Marina Lusic
PI @ CIID, Heidelberg, and @DZIF. Mom of two and scientist in love with nuclear architecture - NPC- RNA processing, metabolic switches in infected immune blood and brain cells 🧬🔬🧬🦠🧫
- Reposted by Marina LusicI started offering career advice to two junior colleagues today in separate meetings, and both times I caught myself thinking that, if I'm honest, I don't have very good advice on navigating the current funding and job climate. I think it's important to say that no one does.
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- Reposted by Marina Lusic📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere. 🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
- Reposted by Marina LusicThis is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again. www.nature.com/immersive/d4...
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- Reposted by Marina Lusic1/ 🎄 We got our Christmas present today: "Two distinct chromatin modules regulate proinflammatory gene expression" is now published @natcellbio.nature.com doi.org/10.1038/s415.... Our study introduces a scATAC-seq-based framework for genome-wide analysis of gene regulation features.
- Exciting times ahead, indeed. Looking forward to 2026 and new inspiring and productive encounters, in Germany and Uk! !!!
- Reposted by Marina LusicI just published: ERC-Plus: jackpot science or missed chance to fix academia? My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re building. medium.com/p/erc-plus-j...
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- Reposted by Marina LusicHere is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀 Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function now revised and journal accepted at www.science.org/doi/10.1126/... 🧵👇
- Reposted by Marina LusicI am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉! Our study reveals how cohesin guides focused and accurate homology search. Read more 👉 www.science.org/doi/10.1126/... Follow along for key insights and updates! 🧵
- Reposted by Marina LusicNew paper out! How can we force HIV genomes out of their capsid shells and what can we learn about HIV biology doing so? Hint: capsid inhibitors actively re-route nuclear HIV complexes, and expose genomes via intriguing structural effects! open access: link.springer.com/article/10.1... read below
- Great new collaboration with @thmllr.bsky.social and Hans-Georg Kräusslich from @ciid-heidelberg.bsky.social came out on December 1st #HIV day - nuclear speckles & HIV capsid & antivirals gallore!!!
- Lab life and Christmas cookies can match when the students get creative
- Reposted by Marina LusicOur Spatial Genome Organisation 2025 attendees! Fantastic presentations, discussions & collaborations have taken place over the past 2 days, with plenty more to come. Its been a pleasure working with Karim, Irene & Matthias, looking forward to what the future holds for this brilliant series. #SGO25
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- Reposted by Marina LusicSometimes I think about how from 1935-1975ish, Bell Labs produced an insane amount of revolutionary science and technology, including 11 Nobel Prizes, the transistor, UNIX, C, the laser, the solar cell, information theory, etc. The secret? Provide scientists with ample, steady, no-strings funding.
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- Reposted by Marina LusicJUST IN: Jane Goodall, primatologist who transformed our understanding of the lives of apes, has died, according to an announcement from the Jane Goodall Institute.
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- www.nature.com/articles/d41... Do you think this is a matter of progress or concern?
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- Reposted by Marina Lusic@kazu_maeshima from the Genome Dynamics Laboratory at the National Institute of Genetics (@NIG_idenken) will present groundbreaking research on chromatin organization and behavior in live cells revealed by super-resolution imaging. nyulangone.zoom.us/webinar/regi... #chromatin2025
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- Reposted by Marina Lusic“Antiscience has gone beyond U.S. borders to Europe, Australia, and Africa. Defeating it will require unprecedented commitment and international cooperation, not only between scientific organizations, but also their host governments.” 🧪 #Disinformation #AntiScience time.com/7317436/scie...
- Reposted by Marina LusicLiquid-liquid phase separation of HP1? Not in our mouse fibroblasts… This paper by the Fabian Erdel group offers a fresh perspective on how this can be reconciled with seemingly conflicting reports: The phase separation propensity of HP1 decreases from yeast → fly → mouse. doi.org/10.1038/s414...
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- www.dzif.de/en/how-hiv-e... @dzif.bsky.social @dfg.de @natmicrobiol.nature.com #HIV #HIVScience #HIVCure #Nucleus #Nucleararchitecture #Splicing #R-loops #Genomeorganization
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- I love his comment on productive careers being unpredictable - and how he was never consciously directing himself anywhere, he was just following his nose www.science.org/content/arti...
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- Sad to hear about the passing of David Baltimore www.nytimes.com/2025/09/07/s...
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- Mind-blowing. "To our knowledge, females needing to clone members of another species have not previously been observed"
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- Reposted by Marina LusicOur new preprint 🧬🔗 www.biorxiv.org/content/10.1... BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via BRD4-mediated crosslinking— physical control of #chromatin by #LLPS transcription condensates. @semeigazin.bsky.social @katsuminami.bsky.social @masaashimazoe.bsky.social
- Reposted by Marina LusicIs euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing. www.biorxiv.org/cgi/content/...
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- Our work "Aquarius helicase facilitates HIV-1 integration into R-loop enriched genomic regions" is out @natmicrobiol.nature.com, showing HIV-1 integration into R-loop genomic regions upon their resolution by cellular splicing helicase Aquarius (AQR) of the Intron Binding Complex (IBC)🧵.
- Our study, conducted in primary human CD4+ T cells, shows that HIV-1 preferentially integrates into intronic regions of transcriptionally active genes, where RNA:DNA hybrids (R-loops) are often created.
- Very happy to have contributed to this exiting story on nuclear softening caused by metabolic switch caused by oncometabolite 2-HG causing whitening of the brown adipocytes Trifunovic lab CECAD Cologne softeninghttps://www.nature.com/articles/s42255-025-01332-8?utm_source=dlvr.it&utm_medium=twitter
- Reposted by Marina LusicCheck out this exciting meeting and register! Fantastic line-up of speakers on cell biology of the nucleus and a great venue 🔥
- 📢 Abstract submission deadline reminder for 'Cell biology of the nucleus'! Before packing your bags and leaving for your summer vacation, there is one important task left to do: submit your abstract for #EESNucleus ✍️ Deadline is 26 August: s.embl.org/ees25-07-bl
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- With boost to NIH budget, Senate panel rejects Trump’s plan to slash agency | Science | AAAS www.science.org/content/arti...
- Reposted by Marina LusicMany proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...
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- Reposted by Marina LusicHow do enhancer-gene contacts relate to transcription activation? In mouse embryonic stem cells, a combo of STED, oligoFISH & RNA FISH shows that 3% of Dppa3 alleles transcribe. For these, enhancers and promoters come closer (panel E). Stumberger ... Leonhardt & Harz www.biorxiv.org/content/10.1...
- Reposted by Marina LusicReminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪 www.richmondscientific.com/how-a-discov...
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- Reposted by Marina LusicDie #Exzellenzcluster stehen fest: Heute hat die Exzellenzkommission 70 Projekte zur Förderung ausgewählt. 45 Cluster werden fortgesetzt, 25 neu eingerichtet. Die Förderung beginnt ab 1. Jan. 2026 für 7 Jahre, die Fördersumme beträgt insg. 539 Mio. €/Jahr. Die Liste: www.dfg.de/resource/blo... 1/3
- Reposted by Marina LusicDeaths from heart disease down 75%, that’s NIH. Deaths from stroke down 75%, that’s NIH. HIV/AIDS no longer a death sentence, that’s NIH. 99% of FDA approved drugs in the last decade, that’s NIH. Please show this video to anyone who doesn’t understand why the NIH is so important.
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- Great work on 3D chromatin from @becklab.bsky.social led by @jpkreysing.bsky.social and @sergiocruzleon.bsky.social in primary human resting CD4 T cells! Very happy to have contributed !
- New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
- An excellent view of the current state of the affairs in US science by Paul Bieniasz www.theguardian.com/commentisfre...
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