Journal of Experimental Medicine
Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, and neurobiology research. Published by Rockefeller University Press @rupress.org
🌐 rupress.org/jem
- DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells. New study from Emily Siniscalco, Courtney Fisher, Meng-Ping Lu, Stephanie Eisenbarth @yaleschoolofmed.bsky.social, Uthaman Gowthaman @umasschan.bsky.social and colleagues: rupress.org/jem/article/... #LymphocyteBiology
- Epigenetic and metabolic reprogramming support plasma cell differentiation in germinal centers, say Yuliang Wang, Xinyi Yang, Yunli Wang, Xiaoming Wang, Jingjing Chen (Nanjing Medical University) and colleagues: rupress.org/jem/article/... #LymphocyteBiology #Epigenetics #Metabolism
- In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation. New study from Lesly Calderón @lesly-calderon.bsky.social, Meinrad Busslinger and colleagues @impvienna.bsky.social: rupress.org/jem/article/... #Hematopoiesis
- JEM’s February issue is here! rupress.org/jem/issue/22... 🔬 The cover depicts fibroblastic reticular cells and vascular smooth muscle cells surrounding a high endothelial venule in a murine lymph node. See Kurz et al. (doi.org/10.1084/jem....)
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- Siniscalco, Fisher, Lu, Eisenbarth, Gowthaman et al. reveal that DOCK8 and STAT3 cooperate in CD4⁺ T cells to restrain Tfh13 differentiation and prevent food-specific IgE. rupress.org/jem/article/... #LymphocyteBiology #MucosalImmunology #HumanDiseaseGenetics
- Yuliang Wang, Xinyi Yang, Jingjing Chen et al. demonstrate CD205 is upregulated in pre-plasma cells. The H3K27 demethylase Kdm6b, not Kdm6a, allows prePCs to become bona fide PCs by removing H3K27me3 marks at the Irf4 locus. rupress.org/jem/article/... #LymphocyteBiology #Epigenetics #Metabolism
- @lesly-calderon.bsky.social, Busslinger et al. @impvienna.bsky.social describe an in vivo #CRISPR/Cas9 screening system for identifying novel regulators of B cell activation and plasma cell development in the context of the splenic microenvironment of immunized mice. rupress.org/jem/article/...
- Explore new #Immunology papers incl. antitumor T cell responses, intestinal #MucosalImmunology, metabolic adaptation in Th2 responses, #myeloid cells ontogeny & the impacts of #circadian checkpoints on their function, and local B cell alterations in #neuroinflammation. 👉 rupress.org/jem/collecti...
- @jengommerman.bsky.social lab reveals that dynamic changes in the brain, leptomeninges, & dural B cells are associated w/ age-dependent disease severity in an animal model of progressive #MultipleSclerosis rupress.org/jem/article/... 📘 #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
- MHC one–two punch knocks out #cancer. Amir Ghorbani and Jonathan Yewdell @niaidnews.bsky.social discuss new study by Zhang, Chamoto and colleagues @ccii-kyoto.bsky.social (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/... #TumorImmunology #Immunotherapy
- Oral antigen exposure under co-stimulation blockade induces Treg cells to establish immune #tolerance. From Masaya Arai, Ryoji Kawakami, Shimon Sakaguchi and colleagues: rupress.org/jem/article/... 📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
- SLC7A8 is essential for metabolic fitness and function of Th2 cells. From Santosh Panda, Marco Colonna and colleagues: rupress.org/jem/article/... 📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
- XPR1 regulates fetal liver #macrophage development, identity and pyrenocyte clearance, say Sebastian Stifter, Melanie Greter and colleagues: rupress.org/jem/article/... 📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
- Chimeric MHC class I and II-restricted non-self epitopes broaden anti-tumor T cell reactions. From Rongsheng Zhang, Tasuku Honjo, Kenji Chamoto and colleagues: rupress.org/jem/article/... 📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
- Fibroblast diversity within human gut-associated lymphoid tissues. From Urs Mörbe (@ursmoerbe.bsky.social), William Agace and colleagues: rupress.org/jem/article/... 📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
- Aroca-Crevillén, @drusqui.bsky.social et al. identify a #circadian checkpoint in #neutrophils, mediated by the CXCL12–CXCR4 axis, that limits tissue injury by inhibiting their intrinsic circadian clock. rupress.org/jem/article/... 📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
- Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood. From LeBlanc, Sobel, @mikerobe.bsky.social and colleagues: rupress.org/jem/article/... 📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
- Cunzhen Li et al. find that in #Paneth cells, ERAdP senses c-di-AMP derived from intestinal microbiota, activating dense core vesicle biogenesis and AMP secretion to enhance intestinal defense. rupress.org/jem/article/... 📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
- #Claudin 1-mediated positioning of DC1 to mTECs is essential for maintenance of central #tolerance. From Jiří Březina, Dominik Filipp and colleagues @imgprague.bsky.social: rupress.org/jem/article/... 📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
- Explore the latest #Immunology research, incl. antitumor T cell responses, central & peripheral #tolerance establishment and maintenance, intestinal #MucosalImmunology, metabolic adaptation in Th2 responses, and more, to accompany @midwinter-immun.bsky.social conference 👉 rupress.org/jem/collecti...
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- Ghorbani and Yewdell discuss work by Zhang et al. (rupress.org/jem/article/...), which describes complete T cell antigens, comprised of class I & class II immunogenic peptides fused in a single polypeptide that greatly increase the effectiveness of #cancer #immunotherapy rupress.org/jem/article/...
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- Explore the 2025 𝘉𝘦𝘴𝘵 𝘰𝘧 𝘑𝘌𝘔 papers in basic #immunology, #immunotherapy and #TumorImmunology, #InbornErrorsOfImmunity, #neurodegeneration, and #inflammation 👉 rupress.org/jem/collecti... THANK YOU to our authors, reviewers, and readers for your interest and continued support for JEM!
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- Join the #EMBL conference "The new cardiobiology: engineering, vascular, and molecular insights," 🗓️ February 16-19. Register for virtual attendance by February 9 👉 www.embl.org/about/info/c... #EMBLCardioBiology @events.embl.org
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- 🌐 Early registration deadline is approaching for @keystoneSymposia.bsky.social meeting, #Aging: #Immune Function & #OrganHealth, March 22-25 in Banff 🏔️ Register here 👉 www.keystonesymposia.org/conferences/... #KSAging26
- 🌐 Early registration deadline is approaching for @keystoneSymposia.bsky.social meeting, #InnateImmunity: Diversity in #HostDefense & Disease, March 22-25 in Banff 🏔️ Register here 👉 www.keystonesymposia.org/conferences/... #KSInnateImmune26
- Spatiotemporal dynamics of fetal liver hematopoietic niches. From Mesquita Peixoto, Soares-da-Silva, Bonnet, Zhou, Baroud, Pinto-do-Ó, Cumano, and colleagues 👉 rupress.org/jem/article/... 📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
- 📢 JEM is delighted to introduce the 2026 Associate Editors: Semir Beyaz, Coco Chu, Erin M. Gibson (@erinmgibson.bsky.social), Benjamin G. Hale (@benhale.bsky.social), Guideng Li, Esther Obeng, João Pereira, and Pamela Rosato. Welcome! 👉 rupress.org/jem/pages/as...
- 🌐 Explore emerging research w/ field leaders @keystoneSymposia.bsky.social #CancerImmunotherapy: Mechanisms, Clinical Advances & Combinations, March 15-18 in Québec 🏰 JEM's Senior Editor @montse-jexpmed.bsky.social is attending! Register 👉 www.keystonesymposia.org/conferences/... #KSCancerImmune26
- Single-cell and spatial profiling highlights #TB-induced myofibroblasts as drivers of lung pathology. From Ian Mbano, Nuo Liu, Paul Elkington @unisouthampton.bsky.social, Alex Shalek @mit.edu, Alasdair Leslie (Africa Health Research Institute) et al: rupress.org/jem/article/... #Tuberculosis
- 🌐 Explore emerging research with field leaders @keystoneSymposia.bsky.social #MyeloidCells : Heterogeneity & Therapeutic Promise, February 23-26 in Keystone🌲 JEM's Deputy Editor Gaia Trincucci @gaiajexpmed.bsky.social is attending! Register 👉 www.keystonesymposia.org/conferences/... #KSMyeloid26
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- Amir Ferry, Ananda Goldrath et al. show that differentiation of tissue-resident memory T cells (TRM) is accompanied by the upregulation of the conventional DC1 (cDC1) chemoattractant, Xcl1. rupress.org/jem/article/... 📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
- 🌐 Explore emerging #Hematopoiesis research with field leaders @keystoneSymposia.bsky.social, February 23-26 in Keystone🌲 JEM's Deputy Editor Gaia Trincucci @gaiajexpmed.bsky.social is attending! Register now 👉 www.keystonesymposia.org/conferences/... #KSHemato26
- The cribriform plate: A dynamic central nervous system immune hub. New review from Collin J. Laaker, Zsuzsanna Fabry and colleagues @uwmadison.bsky.social: rupress.org/jem/article/... #Neuroscience #Neuroinflammation
- Native stem cell transcriptional circuits define cardinal features of high-risk #leukemia. From Qing Wang, Francesco Boccalatte, Jason Xu, Iannis Aifantis, Mark Chiang and colleagues 👉 rupress.org/jem/article/... 📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
- #Claudin 1-mediated positioning of DC1 to mTECs is essential for maintenance of central #tolerance. New study from Jiří Březina, Dominik Filipp and colleagues @imgprague.bsky.social @czechacademy.bsky.social: rupress.org/jem/article/... #Autoimmunity #DendriticCells
- Molecular and phenotypic blueprint of human #hematopoiesis links proliferation stress to #StemCell #aging. New study from Emanuele Lettera, Raffaella Di Micco @dimiccolab.bsky.social and colleagues: rupress.org/jem/article/... #TechnicalAdvances #Resources #StemCells
- Transcription of #HIV-1 is heterogenous among authentic latent CD4+ T cell clones, say Cintia Bittar, Michel C. Nussenzweig @rockefeller.edu and colleagues: rupress.org/jem/article/... #InfectiousDisease #HostDefense #Virology
- ERAdP facilitates biogenesis of dense core vesicles in #Paneth cells to enhance intestinal defense, say Cunzhen Li, Zhen Xiong, Deyuan Kong, Yun Chen, Qiang Zhan, Zusen Fan (Institute of Biophysics, Chinese Academy of Sciences) and colleagues: rupress.org/jem/article/... #InfectiousDisease #IBD
- FOXO1 re-expression with a dual-recombinase allele rescues class switching in germinal center B cells, say Carlota Farré Díaz, Eleni Kabrani, Klaus Rajewsky and colleagues @mdc-berlin.bsky.social: rupress.org/jem/article/... #LymphocyteBiology
- Estrogen influences class-switched memory B cell frequency only in humans with two X chromosomes. From @hlpeks.bsky.social, @emmaschambers.bsky.social, @bcellsrosser.bsky.social, Ciurtin et al. 👉 rupress.org/jem/article/... 📘 In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
- Tet2 deficiency–induced expansion of monocyte-derived #macrophages promotes liver #fibrosis Jiuxing Feng, Baitong Wu, Yujiang Geno Shi and colleagues (Fudan University): rupress.org/jem/article/... #Hematopoiesis #InnateImmunity #Inflammation
- T cell engagers emerge as a compelling therapeutic modality. New review from Baeuerle, Grieshaber-Bouyer, Sauer, and Michaelson: rupress.org/jem/article/... #CancerFocus #TumorImmunology #TcellEngagers
- Transient inhibition of type I interferon enhances CD8⁺ T cell stemness and #vaccine protection. From Benjamin Broomfield @benjbroom.bsky.social, Joanna Groom @groomlab.bsky.social and colleagues 👉 rupress.org/jem/article/... 📘 In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
- Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design. From Kevin Groen, Benjamin Hale (@benhale.bsky.social) and colleagues 👉 rupress.org/jem/article/... 📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti... #Autoimmunity
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- Sirimuvva Tadepalli, Derek Clements, Juliana Idoyaga @idoyagalab.bsky.social and colleagues reveal that CD301b⁺ monocyte-derived dendritic cells mediate resistance to #radiotherapy 👉 rupress.org/jem/article/... 📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
- In a new study from Mbano, Liu, Leslie et al., single-cell and spatial transcriptomics of human #TB lung tissues from individuals in South Africa revealed that MMP1⁺CXCL5⁺ #fibroblasts & SPP1⁺ #macrophages are linked to TB disease & TB lung #granuloma rupress.org/jem/article/... #InfectiousDisease
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- Březina et al. @czechacademy.bsky.social show that #Claudin 1 enables thymic type 1 #DendriticCells to localize in close proximity to medullary thymic epithelial cells, supporting the maturation & tolerogenic function of type 1 dendritic cells rupress.org/jem/article/... #Tolerance #Autoimmunity
- Review: The cribriform plate is a skull region where olfactory nerves link the nasal cavity and brain. Laaker, Fabry et al. review evidence that this interface also acts as a gateway between the CNS and the peripheral immune system, with relevance to neuropathologies. rupress.org/jem/article/...htt
- Lettera et al. @dimiccolab.bsky.social show that human #hematopoiesis across #aging is characterized by stable #StemCell numbers and reduced erythroid/lymphoid output. rupress.org/jem/article/... #TechnicalAdvances #Resources #StemCells
- RORγt eTACs mediate oral #tolerance and Treg induction. From Im-Hong Sun, Anita Qualls, Han Yin, James Gardner @gardnerlabucsf.bsky.social and colleagues 👉 rupress.org/jem/article/... 📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
