Guifeng Wei
RNA modifications, X-inactivation, epigenetics, bioinformatics
sites.google.com/view/guifengwei/
- Reposted by Guifeng WeiJust out @natrevimmunol.nature.com RNA-binding proteins and ribonucleoproteins as determinants of immunity www.nature.com/articles/s41... gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.
- an interesting work on how RNA regulatory elements control immune systems.
- Reposted by Guifeng WeiA new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration. www.nature.com/articles/s41...
- Reposted by Guifeng WeiI’m a fair-weather poster on here to say the least. However, I'm pleased to present our latest paper. A great effort from all authors and an interesting insight into transcriptional regulation (we think!). www.cell.com/molecular-ce...
- Reposted by Guifeng Wei⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation. 👉 We discover how sex and development signals are decoded at a single gene locus. www.nature.com/articles/s41... 👇 Bluetorial
- Thrilled to share our new Brockdorff lab paper at NSMB: we show that the primary role of m6A RNA modification on Xist is to promote RNA degradation. Xist turnover is mediated by the NEXT complex, not PAXT, and is independent of the m6A reader YTHDC1. www.nature.com/articles/s41...
- Reposted by Guifeng WeiToday, I would like to honor the memory of Roger Y. Tsien, who died on August 24, 2016. His legacy lives with all who use his technologies, including calcium sensors, fluorescent proteins, the acetoxymethyl (AM) ester, & many more! #FluorescenceFriday www.nature.com/articles/nme...
- Reposted by Guifeng WeiNew method drop: HCR-Proxy, a modular proximity labelling approach to profile local proteome composition around RNA at nanoscale, subcompartmental resolution. Thereby we resolved nested nucleolar layers and uncovered the grammar of spatial protein partitioning. www.biorxiv.org/content/10.1...
- Reposted by Guifeng WeiCheck out the latest study from our lab, led by Coffee Xiang (@coffeebond007.bsky.social) www.nature.com/articles/s41... (1/2)
- Reposted by Guifeng WeiVery happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...
- Fresh preprint by @flavia-con.bsky.social from our lab uncovers how SMCHD1 finds & binds chromatin using live-cell single-molecule imaging🔬 She reveals how SMCHD1 dynamically engages chromatin, including the inactive X chromosome, to maintain gene silencing. www.biorxiv.org/content/10.1...
- Reposted by Guifeng WeiExcited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come www.nature.com/articles/s41...
- Reposted by Guifeng WeiAn emotional day today @oxfordbiochemistry.bsky.social where leaders in the cell cycle field gathered to celebrate the life of Bela Novak and the huge impact he had on their work! www.bioch.ox.ac.uk/article/prof...
- Reposted by Guifeng WeiLong-range massively parallel reporter assay reveals rules of distal enhancer-promoter interactions www.biorxiv.org/content/10.1...
- I can’t believe this. He is so kind and friendly.
- Still hard to believe but Béla Novák died suddenly on Saturday. We've lost a fantastic colleague, mentor & great friend to many. There was really no-one else like him. Working with him was so much fun & I owe him a lot. All my thoughts are with his family. www.merton.ox.ac.uk/news/remembe...
- Reposted by Guifeng WeiPrime editing is precise and flexible, but it can require a lot of optimization. This post will give you some tips to get started making your prime edit as effective as possible! blog.addgene.org/des...
- Reposted by Guifeng WeiI am thrilled to share our latest work, released today 🤩 www-nature-com.insb.bib.cnrs.fr/articles/s41... It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.
- Preprint alert. Excited to share our latest work. We demonstrate that the primary function of m6A on Xist is to promote RNA degradation. www.biorxiv.org/content/10.1...
