Waggoner Lab
Focused on innate immune mechanisms governing pathogenesis of disease and on NK-cell based therapies for disease. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer.
- Intranasal CR9114 is safe in humans, and twice-daily dosing confers protection against influenza virus challenge in macaques www.science.org/doi/10.1126/...
- The E205D point mutation in the key detoxification gene CYP6P3 increases insecticide resistance in the malaria vector Anopheles gambiae www.science.org/doi/10.1126/...
- Overcoming host restrictions to enable continuous passaging of GII.3 human norovirus in human intestinal enteroids www.science.org/doi/10.1126/...
- Ketogenic diet alleviates septic lung injury via microbial gut-lung axis @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...
- Lactate, an aerobic glycolysis product, promotes NLRP3 inflammasome activation and pyroptosis, driving inflammatory responses in polymicrobial sepsis www.cell.com/cell-chemica... @cp-cellchembiol.bsky.social
- In a preclinical breast cancer metastasis model, the same bacteria strain, when present intracellularly versus extracellularly, exerts opposing effects on tumor immunity by inducing divergent neutrophil states @cellcellpress.bsky.social www.cell.com/cell/fulltex...
- Inhibitory NK receptor expression associates with altered antimalarial function of γδ T cells journals.plos.org/plospathogen...
- During fungal and viral infection, T-cell-intrinsic cytoplasmic NAD/H synthesis via NRK1 maintains effector CD4+ T cell abundance within affected tissues and draining lymph nodes @natcomms.nature.com @birminghamliver.bsky.social www.nature.com/articles/s41...
- Mosquito–capsid interactions contribute to flavivirus vector specificity @nature.com www.nature.com/articles/s41...
- Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes @nature.com @astrazeneca.bsky.social www.nature.com/articles/s41...
