Joe Wanford
Group leader and Wellcome Trust Career Development Fellow at King's College London. Using comparative genomics, microbiology and innate immunology to study Klebsiella virulence. Foodie and below average footballer.
- Reposted by Joe Wanford[Not loaded yet]
- Reposted by Joe WanfordThis is finally out. Very short take home. All the variation in spike that produced the immune escape characteristics of Omicron can occur in one single persistently infected individual over the period of a year. This is why persistent infections matter www.cell.com/cell-reports...
- Reposted by Joe WanfordThis is the sort of strategic planning that should go into #vaccine design 💉 They analysed 1,930 #Klebsiella pneumoniae 🦠🧫🧬 neonate blood isolates from 13 countries and estimate that 20 antigens 🧪 could cover 72.9% of all infections for 5–10 years #IDSky #EpiSky journals.plos.org/plosmedicine...
- Reposted by Joe Wanfordgreat update on #Klebsiella research!
- 🧫 Our publication,“Global perspectives on Klebsiella epidemiology and biology: conference report on the KLEBS 2024 symposium,” is now out! 📄 Link to paper: www.nature.com/articles/s44... @kelwyres.bsky.social @katholt.bsky.social @sylvainbrisse.bsky.social @pasteur.fr
- Reposted by Joe WanfordWe are looking for a new RA to join our team working on host-pathogen interactions during Salmonella infection. The appointment is for two years and you will join a diverse team, using cell and protein biochemistry to further our understanding of pathogenesis. my.corehr.com/pls/uoxrecru...
- Reposted by Joe Wanford
- Reposted by Joe WanfordGut-relevant short-chain fatty acids modulate host-pathogen dynamics of uropathogenic Escherichia coli at the colonic epithelial interface biorxiv.org/content/10.64898/20…
- Reposted by Joe WanfordThe first of some rather chunky papers coming out of Sam Fenn’s work here at @uccmicrobiology.bsky.social Here we identify and characterise yet another way S. aureus survives life in the bloodstream, but remodelling a major part of its metabolism
- Reposted by Joe WanfordNeisseria gonorrhoeae carries an unusually large number of restriction–modification systems (up to 16!), many of which are phase-variable. How does this affect plasmid transmission in gonococci? doi.org/10.64898/202...
- Reposted by Joe Wanford[Not loaded yet]
- Reposted by Joe WanfordI wonder what Londoners know that the rest of the country don’t?
- Reposted by Joe WanfordIn vivo detection of immune responses via cytokine activity labeling @cellcellpress.bsky.social @harvardmed.bsky.social www.cell.com/cell/fulltex...
- Reposted by Joe WanfordNovel genes arise from genomic deletions across the bacterial tree of life biorxiv.org/content/10.64898/20…
- Reposted by Joe WanfordEver wondered if your favorite bacteria 🧫🦠 produce exopolysaccharides? You can now easily check that with epsSMASH, our new bioinformatic tool built on the antiSMASH framework. It detects both known and novel exoPS BGCs. Check out and share the preprint! www.biorxiv.org/content/10.6...
- Reposted by Joe Wanford[Not loaded yet]
- Reposted by Joe Wanford[Not loaded yet]
- Reposted by Joe WanfordPreprint alert📢! Ever wondered how much bacterial parasites influence evolutionary outcomes of their host? ➡️ We co-evolved two bacterial strains in conditions in which the costs and benefits of prophage carriage varied Here is what we found. www.biorxiv.org/content/10.6... #MicroSky #PhageSky 🧵
- Reposted by Joe Wanford[Not loaded yet]
- Reposted by Joe WanfordAbsolutely stoked to have this published in @plosbiology.org We looked at the metabolism of #Klebsiella pneumoniae 🦠🧫. We not only demonstrated lineage-specific #metabolism, but that lineages can cross-feed and support each other. journals.plos.org/plosbiology/... #MicroSky #microbiology 🧬 🧪 💊
- Reposted by Joe Wanford📄 Delighted to share that the preprint of my main PhD work is out now! 👏 A huge thank you to everyone involved, @tommclean.bsky.social, Govind Chandra, Ngat Tran (both not on BlueSky) and especially my PhD supervisor @tunglejic.bsky.social 👏 🧵 below! www.biorxiv.org/content/10.6...
- Reposted by Joe Wanford😳 Reversible phenotypic resistance to phage infection via capsule downregulation in Klebsiella pneumoniae #phage #phageky www.cell.com/iscience/ful...
- Reposted by Joe WanfordVery interesting new protective response in live (!) neutrophils against bacterial infection:
- Thrilled to share that neutrophils produce extra long fibrillar components named proteoglycofili or PGF. PGF are released by living neutrophils and do not contain DNA. They might look like NETs but are not NETs… www.cell.com/cell-reports...
- Reposted by Joe WanfordNow published. Thank you very much to our collaborative team, and very supportive editors and reviewers!!! www.pnas.org/doi/10.1073/...
- Reposted by Joe WanfordDifferential targeting of human pyroptotic Caspase-5 and Caspase-4 by Shigella OspC2 and OspC3 biorxiv.org/content/10.64898/20…
- Reposted by Joe WanfordThrilled to share our latest paper on antibiotic treatment failure of Klebsiella pneumoniae liver abscesses www.pnas.org/doi/full/10.... @drwalkermsbanta.bsky.social
- Reposted by Joe WanfordHuge preprint if you are interested in bacterial strain taxonomy! The why and how of cgMLST LIN codes: An extensively revised and expanded version doi.org/10.1101/2024... I will summarize it for you in this thread 👇
- Reposted by Joe WanfordHot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/ www.science.org/doi/10.1126/...
- Reposted by Joe Wanford#AMR #Klebsiella cause >100,000 neonatal deaths globally each year. Our new preprint shows more than half of #Klebsiella pneumoniae neonatal sepsis cases in African and South Asian are nosocomial, acquired through transmission in neonatal units. #WAAW doi.org/10.1101/2025...
- Reposted by Joe Wanford[Not loaded yet]
- Reposted by Joe WanfordOut recently in Nature Microbiology👇 www.nature.com/articles/s41...
- Reposted by Joe Wanford[Not loaded yet]
- Reposted by Joe WanfordEnhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei @sydneylmiles.bsky.social @katholt.bsky.social 🙏to transformative collaborative effort www.nature.com/articles/s41...
- Great opportunity in a great lab!
- Job opportunity in my lab! We're looking for a post-doc to come join us for an exciting project exploring the evolution of #AMR and #hypervirulence in #klebsiella. Please share!! @unibirmingham.bsky.social Details: www.jobs.ac.uk/job/DOV067/r...
- 🎉 Delighted to share the first pre-print from my lab where we demonstrate that intergenic DNA repeats mediate phase variation of the mucoid phenotype in hypervirulent Klebsiella pneumoniae: www.biorxiv.org/content/10.1... #klebclub
- Reposted by Joe WanfordHow complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes? That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus. The paper: www.biorxiv.org/content/10.1... Thread👇
- 🚨 Job alert 🚨 I’m recruiting two postdoctoral research associates to join my lab at KCL to study how #Klebsiella pneumoniae regulates virulence factor expression during infection! #klebclub Mol Micro: tinyurl.com/mtrwtx5e Infection: tinyurl.com/2s3u8ca2 Deadline: 21st September.
- Now that it’s official, I’m delighted to announce I’ve been awarded a Wellcome Trust Career Development Award to fund my lab’s work on K. pneumoniae pathogenesis for the next 8 years! Very grateful to many fantastic mentors and collaborators who’ve helped throughout this process.
- Reposted by Joe WanfordDelighted our study (7+ years in the making) is out today in Nature. In a nutshell, 48 hours of antibiotics in week 1 led to impaired vaccine responses up to 15 months later in infants. We show (in-vivo) a probiotic can fix it #microbiome #science #immunology www.nature.com/articles/s41...
- Reposted by Joe WanfordI am recruiting a research assistant. Please send to anyone you know who is interested in gaining more lab experience in host:pathogen interactions of bacterial infections. www.jobs.cam.ac.uk/job/50738/
- Reposted by Joe WanfordOUT NOW: Inducible transposon mutagenesis identifies bacterial fitness determinants during infection in mice #microsky 🧪 www.nature.com/articles/s41...
- Reposted by Joe Wanford[Not loaded yet]
- Reposted by Joe WanfordI am very excited to share our latest publication on the effect of systemic #endotoxin on intestinal #microbiota spearheaded by the brilliant Sanne Kroon at the Hardt lab @eth-dbiol.bsky.social @ethzurich.bsky.social @naturecomms.bsky.social 👉🏼 rdcu.be/eelLn
- 🚨 Join us at King's College London for all things cellular microbiology! Super friendly meeting with cool science and great opportunity for ECRs to present their work!
- Reposted by Joe Wanford[Not loaded yet]
- Reposted by Joe Wanford
[Not loaded yet] - Reposted by Joe WanfordNature research paper: Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses go.nature.com/3XmyOPD
- Reposted by Joe Wanford[Not loaded yet]
- Reposted by Joe WanfordBase-modified nucleotides mediate immune signaling in bacteria www.science.org/doi/abs/10.1... #jcampubs
- Reposted by Joe Wanford[Not loaded yet]
- Reposted by Joe WanfordDelighted to share our new study. A collaboration with the Thurlow lab. Antibiotic resistance rapidly emerges and thrives in diabetic mice. A worrying coming together of two major and growing health problems worldwide www.science.org/doi/10.1126/...
- Reposted by Joe Wanford[Not loaded yet]
- Reposted by Joe WanfordSuper excited to finally present the preprint to accompany Kaptive 3 which we released last year! Big thanks to coauthors @kelwyres.bsky.social, @katholt.bsky.social, @genomarit.bsky.social and Iren Löhr. Here's what we did to improve in silico antigen typing 👇🧵 www.biorxiv.org/content/10.1...
- Reposted by Joe WanfordNew pre print! We establish an ex vivo blood vessel model to investigate the effect of infection on vascular physiology in real time. We show Klebsiella inhibits vasodilation in a T6SS-dependent manner by targeting eNOs. Superb work by @safimicro.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Joe Wanford[Not loaded yet]
- Reposted by Joe WanfordLast work from the lab in @cp-trendsmicrobiol.bsky.social ! We review the most recent evidence on the strategies deployed by Klebsiella to counteract host defences. www.sciencedirect.com/science/arti... The co-evolution with the immune system has taught the bug a couple of tricks!!!
