ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ
Physician-scientist at UC San Diego, Microbiology, Immunology, Novel Drug and Vaccine Discovery, #IDSky, Mentoring and Supporting STEM Career Development.
Enjoy exploring the outdoors, world cultures, sports, comedy, community.
http://nizetlab.ucsd.edu
- Visiting NY Academy of Sciences
- February 1st (dead of winter) #UCSanDiego #Blimp #75°F
- The Royal Swedish Academy of Sciences said it was awarding Ramanathan the Crafoord Prize in Geosciences for his groundbreaking work that has “laid the foundation for our understanding of how small particles and gases that accumulate in the atmosphere contribute to climate change.”
- "Bear" (2005) Tim Hawkinson Eight granite boulders 23.5 feet high 185 tons (370,000 pounds) UC San Diego Campus Stuart Collection
- Reposted by ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪYesterday it was cows using tools, today its penguins using satellite imagery.
- Reposted by ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪWe're going to randomise patients in SNAP to: 1) clopidogrel vs no clopidogrel (CLOPIDO SNAP #1) and; 2) aspirin vs clopidogrel for those already on aspirin (CLOPIDO SNAP #2).
- Pleased to share our brief commentary on how antiplatelet drugs such as ticagrelor (Brilinta) may have an intriguing beneficial action toward effective treatment of Staphylococcus aureus bacteremia and endovascular infection #drugrepurposing
- An earlier article we contributed on the underlying mechanisms www.science.org/doi/10.1126/...
- a "Bed of Nails" to combat antibiotic-resistant pathogens "NANOPILLARS" are the novel anti-biofilm strategy Bioengineering of materials (e.g. catheters) to mimic structures naturally found on the wings of cicadas that mechanically pierce and kill Pseudomonas aeruginosa
- This is some crazy stuff—roughly 1.5 miles in 54 degree water and strong currents Famously, no human has been officially confirmed to have successfully escaped Alcatraz From the video (link below) looks like the #coyote may have regrets about the adventure Animals—especially canines—are amazing
- 𝗜𝗠𝗣𝗢𝗥𝗧𝗔𝗡𝗧 𝗧𝗢 𝗞𝗡𝗢𝗪 Comprehensive analysis confirms safety of TYLENOL 💊 in pregnancy 𝘊𝘶𝘳𝘳𝘦𝘯𝘵 𝘦𝘷𝘪𝘥𝘦𝘯𝘤𝘦 𝘥𝘰𝘦𝘴 𝘯𝘰𝘵 𝘪𝘯𝘥𝘪𝘤𝘢𝘵𝘦 𝘢 𝘤𝘭𝘪𝘯𝘪𝘤𝘢𝘭𝘭𝘺 𝘪𝘮𝘱𝘰𝘳𝘵𝘢𝘯𝘵 𝘪𝘯𝘤𝘳𝘦𝘢𝘴𝘦 𝘪𝘯 𝘵𝘩𝘦 𝘭𝘪𝘬𝘦𝘭𝘪𝘩𝘰𝘰𝘥 𝘰𝘧 𝘢𝘶𝘵𝘪𝘴𝘮 𝘴𝘱𝘦𝘤𝘵𝘳𝘶𝘮 𝘥𝘪𝘴𝘰𝘳𝘥𝘦𝘳, 𝘈𝘋𝘏𝘋, 𝘰𝘳 𝘪𝘯𝘵𝘦𝘭𝘭𝘦𝘤𝘵𝘶𝘢𝘭 𝘥𝘪𝘴𝘢𝘣𝘪𝘭𝘪𝘵𝘺 𝘪𝘯 𝘤𝘩𝘪𝘭𝘥𝘳𝘦𝘯 𝘰𝘧 𝘱𝘳𝘦𝘨𝘯𝘢𝘯𝘵 𝘪𝘯𝘥𝘪𝘷𝘪𝘥𝘶𝘢𝘭𝘴 𝘸𝘩𝘰 𝘶𝘴𝘦 𝘱𝘢𝘳𝘢𝘤𝘦𝘵𝘢𝘮𝘰𝘭 𝘢𝘴 𝘥𝘪𝘳𝘦𝘤𝘵𝘦𝘥
- Ensuring high quality mentorship and career development opportunities for our junior faculty and postdoctoral fellows are a big focus of our Health Sciences Office of Faculty Affairs (OFA), Altman Clinical and Translational Research Institute (ACTRI), and Faculty Mentor Training Programs (FMTP).
- From first hand clinical experience, meningococcal sepsis and meningitis are indelibly etched in my mind—diseases that can progress rapidly from flu-like symptoms to loss of life or limb—even in previously health children & young adults Vaccination had reduced rates up to 90% – don't give up now
- New Year's 2026 Party and this year's Lab T-Shirt
- The Da Vinci Code
- I thought today's bright pre-dawn San Diego moon might bring out the coyotes ...
- This paper has everything I could wish for in a scientific insight! Puppy ➡️ Strep ➡️ Happiness Dog ownership in adolescents was associated with fewer social problems and altered gut microbiota. Notably, a Streptococcus ASV correlated with sociability in both adolescents and ex-germ-free mice.
- Clever idea! Nasal spray using lipid nanoparticles that delivers molecular instructions to flu-infected respiratory cells in a 2-stage process: (a) an mRNA instructs cells to make Cas13, followed by (b) a guide RNA directing Cas13 to a specific region of the influenza virus RNA to inactivate it
- Vaccines are a key aspect of healthy aging. I'm keeping up to date to protect me, my family, and friends from specific pathogens (RSV, Shingles, Flu, Pneumococcus). Added benefits of reduced risk of dementia, heart attacks, and stroke, along with longer overall health span are icing on the cake!
- ANTALYTICAL THINKING A 2024 study in PNAS found that ants outperform humans at tests of collective intelligence. C'mon people, we need to step it up www.pnas.org/doi/10.1073/...
- Masterstroke
- IDSA has selected Jeanne Marrazzo, MD, MPH, FIDSA, as its next chief executive officer, effective Jan. 12, 2026. Learn more: bit.ly/4pHt2nF
- Great work from the team of Carole Peyssonnaux at the Institut Cochin in Paris Hepcidin directly lowers systemic iron levels in the gut lumen by suppressing enterocyte DMT1 This study shows a previously unrecognized, therapeutically exploitable role for extrahepatic hepcidin in iron homeostasis
- One to watch: @marvicct.bsky.social
- Wonderful work from the lab of Brad Moore at UC San Diego: cloning and harnessing the versatile octopus camouflage pigment xanthommatin for diverse real world applications — cool TV news story here and a link to Nature Biotech manuscript below @scrippsocean.bsky.social @ucsdpharmacy.bsky.social
- Superb work from labs of Elizabeth Campbell + Jeremy Rock @rockefeller.edu Nat Micro By targeting distinct, functionally vulnerable steps of the transcription cycle, AAP-SO2 overcomes rifampicin resistance, suppresses resistance evolution, and synergistically enhances clearance of drug-tolerant Mtb
- Reposted by ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪThe kind .. you find … in a second hand store
- tragic chain of events #IDSKY rabies is an extremely dangerous viral CNS disease transmitted via infected saliva (usually bites) and almost always fatal once symptoms start fortunately, it is entirely preventable with prompt medical care (vaccines and immune globulin) after potential exposure
- Congratulations to DOCTOR Concepcion Sanchez, PhD on the successful defense of her thesis in the Biomedical Science Graduate Program in the laboratory of Associate Professor David Gonzalez Top notch proteomics with mechanistic follow through and a bright career ahead
- a festive atmosphere for our Annual Holiday White Elephant Gift and Cookie Exchange thanks to new postdoctoral scholar Consuelo Sauceda for taking the leadership reins
- Sharing this because I know some of you live your lives with no egrets #dawnpatrol #sandiego #pacifichighlandsranch
- Important and timely read in the New England Journal of Medicine: Twelve former commissioners of the FDA express concern that the agency’s recent moves will undermine a regulatory model designed to ensure vaccine safety, effectiveness, and availability.
- Going away celebration for postdoc Sydney Morrill PhD, completing her work in the lab on nanovaccines for N. gonorrhoeae and Candida—off to our nation’s capital to begin her Assoc. of Public Health Laboratories (APHL) fellowship—a step on her way to her long term career interests in Science Policy.
- Very cool @JACS Light-activated ruthenium complexes disable NDM-1, the β-lactamase driving carbapenem resistance in Gram- bacteria Harmless in the dark but lethal under blue light—Ru1 destroys the enzyme’s active site to restore meropenem potency >50-fold Photochemical precision medicine for AMR!
- Santa Barbara #Hometown #Thanksgiving
- Some real "Mutual of Omaha's Wild Kingdom" action this Thanksgiving morning on a light pole one block from my house — a magnificent Osprey with his half-eaten fish and a crow that thinks he should share — watch the video with the sound on to hear them haggle it out
- though not as common as Graham-negative crackers, Graham-positive ones are the most tasty
- hyaluronic acid has been a significant player in the cosmetic market in recent years — so now it seems sialic acid is giving it a shot #glycotime
- "𝙒𝙞𝙩𝙝 8 𝙞𝙣 10 𝙥𝙖𝙩𝙞𝙚𝙣𝙩𝙨 𝙚𝙣𝙩𝙚𝙧𝙞𝙣𝙜 𝙖 𝙝𝙤𝙨𝙥𝙞𝙩𝙖𝙡 𝙘𝙖𝙧𝙧𝙮𝙞𝙣𝙜 𝙙𝙧𝙪𝙜-𝙧𝙚𝙨𝙞𝙨𝙩𝙖𝙣𝙩 𝙗𝙖𝙘𝙩𝙚𝙧𝙞𝙖, 𝙄𝙣𝙙𝙞𝙖 𝙣𝙤𝙬 𝙨𝙞𝙩𝙨 𝙖𝙩 𝙩𝙝𝙚 𝙘𝙚𝙣𝙩𝙧𝙚 𝙤𝙛 𝙖 𝙨𝙞𝙡𝙚𝙣𝙩 𝙜𝙡𝙤𝙗𝙖𝙡 𝙘𝙧𝙞𝙨𝙞𝙨, 𝙛𝙤𝙧𝙘𝙞𝙣𝙜 𝙙𝙤𝙘𝙩𝙤𝙧𝙨 𝙩𝙤 𝙪𝙨𝙚 𝙡𝙖𝙨𝙩-𝙡𝙞𝙣𝙚 𝙢𝙚𝙙𝙞𝙘𝙞𝙣𝙚𝙨, 𝙧𝙖𝙞𝙨𝙞𝙣𝙜 𝙧𝙞𝙨𝙠𝙨 𝙞𝙣𝙨𝙞𝙙𝙚 𝙝𝙤𝙨𝙥𝙞𝙩𝙖𝙡𝙨 𝙖𝙣𝙙 𝙩𝙧𝙞𝙜𝙜𝙚𝙧𝙞𝙣𝙜 𝙪𝙧𝙜𝙚𝙣𝙩 𝙦𝙪𝙚𝙨𝙩𝙞𝙤𝙣𝙨 𝙤𝙣 𝙥𝙪𝙗𝙡𝙞𝙘 𝙝𝙚𝙖𝙡𝙩𝙝, 𝙨𝙖𝙮𝙨 𝙖 𝙣𝙚𝙬 𝙇𝙖𝙣𝙘𝙚𝙩 𝙨𝙩𝙪𝙙𝙮"
- Zengler Lab @UCSan Diego coralME, a next-gen tool that rapidly builds genome-scale models for 495 gut microbes—models revealing what each microbe eats, what it produces, and how diet and disease reshape microbiome chemistry—clear mechanistic window into biology of IBD www.cell.com/action/showP...
- A REAL PHAGE TURNER Great work in Nat Comm from the UC San Diego laboratories of David Pride and Justin Meyer—experimental evolution of bacteriophage to successfully expand their host range against MDR strains of the critical threat pathogen Klebsiella pneumoniae. www.nature.com/articles/s41...
- New in Science: Ulcerative colitis-derived Aeromonas strain produces aerolysin that is far more toxic to macrophages than epithelial cells In mice, the same isolate colonizes, depletes macrophages, and triggers colitis—recapitulating the macrophage loss seen in UC patients Toxin as drug target?
- Wonderful celebration of the illustrious UCSD career of beloved scientist and mentor 𝐏𝐀𝐋𝐌𝐄𝐑 𝐓𝐀𝐘𝐋𝐎𝐑, 𝐏𝐡𝐃—former Chair of Pharmacology and Founding & Emeritus Dean of our Skaggs School of Pharmacy—two day symposium of trainees and collaborators culminating with paella + acetylcholine cake chez Taylor!
- IYKYK
