Karim Majzoub
Group leader @igmm-montpel.bsky.social studying viruses - ERC Stg- Amateur athlete and musician- Husband and father- Europtimist @biolum-montpellier.bsky.social
igmm.cnrs.fr/en/team/rna-viruses…
- STING and PiPs !
- Reposted by Karim MajzoubAll you want for christmas is.... transposon mutagenesis! Our new work at @cultivarium.bsky.social screening lots of transposon vectors in lots of bacteria, from @charliegilbert.bsky.social and team. Transposon and promoter modular parts available on Addgene (pooled library will be there soon too)
- A scalable transposon mutagenesis system for non-model bacteria biorxiv.org/content/10.64898/20…
- Reposted by Karim MajzoubScience update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
- Endogenous retroviruses, RNA and human development !
- Zoe Denis a PhD student in our lab , describing the first marsupial deltavirus ! :)
- TimeVaults record cellular transcriptomes
- Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis
- Kudos @jbdsf.bsky.social and team for this beautiful work !
- Very interesting interview
- pTOS is the new glp1?
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- Reposted by Karim MajzoubHmmm ... sperm RNAs? Paternal effects? It's like an early Christmas present! Very nice article by Ivan Amato, including quotes and work from some excellent scientists like @colinconine.bsky.social ... and me, as well. ;) www.quantamagazine.org/how-dads-fit...
- Reposted by Karim Majzoub“The math is brutal and the juxtaposition stark: millions for OpenAI while pink slips go out to longtime lecturers. The CSU isn’t investing in education—it’s outsourcing it, paying premium prices for a chatbot many students were already using for free.“ www.currentaffairs.org/news/ai-is-d...
- Really neat and elegant Virology by @samjwilsonphd.bsky.social and team ! Watch out for these avian PB1 pol subunits ! Congrats to all co-authors ! @science.org
- How does fever work? Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence. This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵 www.science.org/doi/10.1126/...
- Really neat and elegant Virology by @samjwilsonphd.bsky.social and team ! Watch out for these avian PB1 pol subunits ! Congrats to all co-authors ! @science.org
- Reposted by Karim Majzoub🧬🛡️How are new immune mechanisms created? We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org. 👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors! doi.org/10.1073/pnas...
- My lab is recruiting a post-doc ! please share ! emploi.cnrs.fr/Offres/CDD/U...
- Bravo @mkrupovic.bsky.social and team !
- P-bodies , microRNAs and cell fate ! Not everything is transcription in cell fate decisions ;)
- Reposted by Karim MajzoubLab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
- Reposted by Karim MajzoubJust out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
- Shout out for @johanneszuber.bsky.social and team ! Beautiful work with new biology !
- Reposted by Karim MajzoubHere's the link to the system, try it! qedscience.com @qedscience.bsky.social
- Reposted by Karim Majzoub@viroscope.bsky.social (@karimaj.bsky.social team) partage dans The Scientist ses travaux sur les deltavirus et l’imagerie de cellules, des cellules humaines aux cellules de boa constrictor 🐍. 👉 Lire l’article : “Boa Constrictor Brain Cells Slither into Focus” www.the-scientist.com/boa-constric...
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- Great crowd and attendance for our France-Japan Virology workshop we kicked off this morning !
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- Meet us in 2 days in Montpellier for the French-Japan Virology symposium!
- Meet us at Genopolys , Montpellier for a France-Japan virology workshop ! 9-10 october 2025 ! 2 exciting days with many viruses! Co-organized with @systemsvirology.bsky.social Kei Sato and Monsef Benkirane @igmm-montpel.bsky.social @cnrsbiologie.bsky.social @umontpellier.bsky.social
- Reposted by Karim MajzoubLead by postdoc in the lab Ruiqi Ge and in collaboration with Bob Coffey’s lab, we are happy to share rPAL-seq for rapid and sensitive sequencing based profiling of glycoRNAs @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
- New paper (micro) from our lab : “No evidence for human or rodent deltavirus replication in yeast”. A collaboration with Dom helmlinger’s lab .
- Our @viroscope.bsky.social Joe McKellar interviewed by The-Scientist Magazine ! Look at all these beautiful cells we have in the lab :)
- Reposted by Karim Majzoub🧬 𝐋’𝐚𝐫𝐭 𝐝𝐞́𝐥𝐢𝐜𝐚𝐭 𝐝𝐞 𝐟𝐚𝐢𝐫𝐞 𝐭𝐚𝐢𝐫𝐞 𝐥𝐞𝐬 𝐠𝐞̀𝐧𝐞𝐬 Des scientifiques de l'IGMM utilisent l’embryon de drosophile pour démontrer que la répression de l’expression des gènes est un mécanisme beaucoup plus complexe qu’attendu. 📖 👉 lnkd.in/dPqUREuf 📷 © Mounia Lagha et Virginia Pimmett
- Reposted by Karim MajzoubNaiavirus: an enveloped giant virus with a pleomorphic, flexible tail nature.com/articles/s41467-025-63463-6
- Meet us at Genopolys , Montpellier for a France-Japan virology workshop ! 9-10 october 2025 ! 2 exciting days with many viruses! Co-organized with @systemsvirology.bsky.social Kei Sato and Monsef Benkirane @igmm-montpel.bsky.social @cnrsbiologie.bsky.social @umontpellier.bsky.social
- Registration link : www.eventbrite.com/e/billets-st...
- Reposted by Karim Majzoubhey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!
- Endogenous Deltaviruses (EVEs) in termite genomes !
- RIP
- A giant in molecular biology and virology has passed. RIP David Baltimore. www.nytimes.com/2025/09/07/s...
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- Reposted by Karim MajzoubNew pre-print from Doudna lab members @erinedoherty.bsky.social & @jnoms.bsky.social ✨ Here we explore how recurrent adaptation of a single anti-defense protein fold enables evasion of distinct immune systems.
- Excited to share our new preprint co-led by @jnoms.bsky.social! Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.
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- Incredible discovery ! The first known role for sugar coated RNAs : immune evasion ! @raflynn5.bsky.social does it angain with @vinnieviruses.bsky.social @vijayrathinam.bsky.social and colleagues !
- RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
- Reposted by Karim MajzoubRNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
- Proud of Roni , a PhD student from our lab !
- Félicitations à Roni Sleiman ! Médaille d’argent à la Journée Infectiopole Sud 2025 pour sa présentation : “Unraveling Deltavirus Nuclear Exit and Assembly”. 🎉 Prix de 500 €, remis à l’IHU Méditerranée, Marseille. @karimaj.bsky.social
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A must-read for histone afficionados: our new review on 'Histone-mediated chromatin organization in prokaryotes and viruses' www.cell.com/trends/bioch... @samuelschwab.bsky.social @vikramalva.bsky.social - Reposted by Karim Majzoub[Not loaded yet]
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- Reposted by Karim MajzoubGlad to see this paper finally out! An episodic burst of massive genomic rearrangements and the origin of non-marine annelids @natecoevo.nature.com @ibe-barcelona.bsky.social @csic.es @erc.europa.eu www.nature.com/articles/s41...
- RNase L Produces tRNA-derived RNAs that Contribute to Translation Inhibition
- Reposted by Karim Majzoub🧬 Les obélisques, nouvelles molécules d’ARN circulaires, intriguent les chercheurs. @karimaj.bsky.social en parle dans @france3occitanie.bsky.social & @GEO_fr 👇 🔗 france3-regions.franceinfo.fr/occitanie/he... 🔗 www.geo.fr/sciences/les...
- Reposted by Karim MajzoubWe are enthusiastic about welcoming new group leader colleagues who share our core values of collegiality, interdisciplinarity and scientific excellence. www.igmm.cnrs.fr Apply and Join us!
- Reposted by Karim MajzoubOpenings are suited for junior and established group leaders, and for early-career scientists who wish to start their research group.
- Reposted by Karim Majzoub📣 We are recruiting new group leaders in Innovative Biology! RNA biology Epigenetic regulation Cell cycle regulation Cancer, immunology Virology Application and information ⬇️ application.igmm.cnrs.fr @cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social
- I was also a J1 visa holder once (actually 3 times)
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- Protein sequencing on desktop sequencer maybe possible soon ?! 🤯🤯
- Reposted by Karim Majzoub1/10 Today in @science.org in collaboration with the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...
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- With Joe in our lab, we discovered a new mode of how some viral sattelites can spread : A form of viral hitchhiking we termed Viral Trojan Horse ! check our paper on biorXiv : www.biorxiv.org/content/10.1...
- Reposted by Karim MajzoubEU augments opportunities for scientists around the world to launch or re-launch their careers in Europe.
- Europe’s choice is clear. To put science at the heart of its economy. To become the home of scientific freedom and collaboration. And to welcome talent from all over the world. I’m glad to present the first elements of our Choose Europe Initiative. → europa.eu/!TTbWbJ
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- Reposted by Karim MajzoubExcited to see this out in @science.org today!! www.science.org/doi/10.1126/...
- Reposted by Karim Majzoub💥🥳 At long last, our latest paper is out! Gag proteins of endogenous retroviruses are required for zebrafish development www.pnas.org/doi/10.1073/... Led heroically by Sylvia Chang & @jonowells.bsky.social A study which has changed the way I think of #transposons! No less! 🧵 1/n
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- #ECV #ECV2025 very proud of @viroscope.bsky.social that presented brilliantly his work in our lab “Deltaviruses spread through viral Trojan Horse” at the European Congress of Virology 2025 in Cavtat, Croatia !
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- Isothhermal Ago- PCR !
- Nice , but what about RNA viruses with no RdRp ? ;) yes , they exist .
- Reposted by Karim MajzoubRead preprints. Cite preprints. Email people and tell them you loved their preprint. Email people you hated their preprint. Embrace preprints, preprints are good.
- Another poxviral piracy !
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- Reposted by Karim MajzoubThe field of bacterial immunity is incredibly vibrant with many novel discoveries and fantastic new biology. Here is a nice summary of some of the work done recently! www.nature.com/articles/d41...
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- Reposted by Karim MajzoubAfter 8 months of peer review, our manuscript was published today @nature.com showing that bovine H5N1 viruses bind poorly to human-type sialic acid receptors. We now know that the virus is only 1 HA substitution away from efficiently binding human receptors. www.nature.com/articles/s41...
- Reposted by Karim MajzoubRecombination between positive-sense and negative-sense RNA viruses: journals.plos.org/plospathogen...
- Beautiful paper
