Aleksander Szczurek
Researcher @UniofOxford in single molecule imaging of gene regulation at @RobKlose lab
I paint: aleksanderszczurek.wixsite.com/ats-art
- Our man Alan speaking about his latest story! Make sure to join
- 🥁 #FragileNucleosome is back on Jan 28! We are very excited to host @au-ho-yu.bsky.social and @gcloner.bsky.social as our first speakers of 2026! 📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
- Reposted by Aleksander SzczurekUsing degron technology to systematically deplete all SET1/MLL complexes, we find that they synergise to deposit H3K4me3 at gene promoters. Using mass spectrometry (thanks to Inge de Krijger and Michiel Vermeulen), we also identify a novel SET1B isoform that contributes substantially to H3K4me3.
- Reposted by Aleksander SzczurekExcited to share our new preprint from the Klose lab, where we investigate how SET1/MLL complexes shape H3K4me3 and regulate transcription in mouse ES cells. www.biorxiv.org/content/10.6...
- Reposted by Aleksander SzczurekAlso @au-ho-yu.bsky.social probably holds the world record for the most degron-tagged proteins in the same line. Guess how many!
- Reposted by Aleksander SzczurekAn early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost! www.biorxiv.org/content/10.6...
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- Reposted by Aleksander SzczurekA new, nerdy paper. We figured out (some) of the rules underlying cell-permeability of probes and designed ligands that light up, grab, and move proteins around. Awesome @hhmijanelia.bsky.social x @uwmadison.bsky.social x @stjuderesearch.bsky.social collaboration! www.pnas.org/doi/10.1073/...
- Reposted by Aleksander Szczurek🧬 New preprint! SNU-Seq maps nascent transcription at single-nucleotide resolution using 4sU labeling. Together with sf4sU-Seq, it shows how epigenetically primed chromatin rapidly activates transcription after IFN-γ. 📄 doi.org/10.1101/2021... #SNUSeq #RNAseq
- Reposted by Aleksander SzczurekI’m a fair-weather poster on here to say the least. However, I'm pleased to present our latest paper. A great effort from all authors and an interesting insight into transcriptional regulation (we think!). www.cell.com/molecular-ce...
- Reposted by Aleksander SzczurekBIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
- If you are a computational biologist come, apply and join Howard & Klose lab in a joint Norwich-Oxford collaboration on chromatin dynamics!
- VACANCY - We have an opportunity for a Postdoctoral Researcher to join the Howard Group, working to develop computational models of epigenetic dynamics in the Polycomb system. www.jic.ac.uk/vacancies/po... Closing date - 9 November 2025 Salary - £37,500 - £45,350 Contract - 36 months, full-time
- Reposted by Aleksander SzczurekIf you are a computational biologist interested in how chromatin states are established and maintained to regulate transcription, this is the dream job for you! This will be in close collaboration with the Klose lab in Oxford and we have a lot of cool projects you can get involved in. Apply!
- VACANCY - We have an opportunity for a Postdoctoral Researcher to join the Howard Group, working to develop computational models of epigenetic dynamics in the Polycomb system. www.jic.ac.uk/vacancies/po... Closing date - 9 November 2025 Salary - £37,500 - £45,350 Contract - 36 months, full-time
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- Reposted by Aleksander SzczurekDelighted to share our lab's first preprint identifying DDIAS as a mitotic DNA repair protein. Great collaboration with the @andrewblackford.bsky.social, @tcr-miller.bsky.social and @profstewartlab.bsky.social labs, and many more. Read the paper here: www.biorxiv.org/content/10.1...
- Reposted by Aleksander SzczurekDouble celebration on our floor @oxfordbiochemistry.bsky.social with @guifengwei.bsky.social from the Brockdorff lab and Dounia and Sherry from Fisher lab having their papers published today! And I hear there is more to come... www.nature.com/articles/s41... www.nature.com/articles/s41...
- Reposted by Aleksander SzczurekDo you know where transcription of a gene actually stops? Hint: it is not the annotated gene end. In our new paper in Nucleic Acids Research we argue that phosphorylation on threonine 4 of RNA Pol II CTD is a marker of transcription termination in animals... 🧵 academic.oup.com/nar/advance-...
- Reposted by Aleksander SzczurekCheck out our new collaborative preprint about Affinity-ligand purification of native human low-abundance multi-protein complexes doi.org/10.1101/2025...
- Reposted by Aleksander SzczurekRegistration for Transcription and Chromatin UK is OPEN! Taking place from September 17 to 19, 2025, this conference will showcase cutting-edge research and is a ‘must-attend’ event for the UK transcription and chromatin community & both at home and abroad. Pl register ow.ly/7QQb50W9Alo & share
- Reposted by Aleksander SzczurekFresh preprint by @flavia-con.bsky.social from our lab uncovers how SMCHD1 finds & binds chromatin using live-cell single-molecule imaging🔬 She reveals how SMCHD1 dynamically engages chromatin, including the inactive X chromosome, to maintain gene silencing. www.biorxiv.org/content/10.1...
- Check out new paper on single-molecule live-cell imaging of SMCHD1 binding to an inactive X chromosome by Flavia Constantinescu from Neil Brockdorff's team! :)
- Reposted by Aleksander SzczurekAlso noted: The first two blastomeres contribute unequally to the human embryo. www.cell.com/cell/fulltex...
- Reposted by Aleksander SzczurekAll you nuclear biologists out there: Here is a cautionary tale not to be fooled by peripheral organelle staining. It might just be that your antibody got trapped because it is "too good".
- 🚨 Preprint alert 🚨 Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇 doi.org/10.1101/2025...
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- Reposted by Aleksander Szczurek🧵 1/6 Just dropped in @naturecomms.bsky.social We’ve engineered the most photostable yellow fluorescent proteins (YFPs) to date—mGold2s and mGold2t—with up to 25× greater photostability than mVenus and mCitrine, without compromising brightness. 👇 🔗 www.nature.com/articles/s41...
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- Cool perspective on cohesin as a "disruptor" by Adrian Bird: www.cell.com/molecular-ce...
- Reposted by Aleksander SzczurekOur new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social! Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩 www.sciencedirect.com/science/arti...
- Reposted by Aleksander Szczurek📣 We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬🧪
- Reposted by Aleksander SzczurekVery interesting finding!
- 1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance? We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains. 🧵 www.biorxiv.org/content/10.1...
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- I know everyone's busy with all the political turmoil but just wanted to remind everyone that Russia invaded Ukraine exactly 3 years ago. This conflict lead to 400k and 800k killed/wounded Ukrainians and Russians (wiki). We must continue to aid UA to end this conflict on their terms more than ever!
- Use frozen Russian assets abroad to aid Ukraine!
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- Reposted by Aleksander SzczurekOnline Now: Identification of molecular determinants of gene-specific bursting patterns by high-throughput imaging screens
- Reposted by Aleksander SzczurekResearch @oxfordbiochemistry.bsky.social @ox.ac.uk supported by the Wellcome Trust (UK) and NIH (USA) reveals essential new player in the process of deciding whether genes should be made or not. Great work @jesskelley.bsky.social @robklose.bsky.social @edimitrova.bsky.social 👏 bit.ly/202502-klose
- Reposted by Aleksander SzczurekOur first deep dive into TEs and piRNAs in African cichlids is finally published! genomebiology.biomedcentral.com/articles/10.... rdcu.be/d69S5 Our main findings below 🧵 #TEsky
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- Reposted by Aleksander SzczurekMore than 40 percent of #postdocs leave academia. Those who landed a coveted faculty position were more likely to have had a highly cited paper, changed their research topic between their #PhD and postdoc, or moved abroad after receiving their doctorate. www.pnas.org/doi/10.1073/... @pnas.org
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- Have a look at important thread by Emilia's on why you should approach with caution non-callibrated genomics data ;)
- Reposted by Aleksander SzczurekFirst attempt in a (loosely defined) Single-Molecule Biophysics starter pack. Please share and (self-) nominate. go.bsky.app/CteFZM5at://did:plc:zra2wk7q33ld6p7xzrgyn6oa/app.bsky.graph.starterpack/3lasw2v4avf2l
