Vijay Rathinam
Professor of Immunology, UConn Health School of Medicine.
Studying innate immunity, infection and inflammation.
facultydirectory.uchc.edu/profile?profileId=R…
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- Reposted by Vijay RathinamNew #glycotime discovery from @raflynn5.bsky.social’s lab @bostonchildrens.bsky.social @harvard.edu, cell surface glycoRNA-RBP complexes organized by heparan sulfate PG nanoclusters that modulate VEGF signaling www.nature.com/articles/s41...
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- A new function for GlycoRNAs!! The GlycoRNA-Heparan sulfate complex on the cell surface controls VEGF-A signaling and angiogenesis. Superexciting findings from Ryan Flynn's lab. Congratulations to all authors!! @raflynn5.bsky.social www.nature.com/articles/s41...
- Reposted by Vijay RathinamThrilled to share our new preprint showing that dietary amino acids license the NLRP3 inflammasome via mTOR-dependent mRNA translation! Congrats to co-1st authors @mikelhaggadone.bsky.social, Brian Goldspiel, co-senior author @metabailism.bsky.social & collaborators! www.biorxiv.org/content/10.6...
- I’m stoked to share my postdoc work with @sunnyshinlab.bsky.social, a collaborative effort with @metabailism.bsky.social & Brian Goldspiel, aided by many valued collaborators: Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly. Some big takeaways:
- Shiga toxin-induced human cell death—the underlying cause of potentially lethal renal disease in children—occurs via pyroptosis, not apoptosis as previously thought, and is driven by an intriguing NLRP1–>Caspase-8–>Caspase-3–>gasdermin E pathway. Congrats to Priya's lab! @kailasanvanaja.bsky.social
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- Reposted by Vijay Rathinam💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...
- Structural features underlying LPS recognition by caspase-11/4 and the activation of the noncanonical inflammasome. Congrats to Chengliang Wang & Jianbin Ruan @uconnhealth.bsky.social Happy to contribute to this exciting paper! www.science.org/doi/10.1126/...
- Reposted by Vijay RathinamPleased to share our review l. Thank you @payalyokota.bsky.social
- Happy Friday! We're so thrilled to share our review on #trainedimmunity out in @elife.bsky.social today. We had a great time writing this. Honored to be included in the special issue of trained immunity. Always an absolute treat to write with @khannakm.bsky.social elifesciences.org/articles/108...
- Reposted by Vijay Rathinam#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇
- Reposted by Vijay RathinamNew story from the lab by PhD student Seb Grant. Started as a summer project and developed into an interesting story. www.biorxiv.org/content/10.1...
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- Reposted by Vijay Rathinam🚨Thrilled to share our latest work, published online today @nature.com in which we decipher mechanisms underlying the enigmatic VEXAS syndrome - a huge team effort @mskcancercenter.bsky.social led by superstars Varun Narendra + @tandriladas.bsky.social 1/ www.nature.com/articles/s41...
- Reposted by Vijay RathinamCheck out our latest work led by two talented postdocs, Madhura @mkulkarni.bsky.social and Chris. We find that CASP4/5 can cleave and activate CASP3/7, acting as initiators of both pyroptosis and apoptosis. Notably, both are needed for full pathogen defense! www.biorxiv.org/content/10.1...
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- Thanks to Autoimmunity podcast @kevinbonham.bsky.social & @woodrufflab.bsky.social for discussing our glycoRNA paper w/ @raflynn5.bsky.social @vinnieviruses.bsky.social
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- Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation: Molecular Cell www.cell.com/molecular-ce... @raflynn5.bsky.social @vinnieviruses.bsky.social
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- Reposted by Vijay RathinamExcited to share our new publication, out today in Nature! www.nature.com/articles/s41.... @kanchanj.bsky.social led this fascinating fungal-bacterial interaction project. We are grateful for our wonderful collaborators Brian Peters and David Underhill.
- Reposted by Vijay RathinamSo excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.
- #NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/... #Inflammasome
- Reposted by Vijay Rathinam#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
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- today.uconn.edu/2025/08/swee... Thanks to @uconnresearch.bsky.social and @kimkrieger.bsky.social for covering our glycoRNA paper @vinnieviruses.bsky.social @raflynn5.bsky.social
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- Reposted by Vijay RathinamRNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
- Why does RNA undergo glycosylation? Excited to have our paper out. We in collab w/ Ryan Flynn @raflynn5.bsky.social show N-glycans on glycoRNA hide self-RNA from endosomal TLRs promoting silent removal of dead cells. www.nature.com/articles/s41... @uconnresearch.bsky.social @uconnhealth.bsky.social
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- Reposted by Vijay Rathinam#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!
- We are excited to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network. www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
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- Reposted by Vijay RathinamHow can a Salmonella effector change the specificity of a host kinase? SteE mediates kinase reprogramming via mimicry of conserved eukaryotic-like motifs- doi.org/10.1038/s443... Great collaboration with @katrinrittinger.bsky.social + big thanks to all authors & congrats to lead PDRA Ioanna Panagi!
- Inflammasome signaling in astrocytes modulates hippocampal plasticity! Exciting finding from @lukensjohnr.bsky.social lab! www.cell.com/immunity/ful...
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- Type I interferon signaling in Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis. Congratulations on this cool story to @khannakm.bsky.social @payalyokota.bsky.social @yeungadventures.bsky.social www.cell.com/immunity/ful...
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