Kranzusch Lab
Harvard Medical School, Dana Farber Cancer Institute
https://kranzuschlab.med.harvard.edu
- Reposted by Kranzusch LabAmazing findings in geometry-based immune activation! Two bacterial defence systems detect phage-encoded ring oligomers, assemble high-order molecular complexes, and trigger abortive infection. www.nature.com/articles/s41... www.nature.com/articles/s41...
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- Reposted by Kranzusch LabNew #glycotime discovery from @raflynn5.bsky.social’s lab @bostonchildrens.bsky.social @harvard.edu, cell surface glycoRNA-RBP complexes organized by heparan sulfate PG nanoclusters that modulate VEGF signaling www.nature.com/articles/s41...
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- Reposted by Kranzusch LabNow out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake! rdcu.be/e1bBW
- Great new story from Sophie Helaine and Molly Sargen! www.helainelab.com
- A prophage-encoded abortive infection protein preserves host and prophage spread www.nature.com/articles/s41...
- Excited to help share that Sam Hobbs @hobbslabutah.bsky.social from our group has launched his independent lab at the University of Utah studying host-virus interactions. Congratulations Sam, we can't wait to see the new discoveries your lab will make! hobbs.biochem.utah.edu
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- Reposted by Kranzusch LabI’m thrilled to share our work on phage triggers of the bacterial immune system in its final form @natmicrobiol.nature.com www.nature.com/articles/s41...
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- New structures of the HSV-1 helicase-primase complex from @abrahamlabhms.bsky.social www.cell.com/cell/fulltex...
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- Reposted by Kranzusch LabVaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there?? #CellBiology #WTFology www.biorxiv.org/content/10.6...
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- Exciting pre-print on new variants of anti-phage defense systems including CBASS, Pycsar, and Gabija! www.biorxiv.org/content/10.6...
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- Gluing a bulky host protein onto an immune surveillance complex is a wild mechanism of viral immune evasion! @natmicrobiol.nature.com #phagesky #phage #microsky www.nature.com/articles/s41...
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- Reposted by Kranzusch LabHi everyone, a few years ago, we started a list of labs studying bacterial immunty for students, editors, conference organizers... (currently n=79). Update time ! Send me a message to 1) add your lab or others 2) Correct info docs.google.com/spreadsheets... #Phagesky #Microsky
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- Reposted by Kranzusch LabThe Wilkinson Lab is open for science! @mskcancercenter.bsky.social 🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬 annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)
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- Reposted by Kranzusch LabHow does life evolve to adapt to modern cities? Out now in Science, my PhD work with @lindymcbr.bsky.social uncovers the ancient origin of the “London Underground mosquito” – one of the most iconic examples of urban adaptation. 🧵(1/n) @science.org www.science.org/doi/10.1126/science.ady4515
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- Reposted by Kranzusch Lab🚨 Systems Virology Journal Club – 8th Series! 🚨 #BillSchneider and I are delighted to announce another round of cutting-edge talks in #SystemsVirology! 🦠💡 Join us and an outstanding lineup of speakers, starting Oct 30. Free registration: shiraweingartengabbay.com/systems-viro... 🔬✨
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- Reposted by Kranzusch Lab1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria. www.biorxiv.org/content/10.1...
- Perfect timing in the field for a beautiful review on NAD+ in bacterial immunity by @hugovaysset.bsky.social and @audeber.bsky.social @cp-molcell.bsky.social #MicroSky www.cell.com/molecular-ce...
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