Marina Lusic
PI @ CIID, Heidelberg, and @DZIF. Mom of two and scientist in love with nuclear architecture - NPC- RNA processing, metabolic switches in infected immune blood and brain cells 🧬🔬🧬🦠🧫
- 1/ 🎄 We got our Christmas present today: "Two distinct chromatin modules regulate proinflammatory gene expression" is now published @natcellbio.nature.com doi.org/10.1038/s415.... Our study introduces a scATAC-seq-based framework for genome-wide analysis of gene regulation features.
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View full thread6/ 🎯 Our AC/DC framework reveals how cells achieve precise gene control. TRGs with TF promoter binding show fastest induction. DCs enable coordinated burst-size increases, while ACs allow fine-tuned gene-specific regulation—working together to support complex programs.
- Was the AC/DC intentional or s pure coincidence😀congrats, definitely a great present🥳
- Exciting times ahead, indeed. Looking forward to 2026 and new inspiring and productive encounters, in Germany and Uk! !!!
- Really excited to be awarded a British council UK-Germany Springboard grant! Exciting times ahead as a UK cohort featuring the labs of myself and Ines Castro and @jollylab.bsky.social will launch trips and research meetings to build a collaboration with @marinalusic.bsky.social in CIID Heidelberg.
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- Omg, is it a lynx?
- Great new collaboration with @thmllr.bsky.social and Hans-Georg Kräusslich from @ciid-heidelberg.bsky.social came out on December 1st #HIV day - nuclear speckles & HIV capsid & antivirals gallore!!!
- If you’re interested in HIV capsids, nuclear speckles, or capsid-targeting antivirals, we’d love for you to check it out and share! 🙌 link.springer.com/article/10.1...
- Lab life and Christmas cookies can match when the students get creative
- www.nature.com/articles/d41... Do you think this is a matter of progress or concern?
- www.dzif.de/en/how-hiv-e... @dzif.bsky.social @dfg.de @natmicrobiol.nature.com #HIV #HIVScience #HIVCure #Nucleus #Nucleararchitecture #Splicing #R-loops #Genomeorganization
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- Stellar!!!
- I love his comment on productive careers being unpredictable - and how he was never consciously directing himself anywhere, he was just following his nose www.science.org/content/arti...
- 🎵WHY DO ENHANCER! SUDDENLY APPEAR! EVERY TIME! THEY ARE NEAR!?! JUST LIKE ME! THEY LONG TO BE! CLOSE TO POLII! 🎵 www.nature.com/articles/s41...
- Ahaha that is great!! Love it and will sing this forever!!!!
- Sad to hear about the passing of David Baltimore www.nytimes.com/2025/09/07/s...
- Mind-blowing. "To our knowledge, females needing to clone members of another species have not previously been observed"
- Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
- Belated congrats Abby! Great to see this inspiring story in the final published form!
- Our work "Aquarius helicase facilitates HIV-1 integration into R-loop enriched genomic regions" is out @natmicrobiol.nature.com, showing HIV-1 integration into R-loop genomic regions upon their resolution by cellular splicing helicase Aquarius (AQR) of the Intron Binding Complex (IBC)🧵.
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View full threadOur discovery offers a critical new angle for HIV intervention. By interfering with the host mechanisms that support targeted integration, we hope to affect viral persistence without the need for lifelong daily treatment.
- RNA helicase Aquarius (AQR), a component of the Intron Binding Complex (IBC), is an essential host factor for R-loop integration, as it unwinds R-loops and interacts with integrase to facilitate precise targeting of the viral genome.
- AQR knock out in primary T cells hampers integration efficiency and shifts remaining integration to intergenic and R-loop–depleted regions, demonstrating that R-loop-rich sites are preferred by HIV-1 and are facilitated by host RNA metabolism.
- Our study, conducted in primary human CD4+ T cells, shows that HIV-1 preferentially integrates into intronic regions of transcriptionally active genes, where RNA:DNA hybrids (R-loops) are often created.
- We demonstrate that HIV-1 integrase binds directly to R-loops, suggesting that the RNA component of chromatin acts as a guiding signal — effectively a molecular “bait” — for integration.
- Very happy to have contributed to this exiting story on nuclear softening caused by metabolic switch caused by oncometabolite 2-HG causing whitening of the brown adipocytes Trifunovic lab CECAD Cologne softeninghttps://www.nature.com/articles/s42255-025-01332-8?utm_source=dlvr.it&utm_medium=twitter
- With boost to NIH budget, Senate panel rejects Trump’s plan to slash agency | Science | AAAS www.science.org/content/arti...
- Great work on 3D chromatin from @becklab.bsky.social led by @jpkreysing.bsky.social and @sergiocruzleon.bsky.social in primary human resting CD4 T cells! Very happy to have contributed !
- New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
- An excellent view of the current state of the affairs in US science by Paul Bieniasz www.theguardian.com/commentisfre...
- This is one of the first coverages about the peaceful students protests in Serbia, which converged yesterday in the city of Novi Sad, where three months ago a concrete canopy of the newly inaugurated railway station collapsed to kill 15 people www.theguardian.com/world/video/...
- Taking responsibility: Asilomar and its legacy | Science www.science.org/doi/10.1126/...
- This will have a very tragic impact
- Some months ago, I received the great news that my #NIH RO1 grant received a likely fundable score. With the NIH not being able to hold meetings and take decision, I found out that the council meeting is canceled (it was planned next week). 🧵/1
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- I'm so sorry to hear that, Steeve. I'm also sorry to miss you during your visit to HD in March 😔, I will not be here the entire week.
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- Good to know we have the same folder! I place mine in the next year - the Russian doll 🪆 principle!
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- Black is barely visible in the composite. What are your color alternatives? Very nice indeed!
- Delighted to publish my new molecular animation: DNA Break Repair by Homologous Recombination youtu.be/Xe-83tBcxhs
- How cool is this? How many hourse of work behind a 3:44 movie? Congratulations!!!!
- Enchanting! I could watch this over and over again!
- Delighted to publish my new molecular animation: DNA Break Repair by Homologous Recombination youtu.be/Xe-83tBcxhs
- Resolution enhancement by sequential imaging (RESI) improves the resolution of fluorescent microscopy down to Å scale and resolves single Nuclear Pore Complex proteins! Smash hit!
- 1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
- Monocytes seem to be the key! So exciting, congratulations to all!
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[Not loaded yet]- Maybe @xrnchew.bsky.social can help!
- How to get started on academic 🦋https://blogs.lse.ac.uk/impactofsocialsciences/2024/11/18/how-to-get-started-with-academic-bluesky/
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- Looking forward to hearing your lectures in Heidelberg!
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- Bravo Akis!!!
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- So sweet! Congratulations!
- Amazing work!
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- Sylvia, you have the sunshine inside!!!!
- So true - so hard to find your right place (University or Department) and your reviewers. Own experience.
- Our paper on a centromere-enriched retroelement is out! link.springer.com/article/10.1... Congratulations to all the authors! Comments and reposts welcome and appreciated 🧬🔬
- Sounds very interesting - looking forward to reading it!
- A starter pack for all virologists out there on the blue side ! Might be missing some people but it’s a good start ! go.bsky.app/DmphBCTat://did:plc:qyclmerxxlqtz6a2rotf5ehk/app.bsky.graph.starterpack/3lb55p4xhxw2m
- Could you please add me?
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- Can you please add me here?
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- 7 years ago, I met a junior fellow named Jason Buenrostro who blew me away with a vision of futuristic genomic technologies Today, we (Ajay Labade, Caroline Comenho) are excited to share our first steps into that future: Expansion in situ genome sequencing 1/
- This is stunning!!!
