Doudna Lab
News from Jennifer Doudna's lab at UC Berkeley, Innovative Genomics Institute. Tweets from lab members and not Jennifer Doudna unless signed JD. Tweets represent personal views only.
doudnalab.org
- 🚀 New preprint! @jacobsenucla.bsky.social x @doudna-lab.bsky.social collaboration: High-activity TnpB (Ymu1-WFR) + a multi-gRNA system in TRV enables heritable, tissue-culture-free multiplex editing in plants. Big potential for plant biotech 🧬🌾🌱 doi.org/10.64898/202...
- Reposted by Doudna LabHow do the ancestors of CRISPR-Cas unwind DNA and how can this lead to better genome editing? With our collaboration between @doudna-lab.bsky.social x @jacobsenucla.bsky.social x Zev Bryant's lab x @savagecatsonly.bsky.social we've uncovered the secrets behind TnpB's dynamics!
- Reposted by Doudna LabCheck out the latest episode of Rewriting the Code, featuring Jennifer Doudna and #SickleCell patient pioneer Victoria Gray who was cured with a #CRISPR-based treatment in a groundbreaking clinical trial: ow.ly/t6FY50XVNO7
- Reposted by Doudna LabTargeted delivery of genome editors in vivo - @doudna-lab.bsky.social @innovativegenomics.bsky.social go.nature.com/4qKp6Tb
- New preprint 👉Doudna x Bryant x Jacobsen x Savage collaboration! Work led by @zehanzhou.bsky.social, I. Saffarian-Deemyad, @honglue.bsky.social, T. Weiss We dissect how stepwise DNA unwinding gates TnpB genome editing, revealing how unwound DNA states enhance cleavage www.biorxiv.org/content/10.6...
- Reposted by Doudna LabNew in Science Magazine Science Advances from the Doudna Lab, Rubin Lab and Cress Lab —Identification of proteins influencing #CRISPR-associated #transposases for enhanced #GenomeEditing. Read here: ow.ly/U0s450XS82n
- Reposted by Doudna LabDuring my postdoc in @therubinlab.bsky.social, @leosong.bsky.social and I aimed to make CRISPR-associated transposons more efficient for editing bacteria. Couldn’t have done it w/o a CAST of characters at IGI and beyond @innovativegenomics.bsky.social, @cresslab.bsky.social, @doudna-lab.bsky.social
- Happy New Year from the Rubin Lab! 🎇 We're excited to start 2026 off with a fresh publication at @science.org Advances. Here, we identified a cast (😉) of host factors affecting VchCAST using genome-wide screens and validated their improvement or inhibition of CAST activity. (1/2)
- Reposted by Doudna Lab🎺New paper alert🎺 Out now in Nature Chemical Biology from IGI's Jennifer Doudna (Doudna Lab) and collaborators: Temporal photoproximity labeling of ligand-activated EGFR neighborhoods using MultiMap Read here: ow.ly/izGo50XAkog
- Reposted by Doudna LabExcited to share our work designing genome editors with machine learning! 🧬💻 Huge thanks to @petrskopintsev.bsky.social @isabelesain.bsky.social @doudna-lab.bsky.social and all co-authors. Check out the thread for a summary of what we found 👇
- ✨New preprint! 🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al! Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬 🔗👇
- Reposted by Doudna LabA very nice Preview of our work in @cp-cellhostmicrobe.bsky.social this morning from Chrishan Fernando & Nicole D. Marino! www.cell.com/cell-host-mi...
- Reposted by Doudna LabCongrats to IGI's Jill Banfield, Jennifer Doudna, Mary Firestone, Patrick Hsu, Alex Marson, Kris Niyogi, Eva Nogales, Dan Nomura, and Jennifer Puck — each is on Clarivate's Highly Cited Researchers 2025 list for ranking in the top 1% in their field by citations!
- Reposted by Doudna LabExcited to share our first work on protein design! Huge thanks to the entire team, and especially to Bel, Evan, to the Doudna, Jacobsen, Cate, Banfield labs, all co-authors, and my D-lab mates! 💫
- ✨New preprint! 🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al! Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬 🔗👇
- Reposted by Doudna LabFirst co-led work from the Doudna lab 🤜🤛 We designed minimal RNA-guided nucleases with AI, and even did Cryo-EM during an earthquake (!) Huge honor working with @petrskopintsev.bsky.social, @evandeturk.bsky.social, Jennifer Doudna and co-authors, everyone at D-Lab and @innovativegenomics.bsky.social
- ✨New preprint! 🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al! Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬 🔗👇
- ✨New preprint! 🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al! Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬 🔗👇
- 🧵2/4 By coupling inverse folding with evolutionary information, we generated highly active and diverse variants with a high design success rate ⚙️
- 🧵3/4 We assessed activity using a high-throughput bacterial assay, followed by editing the human and plant genomes 🧫🌱
- 🧵4/4 We solved the first experimental structure of an AI-designed RNA-guided nuclease, which revealed new protein-nucleic acid contacts across conformational states. 🔗 See our preprint: www.biorxiv.org/content/10.6...
- Reposted by Doudna LabCareer update: I'm happy to say that I've accepted a postdoc position at UC Berkeley at @innovativegenomics.bsky.social in Jennifer Doudna's lab! I'm looking forward to this exciting new chapter of my scientific career!
- Reposted by Doudna LabWe're excited to share our lab's first lead paper! We developed OriGen, a language model trained to generate plasmid origins of replication. 🔄🦠 The model generates sequences that are significantly different from wild type origins and, remarkably, they allow for replication in vivo. Read it here ⬇️
- Reposted by Doudna Lab1/2 New from co-first authors @erinedoherty.bsky.social and @jnoms.bsky.social of the @doudna-lab.bsky.social — Bacteria fight off viruses using tiny molecular “alarm signals” made of nucleotides. To survive, viruses must find ways to shut these signals down.
- Reposted by Doudna LabMy lab is hiring postdocs! We combine AI, protein structure prediction and comparison, and high-throughput virology to study the virus-host conflict. You can read more about my lab's research here: jasonnomburg.com/research/ Apply here to join us in lovely Vienna! aithyra.onlyfy.jobs/job/0khkxp82
- The Starting Principal Investigators at #AITHYRA the Research Institute for Biomedical Artificial Intelligence of the OeAW in Vienna invite outstanding candidates to apply for postdoctoral positions in the field of AI/ML & Life Sciences. www.oeaw.ac.at/aithyra/post... Please apply by 20 Nov 2025!
- Reposted by Doudna LabSo happy to see this work out! Was such a pleasure to co-lead this effort with Erin. Do you like viral immune evasion, and using protein structure to study immune antagonists? Give it a read!
- Work I co-led with @jnoms.bsky.social is now online at @cp-cellhostmicrobe.bsky.social ! We revealed a previously unrealized diversity of viral immune-evasion proteins that selectively destroy different cyclic nucleotide signals used in bacterial immunity. www.sciencedirect.com/science/arti...
- Reposted by Doudna LabWork I co-led with @jnoms.bsky.social is now online at @cp-cellhostmicrobe.bsky.social ! We revealed a previously unrealized diversity of viral immune-evasion proteins that selectively destroy different cyclic nucleotide signals used in bacterial immunity. www.sciencedirect.com/science/arti...
- Now online at @cp-cellhostmicrobe.bsky.social from co-first authors @erinedoherty.bsky.social & @jnoms.bsky.social
- Work I co-led with @jnoms.bsky.social is now online at @cp-cellhostmicrobe.bsky.social ! We revealed a previously unrealized diversity of viral immune-evasion proteins that selectively destroy different cyclic nucleotide signals used in bacterial immunity. www.sciencedirect.com/science/arti...
- Reposted by Doudna LabNew in Science Magazine from the Doudna Lab and first author Owen Tuck: Recurrent acquisition of nuclease-protease pairs in antiviral immunity. Read here: ow.ly/pIWQ50XtEtM
- Reposted by Doudna LabNew from the @doudna-lab.bsky.social and first author @owentuck.bsky.social!
- Our nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems: www.science.org/doi/10.1126/... Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
- Reposted by Doudna LabOur nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems: www.science.org/doi/10.1126/... Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
- Reposted by Doudna LabI'm hiring a lab technician to help me explore some exciting new questions about virus-host interactions! Biochemistry and/or mammalian cell culture experience is desired.
- Apply to work with us! careerspub.universityofcalifornia.edu/psc/ucm/EMPL...
- Apply to work with us! careerspub.universityofcalifornia.edu/psc/ucm/EMPL...
- Reposted by Doudna LabThank you to the Blavatnik Family Foundation and The New York Academy of Sciences for honoring our research uniting human innate immunity and bacterial anti-phage defense at @danafarber.bsky.social @harvardmicro.bsky.social @harvard.edu bit.ly/4pZUDkF blavatnikawards.org/news/items/t...
- Congratulations to my colleagues Omar Yaghi and John Clarke — the two latest UC Berkeley Nobel Laureates! Omar’s development of metal-organic frameworks changed the way we capture carbon, store energy, and harvest water from desert air. shorturl.at/GpBsu 1/2
- John and his collaborators' work is the foundation for the breakthroughs in quantum computing that will transform the way we do science for decades to come. Omar and John are shining examples of what makes Berkeley a magnet for top innovators around the world. – Jennifer Doudna shorturl.at/pJlH4 2/2
- "Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)
- "Her work made it impossible to separate what we learn from our obligation to protect it. Generations of researchers have tried to follow that example." - Jennifer Doudna (2/2)
- Reposted by Doudna Labthen turned that knowledge into a global movement for conservation. Her work made it impossible to separate what we learn from our obligation to protect it. Generations of researchers have tried to follow that example." 2/2
- Reposted by Doudna LabFrom IGI Founder Jennifer Doudna: "Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats... 1/2
- Now online at @nature.com we show how the Panoptes defense system protects against viruses that attempt immune evasion - and expands our understanding of the role of oligonucleotides in immunity. Check out this work co-led with @benadler.bsky.social here: www.nature.com/articles/s41...
- Published alongside complementary work from our friends @benmorehouse.bsky.social & @aaronwhiteley.bsky.social, led by @aesully98.bsky.social www.nature.com/articles/s41...
- Reposted by Doudna LabOur story describing the Panoptes bacterial immune defense system is now finally peer-reviewed and published today! www.nature.com/articles/s41...
- Reposted by Doudna LabBacteria use a decoy defense molecule to set a trap for viruses @doudna-lab.bsky.social @ucberkeleyofficial.bsky.social @ucirvine.bsky.social @aaronwhiteley.bsky.social @colorado.edu @aesully98.bsky.social www.nature.com/articles/d41... www.nature.com/articles/s41... www.nature.com/articles/s41...
- Reposted by Doudna LabToday in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems. Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here: www.nature.com/articles/s41...
- Reposted by Doudna LabOut today in @nature.com, a new paper from @doudna-lab.bsky.social lab, co-first authors @erinedoherty.bsky.social + @benadler.bsky.social and collaborators at @ucsandiego.bsky.social unveils a powerful new defense strategy in the arms war between viruses + microbes. Read here: ow.ly/mPQI50X5g68
- Congrats to Doudna lab postdoc @erinedoherty.bsky.social! 🎊
- Congrats to our 2025 MCB Outstanding Postdoc Award recipients who are being honored for their excellence in research, leadership, and service! 👏🎉Erin Doherty @erinedoherty.bsky.social, Kevin Eislmayr, Naohiro Kuwayama, & Joseph Lobel mcb.berkeley.edu/news-and-eve...
- New pre-print from Doudna lab members @erinedoherty.bsky.social & @jnoms.bsky.social ✨ Here we explore how recurrent adaptation of a single anti-defense protein fold enables evasion of distinct immune systems.
- Excited to share our new preprint co-led by @jnoms.bsky.social! Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.
- Reposted by Doudna Lab@jenniferdoudna.bsky.social @doudna-lab.bsky.social talks about the history and future of #CRISPR with Cleo Abram! Check out the interview: www.youtube.com/watch?v=0OXa...
- Reposted by Doudna LabIn a recent paper, IGI's @jenniferdoudna.bsky.social @doudna-lab.bsky.social and Jill Banfield @banfieldlab.bsky.social collaborate with UCLA's @jacobsenucla.bsky.social to create a new, tiny #CRISPR tool for quicker, easier plant genome editing! Read more in this Q&A with Steve: ow.ly/6Szs50VGElf
- ‼️ New pre-print from co-leads @owentuck.bsky.social and Jason Hu! Check out this fascinating example of how coevolution enables defense system innovation.
- Excited to finally share this work! We noticed a pair of genes - a nuclease and a protease - shuffles between antiviral systems. We show how proteolysis activates the nuclease, triggering defense in known and unknown immune contexts. tinyurl.com/2uwwy4ty
- Reposted by Doudna LabA new Pediatric Center for CRISPR Cures builds on the recent saved life of Baby KJ, who expeditiously had bespoke in vivo base genome editing @jenniferdoudna.bsky.social @doudna-lab.bsky.social @innovativegenomics.bsky.social @chanzuckerberg.bsky.social erictopol.substack.com/p/new-center...
- Reposted by Doudna Lab“What we’ve done here is uncover the secret sauce that makes typical #Cas9 — the original Nobel molecule — so efficient and precise." – Co-first author Honglue Shi of the @doudna-lab.bsky.social on his recent paper in Molecular Cell Read here: innovativegenomics.org/uncovering-c...
- Reposted by Doudna LabThanks to the BBC's The Inquiry program for great conversations with IGI's @jenniferdoudna.bsky.social @doudna-lab.bsky.social and @urnov.bsky.social about Baby KJ, #CRISPR on-demand, and the future of personalized medicine! Listen here: www.bbc.com/audio/play/w... Photo credit: TODAY
- Registration is open for the 2025 Computational Structural Virology Symposium, featuring Doudna lab postdoc @jnoms.bsky.social!
- Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!
- Reposted by Doudna LabHello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!
- Reposted by Doudna LabUS supercomputer named after Nobel laureate Jennifer Doudna @jenniferdoudna.bsky.social @innovativegenomics.bsky.social to power AI and scientific research apnews.com/article/nvid...
- Congratulations to Matt on this incredible accomplishment! 🎉This K08 will allow him to continue developing CRISPR based therapies for children with inherited immune diseases.
- Reposted by Doudna LabElated to share that I was awarded a K08 clinician-scientist research career development award from the National Institutes of Allergy and Infectious Diseases!
- Congrats to Doduna lab postdoc @erinedoherty.bsky.social for being selected as a Leading Edge Fellow! @leadingedgeprogram.bsky.social
- We are thrilled to announce the 2025 Leading Edge Fellows! 40 outstanding postdoctoral fellows doing pioneering research in a wide range of biological and biomedical disciplines. Learn more about these exceptional scientists: www.leadingedgesymposium.org/fellows
- Reposted by Doudna LabCongrats to Dr. Honglue Shi @honglue.bsky.social on his latest research! The importance of weak, yet specific, interactions 👀 @doudna-lab.bsky.social @cellpress.bsky.social
- Now online at Molecular Cell! What makes SpyCas9 such an efficient editor? Read more at: www.cell.com/molecular-ce... Congrats @honglue.bsky.social, Noor Al-Sayyad, and @kevinwasko.bsky.social!
- Reposted by Doudna LabIn a new paper, IGI's Jennifer Doudna @doudna-lab.bsky.social and Jill Banfield @banfieldlab.bsky.social collaborate with UCLA's @jacobsenucla.bsky.social to create a new, tiny #CRISPR tool for quicker, easier plant genome editing! Read more: ow.ly/6Szs50VGElf
- Reposted by Doudna LabJennifer Doudna @jenniferdoudna.bsky.social @doudna-lab.bsky.social speaks with Cleo Abrams on the history and future of #CRISPR 🧬. Watch here: youtu.be/0OXaanDHENI?...
- Reposted by Doudna LabNew Heroes portrait of @jenniferdoudna.bsky.social for the @nationalacademies.org. @doudna-lab.bsky.social explorers.com/jennifer-dou...
- Now online at Molecular Cell! What makes SpyCas9 such an efficient editor? Read more at: www.cell.com/molecular-ce... Congrats @honglue.bsky.social, Noor Al-Sayyad, and @kevinwasko.bsky.social!
- “What we’ve done here is uncover the secret sauce that makes typical #Cas9 — the original Nobel molecule — so efficient and precise." – Co-first author @honglue.bsky.social of the @doudna-lab.bsky.social on his new paper out today in Molecular Cell Read here: shorturl.at/p664D
- Reposted by Doudna Lab“What we’ve done here is uncover the secret sauce that makes typical #Cas9 — the original Nobel molecule — so efficient and precise." – Co-first author @honglue.bsky.social of the @doudna-lab.bsky.social on his new paper out today in Molecular Cell Read here: shorturl.at/p664D
- Catch @honglue.bsky.social at the Harvard Genome Engineering Seminar Series this Monday, April 7 at 1pm EST / 10am PST! If you’ve ever wondered why SpyCas9 is so efficient at genome editing, don’t miss his talk—Zoom link: harvard.zoom.us/j/94394339529
- Giving a seminar for the Genome Engineering Seminar Series at Harvard this Monday, April 7 at 1pm EST / 10am PST! 🎙️ I’ll be talking about our Cas9 work—if you’ve ever wondered what the recipe is for high-efficiency CRISPR genome editing, come hang out!🧬💥 📍 Zoom link: harvard.zoom.us/j/94394339529
- Reposted by Doudna Lab🧪🧪🧪10 incredible findings about Cas10-relative, mCpol: result number 10 will surprise you!🧪🧪🧪 @erinedoherty.bsky.social and I teamed up to understand the role and function of Cas10-relative, mCpol, and its role in antiphage immunity. For more, check out Erin's thread 👇
- Preprint alert! ✨ In this project that I co-led with @benadler.bsky.social, we show that a miniature CRISPR-Cas10-like enzyme, mCpol, uses a novel inverse signaling mechanism to prevent the spread of viruses that attempt immune evasion by depleting host cyclic nucleotides. Check it out:
- Reposted by Doudna LabPreprint alert! ✨ In this project that I co-led with @benadler.bsky.social, we show that a miniature CRISPR-Cas10-like enzyme, mCpol, uses a novel inverse signaling mechanism to prevent the spread of viruses that attempt immune evasion by depleting host cyclic nucleotides. Check it out:
- Reposted by Doudna LabNew from @doudna-lab.bsky.social in @narjournal.bsky.social: "Packaged delivery of #CRISPR–Cas9 ribonucleoproteins accelerates genome editing" Read here: shorturl.at/AcZ8i 🧪🧬
- Reposted by Doudna LabPhage genomes are full of mysterious proteins that could be harnessed to create new genomic tools. IGI's @doudna-lab.bsky.social & @cresslab.bsky.social with co-first authors @benadler.bsky.social & Muntathar Jamal Al-Shimary detail a new way to exploring phage genomes: ow.ly/uucL50V77n0 🧪🦠🧬
- Reposted by Doudna LabIn a recent @naturecomms.bsky.social paper, @doudna-lab.bsky.social at the IGI & Michael Jordan’s lab in Cal’s Dept of Electrical Engineering & Computer Science unveil a new #AI-based method to narrow down large datasets of proteins to prioritize what to study in the lab: ow.ly/nxxn50V80fo
- Reposted by Doudna LabThis week, I’ll highlight two recent CRISPR advances: 1) BEAM’s exciting Phase 1 clinical data for BEAM-302. 2) Impressive work from the labs of Scribe’s co-founders @savagecatsonly.bsky.social & @doudna-lab.bsky.social —providing a textbook example of engineering CRISPR enzymes from zero to hero.
- We are so excited to bring more talented students to the IGI! Pictured: Cydni Bolling of Hampton University, who did research in our lab last summer as part of the UC-HBCU Initiative. A special shout-out to her mentor postdoc @erinedoherty.bsky.social who connected IGI with the Initiative.
- The IGI is *thrilled* to announce the Rising Stars Program – a new program to bring talented undergrads from HBCUs to IGI labs at Berkeley, UCSF, UC Davis, and UCLA for summer research in #CRISPR! Learn more: ow.ly/mSkM50Vg7I4
- Reposted by Doudna LabSingle-molecule live-cell RNA imaging with CRISPR–Csm - @doudna-lab.bsky.social @qb3-berkeley.bsky.social @innovativegenomics.bsky.social go.nature.com/3EJPKsM
- Reposted by Doudna LabToday in #journalclub, we looked at this fantastic new method from the @doudna-lab.bsky.social in Nature Biotechnology! They show how CRISPR–Csm enables single-molecule live-cell imaging of endogenous RNAs. Super cool! www.nature.com/articles/s41...
- Reposted by Doudna Lab🧬OUT NOW Functional Genomics of Diverse Bacteriophages Enabled by RNA-Binding CRISPRi by @benadler.bsky.social @doudna-lab.bsky.social @cresslab.bsky.social www.nature.com/articles/s41...
