Superb work by Wouter @Zouters & @OlgaPushkarev developing ChromatinHD, two scale-adaptive
#machinelearning models & interpretation tools that use
#scRNAseq +
#scATACseq data to better understand how chromatin accessibility relates to gene expression
doi.org/10.1038/s414...
Happy 2025 everyone 🎆 !
ChromatinHD connects single-cell DNA accessibility and conformation to gene expression through scale-adaptive machine learning - Nature Communications
Functional chromatin changes occur at different scales. Here, the authors introduce ChromatinHD, a method that characterises differential and predictive chromatin accessibility changes in a scale-adap...
