Jose Bengoechea
Working on innate immunity & host-pathogen interactions. Finding new ways to treat infections by antibiotic resistant bacteria. All views are my own.
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- Milestone of the lab...10000 strains in our collection!
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- For anyone interested in doing a PhD at the interface of microbiology and immunology focusing on how AMR pathogens subvert host defenses...you may consider applying to our MRC LID DTP project in which we will explore how Klebsiella hijacks the immune checkpoint PD-L1 mrc-lid.lshtm.ac.uk/apply/
- Reposted by Jose BengoecheaSo happy to share this! Bacteriocins were first discovered over 100 years ago, but what do they actually do? We look at >1000 bacteriocin plasmids and find links to virulence and antimicrobial resistance, and frequent bacteriocin sharing in Enterobacteriaceae. www.nature.com/articles/s41...
- Reposted by Jose BengoecheaGovernment has published one of those quiet but important documents that might get overlooked as it is not 'newsy'. The headline finding is that £1 of public R&D investment generates £8 in net economic benefits for the UK over the long term www.gov.uk/government/p...
- Reposted by Jose BengoecheaWhat makes PhD students happy? Good supervision www.nature.com/articles/d41...
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- Reposted by Jose BengoecheaEnhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei @sydneylmiles.bsky.social @katholt.bsky.social 🙏to transformative collaborative effort www.nature.com/articles/s41...
- Reposted by Jose BengoecheaNew paper with my (amazing) friend and mentor @jrpenades.bsky.social Really looking forward to see what plasmid aficionados think of this one!! With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others www.cell.com/cell-reports...
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- Reposted by Jose Bengoechea𝘒𝘭𝘦𝘣𝘴𝘪𝘦𝘭𝘭𝘢 𝘱𝘯𝘦𝘶𝘮𝘰𝘯𝘪𝘢𝘦 is a Gram-negative, non-motile, straight rod-shaped bacterium that can divide rapidly, with some strains having a median doubling time of < 30 min, forming biofilms that interfere with both antibiotic and immune clearance
- Reposted by Jose BengoecheaWhat an incredible week for @julielebris.bsky.social with one published ms in @asm.org #mBio on #capsule phenotypic heterogeneity & a preprint on the modular evolution of a highly exchangeable locus ⏩️capsule 😅 All her hard work is paying off! #ProudPI #microsky @klebclub.bsky.social Check her 🧵👇🏻
- How complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes? That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus. The paper: www.biorxiv.org/content/10.1... Thread👇
- Cool work Lindsay, congrats.
- Excited to share our @cp-cellhostmicrobe.bsky.social led by Magda showing how Bif has co-evolved with different animal hosts 🐒🐭🐷🐦 Key takeaways: 🔹 Host ancestry + diet shape Bif evolution 🔹 Mammals enriched for carb-busting enzymes 🔹 Untapped diversity in non-human hosts = new probiotic potential
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- Reposted by Jose BengoecheaA good way to think about institutional research culture!
- Good opportunity here to work with a super talented new PI.
- 🚨 Job alert 🚨 I’m recruiting two postdoctoral research associates to join my lab at KCL to study how #Klebsiella pneumoniae regulates virulence factor expression during infection! #klebclub Mol Micro: tinyurl.com/mtrwtx5e Infection: tinyurl.com/2s3u8ca2 Deadline: 21st September.
- Reposted by Jose BengoecheaMaybe I am being grumpy, but can people please stop using poorly curated databases of antibiotic resistance genes (I am looking at you, DeepARG) on shotgun metagenomic data and then present these results without any reflection on their validity, or shortcomings of databases?
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- Reposted by Jose BengoecheaThere are half a million cases of invasive non-Typhoidal Salmonella (iNTS) every year and while you might know S. Typhimurim and Enteritidis, you may not have heard of S. Panama 💩 🩸 🧫 💊 Check out our latest in @lancetmicrobe.bsky.social doi.org/10.1016/j.la... and the 🧵 below to find out more 1/n
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- Reposted by Jose BengoecheaJournal of Cell Science is published by a not-for-profit charitable organisation (@biologists.bsky.social) that exists to benefit science, not shareholders. We provide Travelling Fellowships, Training Grants, support for ECRs and more. For details, visit: journals.biologists.com/jcs/pages/re...
- Reposted by Jose BengoecheaIt's seem like arginine is emerging as a major host cue. So we wrote an IAI minireview on how arginine levels vary between host tissues and affect microbial behavior. The review is online today! journals.asm.org/doi/epdf/10.... @brookeeryan3.bsky.social #microsky
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- Reposted by Jose Bengoechea🚨🚨New paper out in @natcomms.nature.com!! Come for the first large-scale analysis of plasmid copy number across species, stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬 👉 www.nature.com/articles/s41...
- Reposted by Jose Bengoechea💥 Very excited to share this review in Nature Reviews Microbiology. Contributing to this review with Val, Digby and Amy was an enlightening experience! Hope people in the community find it useful- we managed to cite around 200 papers... www.nature.com/articles/s41... www.nature.com/articles/s41...
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- www.biorxiv.org/content/10.1.... New pre-print of the lab in which we dive deep into Klebsiella-macrophage interface. High structural resolution of the lipid A produced by Klebsiella within the Klebsiella containing vacuole governed bt TLR4 signaling. Superb job led PhD student Toby Bartholomew
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- Reposted by Jose BengoecheaExcited to share the first beta release of AMRrules at #ABPHM! (Poster 42 tonight) interpretamr.github.io/AMRrules
- Indeed he looks the same as 15 years ago!
- Reposted by Jose Bengoechea🚨New publication🚨 We show that K. Pneumoniae bacteriophages can be incorporated into alginate to create an antibiofilm matrix effective against clinical K. pneumoniae strains academic.oup.com/jambio/artic...
- Bacteriophage therapy for MDR infections. www.jci.org/articles/vie...
- Delighted to share our last pre print -this one close to my heart- We set to define the rules of lipid A associated with virulence by interrogating the genus Yersinia. www.biorxiv.org/content/10.1...
- Good to be back to Belfast!
- Reposted by Jose BengoecheaLandmark paper claxon! 'Evaluating the economic and health impact of proactive genomic epidemiology in a hospital setting' www.medrxiv.org/content/10.1... Significant savings associated with proactive genomic epidemiology.
- Somewhat unexpected that no one thought about this before...time is important for plasmid conjugation! journals.plos.org/plosgenetics...
- Reposted by Jose BengoecheaNew mechanism of gene transfer! With @tcostalab.bsky.social @imperialcollegeldn.bsky.social, we discovered that cf-PICIs form tail-less elements that, once released, spread among different bacterial species by hijacking tails from various phages. More exciting news soon! shorturl.at/kRJqE
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- New pre print! We establish an ex vivo blood vessel model to investigate the effect of infection on vascular physiology in real time. We show Klebsiella inhibits vasodilation in a T6SS-dependent manner by targeting eNOs. Superb work by @safimicro.bsky.social www.biorxiv.org/content/10.1...
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- Last work from the lab in @cp-trendsmicrobiol.bsky.social ! We review the most recent evidence on the strategies deployed by Klebsiella to counteract host defences. www.sciencedirect.com/science/arti... The co-evolution with the immune system has taught the bug a couple of tricks!!!
- Reposted by Jose BengoecheaMore than 40 percent of #postdocs leave academia. Those who landed a coveted faculty position were more likely to have had a highly cited paper, changed their research topic between their #PhD and postdoc, or moved abroad after receiving their doctorate. www.pnas.org/doi/10.1073/... @pnas.org
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- Reposted by Jose Bengoechea1/ 🚨 New preprint alert! 🚨 We’re thrilled to share our latest work exploring microbiome & genomic #Bifidobacterium co-evolutionary & functional signatures across diverse animal hosts. This has been a long time coming, & huge credit to Magda for her incredible hard work as first author! 🐾✨👇
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- Microbiome and depression www.cell.com/trends/molec...
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- Claim shown in Málaga....
- Taken days off with family to re charge batteries for 2025. Wish you all the best for the New Year. One day at a time, enjoying what we do to make a difference and helping others to achieve their best. Wish you all to fulfill your goals while putting a smile in others. Cheers.
- Reposted by Jose Bengoecheawww.nature.com/articles/s41... New paper out!!
- Nice work here that should help to advance protein function studies. Congrats Adam and the rest of the team.
- Fun Sunday evening...go Belfast Giants
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- Getting ready for traditional lab secret Santa
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- Reposted by Jose BengoecheaCrazy stuff in PNAS dental plaque bacterium 𝘊𝘰𝘳𝘺𝘯𝘦𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘮𝘢𝘵𝘳𝘶𝘤𝘩𝘰𝘵𝘪𝘪 can divide into an unprecedented 14 daughter cells at once—then each daughter cell starts growing immediately in a rare process called multiple fission, achieving 0.5 mm per day of expansion www.snexplores.org/article/bact...
- Reposted by Jose BengoecheaHot off the press - some light reading on Shigella sonnei! 🧪🧫🧬 With @ksbakes.bsky.social @yekwah.bsky.social @sydneylmiles.bsky.social @sergemostowylab.bsky.social @lshtmamrcentre.bsky.social and a bunch of others not yet on bluesky rdcu.be/d1EAF
- Reposted by Jose BengoecheaJOB CLAXON! I am recruiting a post-doctoral researcher on a BBSRC-funded project (36 months) on the genetics and functional genomics of vancomycin resistance in enterococci. Further details here: edzz.fa.em3.oraclecloud.com/hcmUI/Candid... Please DM or email me if you want to discuss this post.
