Evgeny Kvon
Asst Prof at University of California, Irvine.
Genetics, Genomics, Gene Regulation, Development. Views are my own.
kvonlab.org
- Reposted by Evgeny KvonNew preprint from the lab! We identify the ZnF protein Mulberry as a condensation-dependent structural regulator of genome topology that organizes “multi-way regulatory hubs” in early Drosophila embryos. www.biorxiv.org/content/10.6...
- Reposted by Evgeny KvonNeil H. Shubin has been elected as the next NAS President! A leading evolutionary biologist and science communicator, Shubin will succeed Marcia McNutt on July 1. The Academy also named Cherry Murray as International Secretary and elected new councilors. Read more: www.nasonline.org/news/2026_pr...
- Reposted by Evgeny KvonJoin us this week for the next exciting VGZT session! 🎉 🗓️ Thursday, February 5th ⏰ 9:30 PST / 12:30 EST / 17:30 UTC / 17:30 GMT / 18:30 CET Our speakers are 👉 Evgeny Kvon (@evgenykvon.bsky.social) 👉 Silas Boye Nissen (on X: @SilasBoyeNissen) See you on Thursday! 👋
- Reposted by Evgeny Kvonexcellent thread
- I had intended to post something about this new Google DeepMind paper that appeared yesterday in Nature, but the press coverage has added to what there is to say. So this is a long 🧵 www.nature.com/articles/s41...
- Reposted by Evgeny KvonI had intended to post something about this new Google DeepMind paper that appeared yesterday in Nature, but the press coverage has added to what there is to say. So this is a long 🧵 www.nature.com/articles/s41...
- Reposted by Evgeny Kvon📣 I'm excited to share our latest preprint! We adapt and characterise a neurosphere-based CNCC differentiation protocol, and demonstrate utility for quantitative phenotyping and craniofacial disease modelling! 🧫 Read about Array-CNCC here: www.biorxiv.org/content/10.6... @uoe-igc.bsky.social
- Finally had a chance to read this beautiful paper from Susan Mackem's lab. It's interesting that even well-established paradigms, like Sonic Hedgehog's role as a traditional morphogen in limb development, can be proven wrong over time. www.sciencedirect.com/science/arti...
- Reposted by Evgeny KvonAnd it's out indeed! Huge congrats to @josanesousa.bsky.social, @gabrielalima19.bsky.social, @perezlouise.bsky.social & Hannah Schof! A true tour-de-force that highlights how emerging model systems can shed new light on long-standing macro-evolutionary questions. Go #axolotl, #polypterus #zebrafish!
- It’s out! 🐟 We compared three regeneration superstars—axolotl, zebrafish, and Polypterus—to ask how animals regrow limbs and fins. We find shared core processes, and other programs fine-tuned by evolution in surprising, lineage-specific ways. tinyurl.com/mpftkn7y
- Reposted by Evgeny KvonNow for the money... Overall, the budget is essentially flat. The biggest winner is NINDS with a 5.9% increase. The biggest losers are NIEHS and NIDDK. 4/5
- Reposted by Evgeny KvonI am still going through the materials, but it seems to be mostly good news. The language in the bill about indirect costs following the historical process seems very strong. 2/5
- Reposted by Evgeny KvonOur work on #RegulatoryTrajectories is out today in Nat. Comms: www.nature.com/articles/s41... Led by @raquelrouco.bsky.social, this study establishes a new framework to study how enhancer landscapes act sequentially at developmental loci and are silenced to shape gene expression patterns. (1/n)
- Reposted by Evgeny KvonGratitutde to all NIH study section participants who are participating in rescheduled meetings now and in January. Thank you for your service and thanks also to the hard working NIH staff who are making these happen. 🥰🧪
- Reposted by Evgeny KvonNow out: The new ENCODE registry of candidate cis-regulatory elements (🐭/👶) Major consortium effort, led by @moorejille.bsky.social - stay tuned for her "meme-torial" www.nature.com/articles/s41... @berkeleylab.lbl.gov @biosci.lbl.gov
- Reposted by Evgeny KvonFinally out! We studied the retinas of the longest-living vertebrate, the Greenland shark, and found that the retinas remain remarkably healthy in animals around 150 years old. What is the mechanism? It may be a highly efficient DNA repair system. Enjoy! www.nature.com/articles/s41...
- Reposted by Evgeny KvonI have always been fascinated by transcriptional activators that display intrinsic specificity towards some but not other promoter types as this implies alternative mechanisms! Hcfc1 directly bridges TFs to TFIID to overcome a CGI-specific rate-limiting step and activate CGI transcription. (2/2)
- Reposted by Evgeny KvonActivator-promoter compatibility in mammals - Hcfc1 is a key and intrinsically CGI-promoter-specific co-activator that cannot activate non-CGI promoters. Lead by @nemcko.bsky.social & Kevin Sabath in collab. with @plaschkalab.bsky.social @impvienna.bsky.social www.biorxiv.org/content/10.6... (1/2)
- Reposted by Evgeny KvonJoin @stirlingchurchman.bsky.social, @moffittlab.bsky.social, @saramostafavi.bsky.social, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at meetings.cshl.edu/meetings.asp...
- Not that long ago, in vivo mouse enhancer design was a dream. Today, it's a reality! Using transfer deep learning to design de novo synthetic embryonic enhancers active in the heart, limb, and CNS. Great collab with @alex-stark.bsky.social lab! @ucibiosci.bsky.social @impvienna.bsky.social
- Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)
- Reposted by Evgeny KvonOur preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)
- Reposted by Evgeny KvonI am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉! Our study reveals how cohesin guides focused and accurate homology search. Read more 👉 www.science.org/doi/10.1126/... Follow along for key insights and updates! 🧵
- Reposted by Evgeny KvonHere is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀 Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function now revised and journal accepted at www.science.org/doi/10.1126/... 🧵👇
- Reposted by Evgeny KvonRegister now for the EMBO Workshop "Limb development and regeneration: Quantitative, ecological, and diversification studies" in #Tokyo, Japan, 23–27 March 2026. Abstract submission/Registration deadline: 12/15 December 2025 meetings.embo.org/event/26-limb-dev #EMBOLimbDev #EMBOevents 🧪
- Reposted by Evgeny KvonI'm guest-editing a collection on "Enhancer-promoter interactions" at Genome Biology. Please send us your exciting stories! link.springer.com/collections/...
- Reposted by Evgeny KvonWe are pleased to announce a new preprint by @mlweilert.bsky.social: “Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs” (www.biorxiv.org/content/10.1...). See summary and longer recap below: (TLDR; low-affinity motifs matter as pioneers!)
- Reposted by Evgeny KvonOur new preprint is online! Viruses, bacteria and parasites use effector proteins to evade immunity and rewire host cell pathways. Together with @AlexanderStark8, we wondered if we could systematically map what these effectors, regardless of their origin, do in human cells. 1/8
- Reposted by Evgeny KvonMajor new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
- The Kvon lab won departmental Pumpkin Decorating Contest! Featuring a transgenic mouse with retinal enhancer driving GFP reporter. Mice have green fluorescent eyes. Spooky!
- Reposted by Evgeny Kvon📣 Paper alert! I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today! journals.biologists.com/dev/article/...
- Reposted by Evgeny KvonThe Kim Lab (sskimlab.org) at UC Irvine is recruiting motivated grad students interested in uncovering how transcriptional regulators direct cell fates. We accept students through the CMB (cmb.uci.edu) and MCSB (ccbs.uci.edu/education/mcsb/) PhD programs. Please share with prospective grad students!
- Reposted by Evgeny KvonWhich mutations rewire function of regulatory DNA? Excited to share SEAM: Systematic Explanation of Attribtuion-based Mechanisms. SEAM is an explainable AI method that dissects cis-regulatory mechanisms learned by seq2fun genomic deep learning models. Led by @EESetiz 1/N 🧵👇
- Reposted by Evgeny Kvon👀Next Wednesday, Oct 22nd, at #FragileNucleosome seminar, we are excited to host @alicelaigle.bsky.social and @seungsookim.bsky.social to tell us about amazing work they are doing! 🗓️Register here for upcoming session and the entire series: us06web.zoom.us/webinar/regi...
- Reposted by Evgeny KvonWhat is a promoter? And how does it work? We very happy to share our latest work trying to understand enhancer-promoter compatibility. I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters www.biorxiv.org/content/10.1...
- Reposted by Evgeny KvonThe #CSHA meeting on Systems Biology of Gene Regulation & Genome Editing kicks off next Monday! ⏳ Don’t miss your shot to dive into cutting-edge science. 👉 Check out the full program and register now on www.csh-asia.org?content/2767 Location: Suzhou. China | Oct.20-24, 2025
- Reposted by Evgeny KvonThe @crick.ac.uk is recruiting Early Career Group Leaders - Lab set-up, research costs, salaries for up to 5 researchers - Support for up to 12 years - Access to our core facilities - Competitive salary - Fantastic colleagues - All areas of biology Deadline 27 Nov www.crick.ac.uk/careers-stud...
- Reposted by Evgeny KvonIf you’re interested in exploring the relationship between chromatin organization and epigenetic memory using chromatin tracing microscopy, my group is recruiting a talented PhD student 🥳
- 🚨 Please share! We are seeking motivated PhD students who wish to work at the intersection of molecular life sciences and computational sciences. #IMPRS #IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de Check out our projects and apply by Jan 7th, 2026! www.molgen.mpg.de/IMPRSPhDproj...
- Reposted by Evgeny Kvon🧵1/ Excited to share our new paper introducing a new #singlecell assay: scTF-seq, a high-throughput single-cell approach to explore how transcription factor (TF) dose shapes cell identity and reprogramming outcomes. 🔗 www.nature.com/articles/s41... Big congrats to the entire team @EPFL & @SIAT_China
- Reposted by Evgeny KvonReally excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication. www.biorxiv.org/content/10.1... A🧵👇
- Reposted by Evgeny KvonAsking BlueSky for help: For a review, I am trying to accurately credit the first paper that measured pairwise 3D distances between 2 pieces of DNA on the same chromosome (or cosmid). Is Trask 1989 the first? I know of earlier single-locus papers (1982). www.sciencedirect.com/science/arti...
- Reposted by Evgeny KvonOut today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr
- Reposted by Evgeny KvonCongrats to Aurelie Hinterman aurhin.bsky.social, Chase Bolt chasebolt.bsky.social, and Brent Hawkins @homeobox.bsky.social! Coverage in NYTimes by @carlzimmer.com: www.nytimes.com/2025/09/17/s...
- Out today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr
- Reposted by Evgeny KvonMost neurodevelopmental disorders are caused by having 1 functional gene copy. Using SCN2A, we show that upregulating the functional copy rescues neuronal phenotypes. Amazing work with @neurobender.bsky.social led by Serena Tamura, Andrew Nelson, Perry Spratt & others. www.nature.com/articles/s41...
- Reposted by Evgeny KvonVery interesting new @wbickmor.bsky.social commentary on the mechanistic mystery that is very distal enhancer-promoter interactions www.nature.com/articles/s41...
- Reposted by Evgeny KvonJoin this year's CSH Asia Systems Biology of Gene Regulation & Genome Editing meeting in beautiful Suzhou, China, Oct 20-24. Let's bring the international communities together! Abstract deadline Sept 19! Infos and registration at csh-asia.org?content/2767. Please repost!
- Welcome Alex Stark @alex-stark.bsky.social to Bluesky!
- Reposted by Evgeny KvonBecome our colleague at @fmiscience.bsky.social! The FMI is a very special place to start your lab: a vibrant international institute with world-class research groups and facilities, core funding, fantastic trainees, great colleagues😅, and a collegial culture. Get in touch if you're interested!
- 🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬 Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
- Reposted by Evgeny KvonHonored to lead off such an amazing set of speakers 🧬 🌟
- We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social! register here for the entire series: us06web.zoom.us/webinar/regi...
- Join the Fragile Nucleosome Seminar featuring @gracebower.bsky.social, who will discuss our recent discovery of the Range Extender Element. (www.nature.com/articles/s41...)
- We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social! register here for the entire series: us06web.zoom.us/webinar/regi...
- Reposted by Evgeny Kvon1) I am delighted to present this terrific tour de force research conducted by my post-doc Dr. Gayani Senevirathne @gayani.bsky.social and published today in Nature - www.nature.com/articles/s41...
- Reposted by Evgeny KvonNew paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...
- Abstract deadline for CSH Asia meeting on Systems Biology of Gene Regulation and Genome Editing is extended to September 5th.
- Reposted by Evgeny KvonNew preprint with @gfudenberg.bsky.social We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding. This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇 www.biorxiv.org/content/10.1...
- Reposted by Evgeny Kvon🚨New preprint from the lab🚨 🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK. www.biorxiv.org/content/10.1...
- Reposted by Evgeny Kvon“Our findings suggest the existence of tens of thousands of enhancers that remain undiscovered by currently available chromatin data, underscoring the continued need for expanding resources for enhancer discovery.” Great paper and very important finding - many congrats Axel & team! 👏👏
- Enhancers are "just DNA" - finding all of them in the genome is hard. www.nature.com/articles/s41...
- Reposted by Evgeny KvonEnhancers are "just DNA" - finding all of them in the genome is hard. www.nature.com/articles/s41...
- Reposted by Evgeny KvonHiding in plain sight - how close are we to mapping ALL 🧬enhancers🧬 in the genome? Our new paper by Mannion et al. takes a systematic look at "hidden enhancers" and why they remain so hard to find. With @mosterwalder.bsky.social, @jlopezrios.bsky.social & many more www.nature.com/articles/s41...
