit. Beautiful work by @clairesimon.bsky.social culturing human embryos in the presence of FGF/ERK stimulation/inhibition. www.nature.com/articles/s41...
- We used our deep learning models that were originally published in www.nature.com/articles/s41...
- Our model suggests that a few cells can partially differentiate, forming early endoderm that still expresses some epiblast markers - this could be due to the differences in timing of the two binary cell fate choices in preimplantation development between mouse and human.
- Contributions from our side, Martin Proks @nazsalehin.bsky.social and Madeleine Linneberg-Agerholm, whose original in vitro finding are validated in this paper - journals.biologists.com/dev/article/...
- Back from the ISDB, Clearly my presence in the lab was missed!
- Why combat aging with enhancers at 11? Why not just make 10 louder? It wouldn't be 11. For transcription, all the other processes (translation, splicing etc) are on ten, on ten, etc…where do they go? For Enhancers, everything on ten, the transcription factors deacetylate and go one higher, 11.
- Issue 11 N&V: fibroblast dynamics during mammary oncogenesis RIPK1 oligomers at core of CD95 necrosomes Autophagosomes as hub for AKAP regulation of neuronal PKA Centipede neurotoxin reveals new mode of Nav channel modulation Cover: @josh-brickman.bsky.social et al www.embopress.org/toc/14602075...
- Another chapter from Martin Proks PhD. The first chapter in our nf-core saga and a new pipeline for MARS-seq! academic.oup.com/bioinformati...
- Very nice paper - all principles at the heart of molecular biology although the logic with which evolution implements them was a mystery.
- Out in Cell @cp-cell.bsky.social: Design principles of cell-state-specific enhancers in hematopoiesis 🧬🩸 screen of fully synthetic enhancers in blood progenitors 🤖 AI that creates new cell state specific enhancers 🔍 negative synergies between TFs lead to specificity! www.cell.com/cell/fulltex... 🧵
- Alba Redo Riveiro - an amazing PhD student. One chapter in her PhD is described here. It was a great paper and a very long evolving story - www.cell.com/stem-cell-re...
- The Stem Cell Reports Best Of 2024-2025 issue is out now! Read the full issue to explore the most notable papers published over the last year. stemcellreports-bestof2024-2025.elsevierdigitaledition.com @isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social
- Very excited to see Melissa elected to the Royal Society. Nice triumph for old school developmental biology entering the modern world of translation. Way to go Melissa!!!! renew.ku.dk/latest-news/...
- And here I was thinking I need to modernize my references with Taylor - perhaps the Last Dance is further away then we think!
- Congrats Josh! Was just thinking of you while listening to this new Mekons session. Your ##PaperThemeTune can be the first track: it lacks chromatin, but does contain an age-appropriate dose of nostalgia... www.bbc.co.uk/sounds/play/...
- Two days left to apply to do fantastic science in a great place - come join us as a new group leader at reNEW - employment.ku.dk/faculty/?sho...
- How does metabolism act through generic chromatin modifiers promote specific cellular states? Simultaneous modification of transcription factors and chromatin, enhancing epigenetic signal to noise ratios. www.embopress.org/doi/full/10....
- Essentially, we tried giving cells their own variation on Ozempic…Galactose. In the case of ESCs, we bypass the brain and substitute galactose for glucose the media…they become super stem cells.
- Super ESCs, rejuvenated ESCs, enhanced lipid metabolism leads to elevated NAD and activated SIRT1
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View full threadThis enhanced or deteriorating ratio of epigenetic signals may also underpin aging. Amazing work by Robert Bone @alboo87 , @molly_lowndes and Collaborators @treebak and Michael Nielsen, all of @LabBrickman in @reNEW_Global @UCPH_health
- Reposted by Josh BrickmanAltering metabolism programs cell identity via NAD+-dependent deacetylation @josh-brickman.bsky.social et al show enforced OXPHOS dependence in embryonic stem cells drives deacetylation of essential transcription factors & inner-cell-mass-like gene expression www.embopress.org/doi/full/10....
- Really looking forward to a day in Sheffield - one of the first places In the world to work with human pluripotent cells!
- Today we welcome Josh Brickman @josh-brickman.bsky.social from reNEW at the University of Copenhagen, who will present his work on transcription factors and cellular memory. Alfred Denny Conference Room, 1 pm. All welcome! Host: Anestis Tsakiridis @tsakiridis.bsky.social
- Reposted by Josh BrickmanPRC2 promotes canalisation during endodermal differentiation journals.plos.org/plosgenetics... @Robertillingwo7 @wbickmor.bsky.social @josh-brickman.bsky.social
- Transcription ahead of chromatin regulation? Activation in endoderm occurs prior to K27me3 removal, plus much more. A tribute to our amazing collaborators @wbickmor.bsky.social and the amazing Rob Illingworth, without whom this data would have gathered dust! journals.plos.org/plosgenetics...
- What does PRC2 do? It keeps the differentiation train on the rails, insuring lineage fidelity!
- Reposted by Josh BrickmanSuperb work by Wouter @Zouters & @OlgaPushkarev developing ChromatinHD, two scale-adaptive #machinelearning models & interpretation tools that use #scRNAseq + #scATACseq data to better understand how chromatin accessibility relates to gene expression doi.org/10.1038/s414... Happy 2025 everyone 🎆 !
- In the next few weeks we will start advertising for PhD students and/or post docs. We are looking for two people to join our group, one focused in pancreatic organoids and the other to join our computational team. DM if you are interested in coming to @ucph.bsky.social
- Reposted by Josh BrickmanWe have an amazing programme with fantastic speakers! @chribue.bsky.social @wbickmor.bsky.social @robklose.bsky.social @mariekeoudelaar.bsky.social @eileen-furlong.bsky.social @josh-brickman.bsky.social @parinazmehdipour.bsky.social @edchuong.bsky.social @jorge-ferrer.bsky.social @helink.bsky.social
