Rob Klose
Professor of Genetics
Department of Biochemistry
University of Oxford
kloselab.co.uk
- Reposted by Rob KloseVery excited to share our new Molecular Cell paper on missense mutations in Polycomb genes and how they can disrupt chromatin regulation to drive neurodevelopmental disorders. A huge thank you to everyone involved, and to our amazing collaborators! www.cell.com/molecular-ce...
- Reposted by Rob KloseSpring vibes
- Reposted by Rob KloseYesterday we came together to honour Professor Raymond Dwek through the naming of the Raymond Dwek Seminar Room. Raymond's family (pictured) joined the celebration and Raymond was visibly touched, saying: "Thank you for this amazing gesture. I'm humbled by it, but I will treasure it."
- Reposted by Rob KloseThis Friday (today), we’re pleased to welcome Melike Lakadamyali (@melikel.bsky.social) from @upenn.edu. If you are interested in Super resolution microscopy, cytoplasmic and nuclear organization with a focus on biophysics, then do not miss Prof. Lakadamyali talk in our lecture hall at 13:00. 🤗
- Reposted by Rob KloseOur new preprint on SMCHD1! We’ve shown SMCHD1’s ATPase activity is critical for function in vivo, and excitingly a new DNA binding domain neighbouring the ATPase domain activates the enzymatic function, which is important for normal chromatin binding. urldefense.com/v3/__https:/...
- Reposted by Rob KloseWe're launching a research lab at SMART. Shenzhen Medical Academy for Research and Translation is a newly established institute with long-term funding mechanisms for internal and external investigators. At full capacity SMART aims to support up to 400 labs. www.scmp.com/news/china/s...
- Reposted by Rob KlosePlease share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine. faculty-einstein.icims.com/jobs/17847/a...
- Reposted by Rob KloseLovely lab hike in Werribee Gorge to celebrate the EckMasLab’s 5th birthday 🎂
- Reposted by Rob KloseOut now in @natureportfolio.nature.com: PARM reveals gene regulation is far more predictable than thought. Lightweight, cell‑type specific, and experimentally validated. Enables functional prediction of regulatory mutations with just one dish of cells + one day of compute. ➡️ doi.org/10.1038/s415...
- Reposted by Rob KloseExciting news! The lab is moving to Colorado at @cuanschutz.bsky.social 🎉 We’ll be recruiting at all levels—stay tuned!
- Reposted by Rob KloseFinal version of our paper now published. elifesciences.org/articles/109... Take homes: CHD4/NuRD directly limits transcription factor residence times. At active enhancers this keeps them working efficiently. At inactive enhancers it prevents TFs from getting a foothold and causing activation. 1/n
- Reposted by Rob Klosewww.nature.com/articles/s41... happy i could be a part of this paper from the Gilan lab out now. Along with many other things, it provides strong evidence of chromatin memory for gene activation, and suggests that DOT1L is the missing link balancing the fast and slow arms of the MLL/Polycomb axis
- Reposted by Rob KloseIt’s out! 🥳 Excited to share our new paper (with Kai Walstein, @andrea-musacchio.bsky.social and all others) on the role of M18BP1 in CENP-A loading! “M18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humans” link.springer.com/article/10.1...
- Reposted by Rob KloseDont miss out on it ! Hands on Summer School. Cut&Run, Cut@Tag, ChIP, ATACseq and analyse your own data ! ➡️Unique opportunity ! 14 exiting days ➕ Daily high profile lectures. 👉 Applications & info: bit.ly/4oGDR8f
- The Epigenetics Community at #HelmholtzMunich, together with #Abcam, is hosting the 3rd #Chromatin #SummerSchool in Munich: 📆 17–29 August 2026 ⏰ Apply by March 29, 2026 👉 Applications & info: bit.ly/4oGDR8f @epihmgu.bsky.social @metorrespadilla.bsky.social @robertife.bsky.social
- Reposted by Rob KloseI started offering career advice to two junior colleagues today in separate meetings, and both times I caught myself thinking that, if I'm honest, I don't have very good advice on navigating the current funding and job climate. I think it's important to say that no one does.
- Reposted by Rob KloseThis just in. So honored and grateful...
- We're proud to join the Vilcek Foundation in recognizing HHMI Investigator Karolin Luger, whose dedication & groundbreaking nucleosome research has led to the development of innovative new drug treatments, including cancer medicines. hhmi.news/49VciEd @vilcekfoundation.bsky.social
- Reposted by Rob Klose🧬📄 Preprint update (v2): We added new biochemical experiments that clarify how IWS1 associates with the transcription elongation complex and further define competition between IWS1 and RECQL5. 🧪⚙️ www.biorxiv.org/content/10.1... Structural model is already available in the PDB (9MLC).
- Reposted by Rob KloseA gift of an article from the inimitable Colin Kleanthous as he says a moving farewell to his laboratory. A brave, unrepentant and scientifically brilliant journey is described - please have a read, friends. www.jbc.org/article/S002...
- Reposted by Rob KloseI’m the only one at this minute leaving Montreal to the US. Gee wonder why that is… (photo of customs an immigration line)
- Reposted by Rob KloseIs it just me, or has publishing become ultra slow in the last 5 years?
- Reposted by Rob KloseCongratulations to the Maths and Computing Suffrage Science 2026 cohort of awardees 👏 👏 👏 🎉 These distinguished women were all recognised by peers as pioneers, leaders and inspirational role models. We salute you! Read all about the awardees ⬇️
- Reposted by Rob KloseThe boss tries to run one simple PCR just to chip in a bit, and this is the reaction from the lab 😂
- Congratulations Hannah and team!
- 📣 I'm excited to share our latest preprint! We adapt and characterise a neurosphere-based CNCC differentiation protocol, and demonstrate utility for quantitative phenotyping and craniofacial disease modelling! 🧫 Read about Array-CNCC here: www.biorxiv.org/content/10.6... @uoe-igc.bsky.social
- Reposted by Rob Klose#FragileNuclesome is back tomorrow! Join us to hear about exciting talks from: - @au-ho-yu.bsky.social in @robklose.bsky.social's group about transcriptional control by SET1/MLL complexes - @gcloner.bsky.social at @epicypher.bsky.social about the histone PTM landscape of the immune system
- 🥁 #FragileNucleosome is back on Jan 28! We are very excited to host @au-ho-yu.bsky.social and @gcloner.bsky.social as our first speakers of 2026! 📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
- Reposted by Rob KloseLike the genetic code, bitcoin, or national borders, our methods for evaluating science are a "frozen accident": things that were formed from historical circumstances rather than careful design, and that persist not because they are optimal, but because replacing them is extraordinarily difficult.
- Reposted by Rob Klose🥁 #FragileNucleosome is back on Jan 28! We are very excited to host @au-ho-yu.bsky.social and @gcloner.bsky.social as our first speakers of 2026! 📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
- Reposted by Rob KloseMy grandmother immigrated from Lunenburg, Nova Scotia, our relatives include Angus Walters, captain of the famed Bluenose fishing and racing boat. Proud of our Canadian heritage. youtu.be/flsgJe8mN-A?...
- Reposted by Rob KloseCryo-EM structure reveals how influenza A virus NEP binds the viral polymerase at a regulatory hotspot, coordinating RNA synthesis and nuclear export. Fantastic collaboration with @loiccarrique.bsky.social and Jon Grimes. www.science.org/doi/10.1126/...
- Reposted by Rob Klose🚨Postdoc opportunity🚨Our lab at MRC-LMB Cambridge is recruting a postdoc to study transcription-coupled splicing using cryoEM and endogenous isolation! 🔬 🧬 Please feel free to get in touch directly #postdoc #cryoEM #biochemistry #splicing Apply here by 11 Feb www.nature.com/naturecareer...
- Reposted by Rob KloseJoin our division of Structural Studies at @mrclmb.bsky.social in the wonderful group of @suyangzhang.bsky.social!
- 🚨Postdoc opportunity🚨Our lab at MRC-LMB Cambridge is recruting a postdoc to study transcription-coupled splicing using cryoEM and endogenous isolation! 🔬 🧬 Please feel free to get in touch directly #postdoc #cryoEM #biochemistry #splicing Apply here by 11 Feb www.nature.com/naturecareer...
- Reposted by Rob Klose📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere. 🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
- Reposted by Rob KloseProud to be Canadian 🇨🇦 www.cbc.ca/news/politic...
- Reposted by Rob KloseClever new method for assembling DNA oligos into larger sequences without the need for unique overlap sequences. Can't wait for those 'this sequence is too complex' rejection messages from DNA suppliers to become a thing of the past. 🧬🧪 www.nature.com/articles/s41...
- Reposted by Rob KloseWe had a super interesting seminar by Giacomo Cavalli (@cnrs.fr | @umontpellier.bsky.social), today. 🤩 … with exciting data and results by the Cavalli on epigenetic memory of past events that get mediated by Polycomb components & #histone #acetylation. Thanks to @iovino-lab.bsky.social for hosting!
- Reposted by Rob KloseCome to hear Alan's great new story on SET1/MLL proteins and transcription next Wednesday. @fnucleosome.bsky.social
- 🥁 #FragileNucleosome is back on Jan 28! We are very excited to host @au-ho-yu.bsky.social and @gcloner.bsky.social as our first speakers of 2026! 📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
- Reposted by Rob KloseDelighted to be in Edinburgh visiting the Institute of Genetics and Cancer today! Great to chat gene regulatory logic and development. Many thanks to @hannahlong.bsky.social and Jenny Nichols for hosting me, owner of the world’s best collection of ornamental office mice
- Reposted by Rob KloseNew lab paper!! We develop a technology for real-time, single-molecule visualization of proteasomal substrate degradation in cells. We find that the site of substrate engagement by the proteasome determines decay kinetics, efficiency and co-factor requirement. www.biorxiv.org/content/10.6...
- Reposted by Rob KloseThe word 'leverage' in biomedical literature (as search by Pubmed trends). I wonder what is behind it. Every other abstract I read now seems to be leveraging.
- Reposted by Rob Klose⚠️ The final work of two former PhD students Till @tschwammle.bsky.social and Verena @verenamutzel.bsky.social is out! ➡️⬅️ They dissect how memory can arise from antisense transcription using mathematical modelling 💻, genomics 🧬 and synthetic biology ⚒️! link.springer.com/article/10.1...
- Reposted by Rob KloseTomorrow! ☺️
- Next week, we welcome Giacomo Cavalli from @cnrs.fr | @umontpellier.bsky.social. He joins our Special Guest Seminar Series to give a talk on »Epigenetic memory of past events mediated by modification of Polycomb components & histone acetylation« Thanks to @iovino-lab.bsky.social for organizing. 🤗
- Reposted by Rob KloseHappy New Year all. I know it's been a draining and difficult year for science in general, but wanted to share some good news: our intrabody paper has now been published in Science Advances with lots of additional data. www.science.org/doi/10.1126/...
- Reposted by Rob Klose📢 One more week to go... exciting fully funded #PhD position for UK candidates to work across #ICR and #Imperial on novel mechanisms in genome stability and #CancerResearch. #PhDStudentship #LifeSciences #DNAReplication #CRISPR
- We are recruiting a PhD student to tackle a fundamental question in cancer biology: how DNA replication fails at centromeres and drives chromosomal instability (CIN) — a major driver of tumour evolution and therapy resistance. tiny.cc/vilw001 #PhD #CancerResearch #GenomeStability #Chromatin
- Reposted by Rob KloseCheck out our latest study on the PfRIPR protein, essential for the malaria parasite to get inside our blood cells. We show how antibodies block the function of PfRIPR by preventing its flexible hinges from bending, or by stopping it from compacting as part of its mechanism.
- Reposted by Rob Klose'This video is the culmination of several yrs attempting to: (1) Figure out best practices for modeling ptn-ptn interactions; (2) Understand the outputs of programs like AlphaFold & adjacent software including quantitative metrics;(3) Communicate my thoughts to unwitting victims through workshops'
- Reposted by Rob KloseOne good way to investigate what causes that feeling: experimentally truncate a good story before the point where its creator actually ended it. Just cut it off and observe your reaction to that imposed ending. The resulting feeling will tell us something about what's missing.”
- Reposted by Rob KloseA wonderful collaboration between Jess Tyler lab, @epicypher.bsky.social, @gcloner.bsky.social, James Kadonaga and our lab at PSU. In this article, we provide the significance of the nucleosome acidic patch. doi.org/10.64898/202...
- Reposted by Rob KloseCongrats JP, Mike and Jess and colleagues on the paper. Very interesting work.
- A wonderful collaboration between Jess Tyler lab, @epicypher.bsky.social, @gcloner.bsky.social, James Kadonaga and our lab at PSU. In this article, we provide the significance of the nucleosome acidic patch. doi.org/10.64898/202...
- Reposted by Rob KloseNature research paper: A nowhere-to-hide mechanism ensures complete piRNA-directed DNA methylation go.nature.com/4pDVgPq
- Reposted by Rob KloseOnce again I'm more than happy to accept invitations to talk in Edinburgh and the North of England in July 2027. In fact, let's get a group together to tour all of these towns. Who's in? #TourdeTourdeFrance www.theguardian.com/sport/2026/j...
- Reposted by Rob KloseFinal reminder: abstract deadline today for the @bsdb.bsky.social 2026 meeting! Don’t miss it :) 👇👇👇 bsdb.org/meetings/
- I am absolutely delighted to share the invited speakers for our upcoming @bsdb.bsky.social "Molecules to Morphogenesis" meeting! Registration and abstract submission is now open - join us! bsdb.org/meetings/ March 23-26, 2026 - UK
- Reposted by Rob KloseCongratulations to @groth-anja.bsky.social on receiving the Novo Nordisk Foundation Jacobæus Prize 🏆 we’re proud to see Anja's mentorship, leadership, & pioneering work in epigenetic cell memory getting top recognition 👏 celebrating the contributions of past & present lab members to this work too 🥳
