Mathieu Lupien
Senior scientist @Princess Margaret Cancer Centre, Prof @UofT. BHAG: Conquer cancer by treating it as a disease of the chromatin. lupienlab.uhnresearch.ca
- New study from Dr. Hansen Housheng He’s team, thrilled that we contributed, on functional mapping of m6A in cancer at scale with implications for novel target discovery and future therapeutic development. www.nature.com/articles/s43...
- Reposted by Mathieu Lupien[Not loaded yet]
- Hot from the press: Using single-cell chromatin accessibility and gene expression across ~300,000 cells, we show that prostate cancer dissemination involves phenotypic plasticity over clonal selection, with malignant cells converging toward an inflammatory-like state during lymph node spread.
- Back-to-back: Integrating single-nuclei RNA-seq and whole-genome sequencing, @joachimwei.bsky.social and his team show how prostate cancer metastasis is shaped by plasticity-driven convergence alongside ongoing clonal evolution, with distinct clones adopting shared transcriptional trajectories.
- Reposted by Mathieu LupienA major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...
- Reposted by Mathieu LupienExciting new conference!
- 🔔 Don’t forget: Abstract submissions for #CBHC2026 are open! 🗓️ Deadline: Feb 12, 2026 📥 Submit here: f.mtr.cool/oftnlpqjlg
- Reposted by Mathieu LupienConfused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
- Our lab website just got a major refresh to better present: Our research philosophy: why chromatin is central to our work. A snapshot of our culture: diverse, collaborative, impact-driven. Our priorities: how we translate discoveries into clinical reality. Check it out
- Reposted by Mathieu Lupien[Not loaded yet]
- Lest We Forget N'oublions Jamais
- DNA replication is only half the story. Cells actually replicate their chromatin, ensuring that both the DNA sequences and the chromatin states are faithfully maintained to preserve cell identity and function after division. Here's a glimpse of how this process unfolds, courtesy of theCrux:
- Reposted by Mathieu LupienFantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...
- Reposted by Mathieu LupienWe have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.
- Reposted by Mathieu LupienWonderful opportunity to work with Martin Howard and my group trying to understand how chromatin influences gene transcription and expression. Integration of theory, modelling, and experimentation. Come and join the team! Please repost! jobs.jic.ac.uk/Details.asp?...
- Reposted by Mathieu Lupien❓Can a father’s environmental exposures before conception influence their offspring? We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences www.embopress.org/doi/full/10....
- Reposted by Mathieu LupienExciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!
- Every so often, a paper lands at exactly the right moment. This one’s a gem. Can’t wait to try out this new strategy for delivering CRISPRoff chromatin-editing tools into our favorite cellular model system. Congrats to James K Nuñez and his team: www.nature.com/articles/s41...
- Reposted by Mathieu LupienExcited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....
- Reposted by Mathieu Lupien[Not loaded yet]
- One often hears that DNA is the blueprint of life. Today, I read a really nice paper that begins with "proteins are the cornerstone of life". By that logic, I might start referring to RNA as the scaffold, and chromatin as the framework that shapes it all. Regardless, the paper is a must-read:
- Nice study showing how DNA mutagenesis can be driven by transcription factor (TF) competition with mismatch repair machinery: www.cell.com/cell/fulltex... Worth considering alongside the uneven mutagenesis of TF cistromes tied to their cancer-type-specific essentiality: www.cell.com/cancer-cell/...
- Reposted by Mathieu LupienGreat opportunity to join the vibrant developmental biology in Toronto (and boss around me and @wbderry.bsky.social). jobs.sciencecareers.org/job/673968/p...
- A jewel of a presentation on the history of chromatin. Always a pleasure to go back in time with those who helped shape it. I am grateful for the insights and stories shared by Drs. Ada and Donald Olins. youtu.be/QExPH1bVbGU
- Less than a month to go until the GRC on Hormone-Dependent Cancers! Looking forward to reconnecting with the community and sharing our latest on epigenomics of ecDNAs in tumor evolution. www.grc.org/hormone-depe...
- Reposted by Mathieu LupienAre you currently in the ERE related field & want to find new collaborative opportunities? Join our Chairs @chiappinellilab.bsky.social, @shenhui1986.bsky.social, Ting & Tao at #EREHD25 this Nov! 🎙️Talk Submission extended to 03 Sept 💰Final few $500 grants remaining Don't Miss out! bit.ly/4eRq9Mp
- If you're into super-resolution microscopy, check out the new story from Myles Brown's lab showing how chromatin architecture responds to hormone signaling at enhancers. Dynamic, ligand-dependent changes in H3K27ac structure with implications for endocrine resistance. www.biorxiv.org/content/10.1...
- Reposted by Mathieu Lupien[Not loaded yet]
- Reposted by Mathieu Lupien📣 We’re recruiting 1-2 Group Leaders! NCMBM is looking for early-career researchers ready to establish their independent research groups! 🧬 With an attractive start-up package, help us shape the future of molecular biosciences and medicine in 🇳🇴 and be part of the @nordicembl.bsky.social!
- Reposted by Mathieu Lupien[Not loaded yet]
- Reposted by Mathieu Lupien[Not loaded yet]
- Reposted by Mathieu Lupien[Not loaded yet]
- Reposted by Mathieu Lupien[Not loaded yet]
- Reposted by Mathieu LupienRegistration is now OPEN for the 11th Canadian Conference on Epigenetics! The annual meeting will be held November 12-15, 2025 at the Banff Centre in Banff, Alberta. You can register and find out more information at our website: event.fourwaves.com/ceehrc2025
- Reposted by Mathieu LupienIn about a week we (Biological Sciences @ Monash Uni in Melbourne, Australia) will be opening a search for 3 (!!!) permanent academic positions (40% research, 40% teaching, 20% service) at Lecturer/Senior Lecturer. 1 Genomics, 2 Ecology. Please share, email me, DM, follow, send carrier pigeons…
- Bonne Saint-Jean à toutes celles et ceux qui portent dans leur cœur la francophonie et toute la richesse de sa culture!
- Whether you're in research, medicine, or industry, the Epigenetics and Epigenomics in Health and Disease meeting will be the place to connect, share, and explore the latest advances in epigenetics and disease in the fall. Register early to secure your spot: www.xcellsconferences.com/epigenetics2...
- Reposted by Mathieu Lupien[Not loaded yet]
- Reposted by Mathieu Lupien🚨 New meeting this fall in Brussels! 🚨 Cutting-edge science, amazing colleagues, & a RARE career development workshop for trainees-covering pharma, consulting, writing, start-ups & more 🤩 #epigenetics2025 Registration is open!! @epicypher.bsky.social xcellsconferences.com/epigenetics2025
- Reposted by Mathieu Lupien[Not loaded yet]
- 1/ What a week! The 2025 GRC on Cancer Genetics and Epigenetics just wrapped up. I'm still energized by the phenomenal science, deep discussions, and vibrant sense of community. 🔗 www.grc.org/cancer-genet... #GRCCancerGenetics #Epigenetics
- 2/ This meeting was packed with cutting-edge research and insightful exchanges. But maybe most importantly, it was an incredibly welcome chance to reconnect with old friends, long-time colleagues, and so many new faces shaping the future of our field.
- Safe travels to everyone making their way to the Gordon Research Conferences Cancer Genetics & Epigenetics conference! Can’t wait for the incredible science, inspiring conversations, and new connections ahead. Let’s keep pushing boundaries. Together, we’re making a difference!
- Reposted by Mathieu Lupien[Not loaded yet]
- Must read if you're interested in the conditions that make cells susceptible to transformation. In this case, the shortest cell cycle time = the highest risk. Across tissues and mutations, pace, not just mutations, defines vulnerability. rdcu.be/ekc8U
- Reposted by Mathieu Lupien[Not loaded yet]
- Reposted by Mathieu Lupien[Not loaded yet]
- Reposted by Mathieu Lupien[Not loaded yet]
- Reposted by Mathieu Lupien[Not loaded yet]
- Reposted by Mathieu Lupien[Not loaded yet]
- Reposted by Mathieu LupienWe have a postdoctoral opening for a researcher with experience in bioinformatics of DNA sequencing and machine learning to work on the development of new methods for cancer diagnostics related to nucleosomes, chromatin and beyond www.jobs.ac.uk/job/DMK060/s.... Application deadline: 21st April 2025
- Reposted by Mathieu Lupien[Not loaded yet]
- Reposted by Mathieu Lupien[Not loaded yet]
- Reposted by Mathieu LupienIf you’re interested in moving your lab to beautiful Montreal Canada, this program offers chairholders funding of up to 1M$ a year for 8 years. See link for details. www.nature.com/naturecareer...
- Reposted by Mathieu Lupien[Not loaded yet]
- Reposted by Mathieu Lupien[Not loaded yet]
- Reposted by Mathieu Lupien[Not loaded yet]
- The latest research from the He Lab (www.hansenhelab.org) reinforces the importance of integrating epigenomic assays into clinical practice to enhance cancer patient care. Congratulations to the entire team! @uhnresearch.bsky.social @pmresearch-uhn.bsky.social doi.org/10.1038/s415...
- Reposted by Mathieu Lupien
We are recruiting a Principal Investigator in Computational Biology at @oicr.on.ca: oicr.bamboohr.com/careers/378. This position is in downtown Toronto, adjacent to the University of Toronto where your university appointment would be. Please contact me if you have any questions! - Reposted by Mathieu Lupien[Not loaded yet]
- Reposted by Mathieu Lupien[Not loaded yet]
- Reposted by Mathieu Lupien[Not loaded yet]
- Reposted by Mathieu Lupien[Not loaded yet]
