- ✨New preprint! 🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al! Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬 🔗👇
- 🧵2/4 By coupling inverse folding with evolutionary information, we generated highly active and diverse variants with a high design success rate ⚙️
- 🧵3/4 We assessed activity using a high-throughput bacterial assay, followed by editing the human and plant genomes 🧫🌱Dec 9, 2025 07:52
- 🧵4/4 We solved the first experimental structure of an AI-designed RNA-guided nuclease, which revealed new protein-nucleic acid contacts across conformational states. 🔗 See our preprint: www.biorxiv.org/content/10.6...
