Vicky Lioy
Team leader @i2bcparissaclay.bsky.social #GenomeBiologyI2BC. Interested in bacterial chromosome and chromatin organization.
I2BC Science: scoop.it/u/institut-de-biolo…
- Reposted by Vicky LioyInstitut Pasteur (@pasteur.fr) is recruiting new young PIs to open new groups in the Institute. Deadline is February 9th! Don't miss the opportunity!
- Reposted by Vicky Lioy
I am very pleased to share that our database of prokaryotic and viral histones, ProHistoneDB, is now available online at prohistonedb.org. Please also see the accompanying article in J Mol Biol: doi.org/10.1016/j.jm... - Reposted by Vicky LioyBacteria are amazing! The abundant Dps protein binds and protects DNA in stationary-phase cells with minimal effect on chromosome accessibility, dynamics, and organization. Now in NAR doi.org/10.1093/nar/...; I'm really proud of our multidisciplinary team led by Lauren, Lindsay, and Xiaofeng, et al.
- Reposted by Vicky LioyFresh news on de novo genes! Happy to present our latest work published in Nature communications: www.nature.com/articles/s41... Keywords not in specific order: intergenic ORFs, de novo genes, GC content, foldability, genetic code, ancestral sequence reconstruction and more :)
- Le CNRS met en avant notre article publié dans @natcomms.nature.com Un grand merci à toutes et tous pour ce beau projet mené en collaboration avec #MKortebi @mickaelbourge.bsky.social @imagerie-gif.bsky.social #NGSFacilityI2BC, #E.vanDijk, @bury-mone.bsky.social, #CDorman et #FBoccard
- #ResultatScientifique🔎| Les gènes de virulence de Salmonella réorganisent localement la chromatine bactérienne, limitant le coût cellulaire et reliant structure 3D du génome et pathogénicité 🧬 ✍️ @vslioy.bsky.social 📕 @natcomms.nature.com | buff.ly/kT86ICN
- Reposted by Vicky LioyAfter 4 years of joint effort of my Lab and Dr. Llorente Team we took for first time SCRaMbLE to a bacterial system! This allowed us to massively reordered the main chromosome of Vibrio natriegens! biorxiv.org/content/10.6... Here's a 🧵
- Reposted by Vicky LioySMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out! www.biorxiv.org/content/10.1...
- White start to the year. Happy 2026 to everyone! @i2bcparissaclay.bsky.social
- Today was the last scientific council of #GenomeBiologyi2bc. Thank you @betermieri2bc.bsky.social, #Julie_Soutourina and @phbouloc.bsky.social , for your support and for creating such a great scientific environment.
- And all the best to the new direction of the department, @onamy.bsky.social @anne-lopes.bsky.social @daannoordermeerlab.bsky.social. I’m sure many scientific adventures are yet to come!
- Nos travaux de recherche mis en avant dans Le Journal du CNRS !😀 @i2bcparissaclay.bsky.social
- 🦠 Comment Salmonella déclenche-t-elle l’infection ? Le projet SaDi, mené à l'I2BC, révèle que l’architecture 3D de son génome orchestre l’activation des gènes de virulence. ✅ Une piste prometteuse pour déjouer l’antibiorésistance et l'infection. ▶️ lejournal.cnrs.fr/nos-blogs/fo...
- Open FSEP position in our team 📣 Nous recrutons un/e Ingénieur/e d’étude en biologie. Profil : être titulaire d’un poste permanent au CNRS (IE) et avoir envie d’étudier la chromatine bactérienne 😉 Date limite : jeudi 15 janvier. Détails et candidature ici : mobiliteinterne.cnrs.fr/ords/afip/ow...
- What a wonderful week in Japan! 🇯🇵 Many thanks to Kazutoshi Kasho and Prof. Oshima for inviting me to #MBSJ2025. Special thanks to @naomichitakemata.bsky.social and Shogo Ozaki for organising such a great satellite symposium. It was truly a pleasure discussing science with all of you.
- Reposted by Vicky LioyNew exciting work on genome segregation in Haloferax by @premrajka.bsky.social and @bramkamplab.bsky.social group. 🧬<>🧬
- Equipositioning of Chromosomes in the Polyploid Archaeon Haloferax volcanii by HpaAB biorxiv.org/content/10.1101/202…
- Reposted by Vicky Lioy📢 Interested in #chromosomes 🧬 & #archaea thriving at the edge of life? PhD project in York,UK on how archaea pass on their genome to daughter cells.Friendly supervisors: me, @steve-quinn-lab.bsky.social & @georgerheath.bsky.social www.findaphd.com/phds/project... 📅 January 7, 2026 Please RP🙏thx!
- Reposted by Vicky LioyIT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
- 🎉🥳👏Congratulations to Olivier and to the consortium. Excellent results will come to light soon in the #GenomeBiologyI2BC Department.
- I am very proud to announce that our team has received an ERC synergy grant from @erc.europa.eu. A wonderful recognition of a truly collaborative effort with friends (Julius Lukes, Leos Valasek and Mark Osborn). Excited to begin this journey at @i2bcparissaclay.bsky.social @cnrs.fr
- Reposted by Vicky Lioy🚨 Another funded PhD alert🚨 We are recruiting again! For a PhD student to start with us in the @langridgelab.bsky.social October 2026 - please share 👀 If you are interested in foodborne pathogens, public health and phage, look no further 🦠🏥🧬 ➡️ tinyurl.com/3zvavp2t ⬅️ Apply by 6 Jan 2026 🗓️
- #qed seems to be a new AI tool that could change the way we review (and write!) papers. Let’s try it!
- Reposted by Vicky LioyNucleoid structure and dynamics influence natural chromosomal transformation in Bacillus subtilis: the role of EbfC url: academic.oup.com/nar/article/...
- Another new team at #GenomeBiologyI2BC. Congratulations @cecilecourret.bsky.social
- I'm thrilled to announce that I’m opening my own research team in the Department of Genome Biology at I2BC @i2bcparissaclay.bsky.social ! #ATIP-Avenir Very excited to start this new adventure! www.i2bc.paris-saclay.fr/equipe-intra...
- Kicking off day two at the Spatial Organization of Biological Functions meeting at ICTS Bangalore! The first day was fascinating! #SOBF2025
- Reposted by Vicky LioyHow do SMC complexes load onto DNA to get ready for loop extrusion? @roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️. Check out the new paper: www.cell.com/molecular-ce...
- Reposted by Vicky Lioy🚨 First pre-print from my team !! TL;DR: presence of polymorphism (sequence differences between the homologous chromosomes) can *increase* the local rate of recombination in Arabidopsis thaliana, turning cold regions of the genome hot (purple v. grey) !
- Reposted by Vicky Lioy📝New preprint! #MicroSky 🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy. 🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation. www.biorxiv.org/content/10.1...
- Reposted by Vicky LioyThe @yorkmuseumstrust.bsky.social's Hospitium was such a lovely location for the @biochemsoc.bsky.social #BioPhyChrom2025 conference dinner. Gorgeous gardens, fabulous food & captivating conversations Thank you to the organisers for creating a great program & friendly interdisciplinary environment
- This also happened at #BioPhyChrom2025, congratulations @ceesdekker.bsky.social @danielabarilla.bsky.social @damelab.bsky.social @graingerlab.bsky.social
- Reposted by Vicky LioyNew paper! We generated and/or (re)analyzed ~100 #metagenomics Hi-C datasets to provide a comprehensive analysis of bacterial and viral metagenomes across VERY different environments. Congratulations to all authors especially Amaury Bignaud and @mmarbout.bsky.social for the huge work! #metaHiC
- You like phages ? In this publication, we use metaHiC and our new version of the MetaTOR pipeline to challenge the traditional view of phages with a narrow host range. @rkoszul.bsky.social @natmicrobiol.nature.com @cnrs.fr @institutpasteur.bsky.social www.nature.com/articles/s41...
- Reposted by Vicky LioyThat’s a wrap for The Biology and Physics of Prokaryotic Chromosomes VII 2025. A big thank you to all those who attended 🧪 #BioPhyChrom2025 #BiochemEvents
- #Biophychrom2025 is over, but we spent four exciting days discussing the biology and physics of prokaryotic chromosomes. Congratulations to all the attendees for making this conference a success. @biochemsoc.bsky.social @danielabarilla.bsky.social @graingerlab.bsky.social @damelab.bsky.social
- Reposted by Vicky Lioy#BioPhyChrom25 gala dinner at the 14th century #Hospitium venue in York, and @agnesnoy.bsky.social talk. Lots of discussion and ideas for BioPhyChrom2027… Great vibes and atmosphere! @biophychrom.bsky.social @damelab.bsky.social @vslioy.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social 🧬
- Reposted by Vicky LioyWell that's a wrap @biochemsoc.bsky.social #BioPhyChrom2025 thank you to the organisers & everyone here for contributing to a wonderful week. Looking forward to hopefully seeing you all again in Paris 🇫🇷 @danielabarilla.bsky.social @damelab.bsky.social @graingerlab.bsky.social @vslioy.bsky.social
- Reposted by Vicky LioyWe have been hearing great things about @biochemsoc.bsky.social #BioPhyChrom2025 & it looks like our Emma is having fun.. maybe too much?😉 Don't worry when she's back she will be writing a paper on this work showing that genomic rearrangement can impact #virulence & #AMR. Find Poster 9 to hear more
- What a great 1st session @biochemsoc.bsky.social #BioPhyChrom2025. A great mix of talks & discussion points from all speakers I am looking forward to sharing my work showing that genome structure variation can influence #virulence & #AMR. Come see me at poster 009
- Reposted by Vicky Lioy@danielabarilla.bsky.social kicking off #BioPhyChrom2025 - a fantastic turn out too...
- Reposted by Vicky LioyWho's ready for an exciting week ahead in York @biochemsoc.bsky.social's Biology & physics of Prokaroytic Chromosomes?! #BioPhyChrom2025
- Reposted by Vicky LioyA big welcome to the attendees of The Biology and Physics of Prokaryotic Chromosomes VII. We’re looking forward to bringing together the community in York #BiochemEvent #BioPhyChrom2025
- Reposted by Vicky LioyWhat a great 1st session @biochemsoc.bsky.social #BioPhyChrom2025. A great mix of talks & discussion points from all speakers I am looking forward to sharing my work showing that genome structure variation can influence #virulence & #AMR. Come see me at poster 009
- Finally in York! Tomorrow is D-Day #BioPhyChrom2025 kicks off with a great program and posters! @danielabarilla.bsky.social @damelab.bsky.social @graingerlab.bsky.social
- Reposted by Vicky LioyThis week we are celebrating the 10th anniversary of the I2BC — very proud of what we have accomplished together! www.i2bc.paris-saclay.fr
- UK mode ON 🇬🇧 #BioPhyChrom2025 ahead! First stop @quadraminstitute.bsky.social for some Salmonella chromatin chats with @emmabeansworth.bsky.social & @langridgelab.bsky.social
- Reposted by Vicky LioyThe countdown for #BioPhyChrom2025 is nearly over: -2 days to go… What a fête of chromosome biology & physics!🧬 Safe journey everyone! ✈️🚂 @vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social www.eventsforce.net/biochemsoc/f...
- 🚨 Open position: A 2-year engineer/postdoc position will be available in Julie Soutourina’s group at #GenomeBiologyI2BC. The project focuses on Mediatorpathies, rare neurodevelopmental diseases, using yeast and human cell models with genomics and bioinformatics approaches. More info and contact 👇
- Celebrating the 10 years of the @i2bcparissaclay.bsky.social with an excellent program of talks! Happy birthday I2BC !!🎊 🎂
- Looking forward to this great meeting and glad to have the chance to share our work on #BacterialChromatin 🧫🧬
- Please re-post: Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo... Abstract deadline: 30 September
- Next week, Biophychrom is happening and there’s still time to join us! 👇🏻
- One week to go for The Biology & Physics of Chromosomes VII, but there is still time to register! Join us! 🧬🧬🧬 @biophychrom.bsky.social @biochemsoc.bsky.social @vslioy.bsky.social @graingerlab.bsky.social @damelab.bsky.social
- Reposted by Vicky LioyOur Wadjet-II paper by @roisnehamelinf.bsky.social is out in polished form: www.cell.com/structure/fu... With a great preview by @kevincorbett.bsky.social & @amardeeep.bsky.social highlighting the potential of Wadjets: Wadjet—Keeping a watchful eye on circular DNA. www.cell.com/structure/fu...
- Happy to share the beautiful structure of a Wadjet SMC complex by @roisnehamelinf.bsky.social, with support from the DCI and @drhonsworth.bsky.social ! This is a type II Wadjet with unique characteristics including a tandem KITE subunit, distinct coiled coil architecture and a deviant hinge.
- Reposted by Vicky LioyFor those who love bacterial replicons, The ultimate review, from our lab, signed by the master of their evolution. @val-meve.bsky.social www.sciencedirect.com/science/arti...
- Reposted by Vicky Lioy🎓 My team is seeking a PhD student in Biochemistry & Cell Biology at I2BC, Paris-Saclay! 🔬 Study cytoskeletal signaling in collective cell migration 🌍 Fully funded, 3 yrs | 📍 Gif-sur-Yvette, France 🗓️ Apply by Aug 22 via the following link: emploi.cnrs.fr/Offres/Docto...
- Tomorrow is the last day!
- 📢 Dear lovers of prokaryotic chromosomes: Registration for the Biology & Physics of Chromosomes meeting has been extended until 7 August ⏳. Join us! @biophychrom.bsky.social @danielabarilla.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social #microsky
- Reposted by Vicky LioyA 2-year postdoc position in my lab, under the supervision of P-Alex Kaminski, on Z-DNA phages and the benefit given by ZTGC DNA and the replication machinery, with attempt to create a Z based minireplicon research.pasteur.fr/en/job/a-two...
- 📢 Dear lovers of prokaryotic chromosomes: Registration for the Biology & Physics of Chromosomes meeting has been extended until 7 August ⏳. Join us! @biophychrom.bsky.social @danielabarilla.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social #microsky
- Reposted by Vicky LioyChromosome enthusiasts, York is calling! Join us at The Biology & Physics of Chromosomes www.eventsforce.net/biochemsoc/f... Late breaking abstract deadline 📆 7 August @biophychrom.bsky.social @vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social #microsky
- Talk slots full but we can take late breaking poster abstracts until August 7th. Hope to see you in York to hear about your chromosome story 🧬🦠🧫 www.eventsforce.net/biochemsoc/f... @vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social
- Reposted by Vicky LioyA 2 yr postdoc position at the Bacterial Genome Plasticity Unit of the Institut Pasteur (Paris) led by @amazeld.bsky.social in collaboration with Pierre-Alexandre Kaminski, funded by the French National Research Agency 👇
- Reposted by Vicky LioyTalk slots full but we can take late breaking poster abstracts until August 7th. Hope to see you in York to hear about your chromosome story 🧬🦠🧫 www.eventsforce.net/biochemsoc/f... @vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social
- Reposted by Vicky LioyJust few days left to register for this chromosome biology fête! 🧬🧬🧬 ⏳📆 16 July www.eventsforce.net/biochemsoc/f... @vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social
- Reposted by Vicky LioyI am pleased to share our new review on the role of bacterial nucleoid-aasociated proteins in mediating responses to changes in environment. Important: some NAPs can directly ‘sense’ physico-chemical changes. www.sciencedirect.com/science/arti... @pingzhuangge.bsky.social
- ⏳ 🐤 Early bird deadline approaching soon ➡️ 16 July! Don’t miss out! Half of the talks will be selected from abstracts. Join us in York to talk about the Biology and Physics of Prokaryotic Chromosomes. @danielabarilla.bsky.social @damelab.bsky.social @graingerlab.bsky.social
- Reposted by Vicky LioyYork calling! 📣 🧬🧬🧬 Join us at www.biochemistry.org/events-and-t... ⏳⏰ Early bird deadline approaching soon, 16 July! Do not miss out! Half of the talks selected from abstracts. @damelab.bsky.social @vslioy.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social
- Reposted by Vicky LioyChromosome Enthusiasts, join us at The Biology & Physics of Prokaryotic Chromosomes 🧬! Friendly community, fantastic speakers line-up, grant writing session for ECRs. Early-bird deadline approaching soon. @damelab.bsky.social @vslioy.bsky.social @graingerlab.bsky.social @biophychrom.bsky.social
- Reposted by Vicky LioyNew tenure track assistant professor position in molecular microbiology in our department @dmf-unil.bsky.social @unil.bsky.social! We are casting a wide net for an experimental molecular microbiologist. Apply here: wwwfbm.unil.ch/releve/appli...
- Reposted by Vicky LioyJoin us in York for the Biology & Physics of Prokaryotic Chromosomes! 🧬 #Microsky #Archaeasky www.biochemistry.org/events-and-t... @biochemsoc.bsky.social @damelab.bsky.social @graingerlab.bsky.social @vslioy.bsky.social
- Last @i2bcparissaclay.bsky.social PhD day! I’m happy to discover the work of the future generation of researchers!
- Reposted by Vicky Lioy[Not loaded yet]
- Come on! You still have time to register!
- Join us in York for the Biology & Physics of Prokaryotic Chromosomes! 🧬 #Microsky #Archaeasky www.biochemistry.org/events-and-t... @biochemsoc.bsky.social @damelab.bsky.social @graingerlab.bsky.social @vslioy.bsky.social
- Reposted by Vicky LioyPleased to share a new preprint - a great collaboration with @jessicaandreani.bsky.social and the Guerois lab at I2BC, and the Radicella lab at the CEA. Using stuctural modelling, we reveal & validate a 3 protein complex involved in DNA import during transformation. www.biorxiv.org/content/10.1...
- Reposted by Vicky LioyNew postdoc position in our lab (2 y+): evolutionary genomics of integrons and MGEs with focus on vibrio-phage interactions. Great environment @pasteur.fr for science, career building. Super collaborators @celineloot.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social 3 weeks to apply!
- Reposted by Vicky LioyI was waiting two years to see this out!! The genomic location of bacterial genes is not random!!! Congratulation on the authors (Martin Lercher and Team!). www.science.org/doi/10.1126/...
- Reposted by Vicky LioyContrary to popular belief, what is important in science is as much its spirit as its product: it is as much the openmindedness, the primacy of criticism, the submission to the unforeseen, however upsetting, as the result, however new that may be. – Francois Jacob www.nature.com/articles/s41...
- Reposted by Vicky LioyA new publication from my lab a great work done with fantastic colleagues from #IGDR (Reynald Gillet’s team for all the cryoem work. pubmed.ncbi.nlm.nih.gov/40187343/
- Reposted by Vicky LioyDear Clostridia enthusiastics, Here is a reminder that Clostpath 14 (www.clostpath2025.conferences-pasteur.org/home) will be held at the institut Pasteur of Paris from September 1 to 4, 2025. Deadline for abstract submission is May 1. We are looking forward to welcome you.
- Another reason to join us at @biophychrom.bsky.social next September 2025! Registration is open!
- Reposted by Vicky Lioy#RésultatScientifique🔎 VIH : de nouvelles cibles pour l’immunité @onamy.bsky.social et ses collaborateurs révèlent que des antigènes du génome du VIH activent une forte réponse immunitaire, ouvrant de nouvelles pistes pour les vaccins ! 🧬
- We are very happy to share our latest preprint! 📣 H-NS is a xenogeneic silencer that prevents the costly expression of horizontally acquired genes. In Salmonella, H-NS silences several Pathogenicity Islands (SPIs), including SPI-1, which is essential for host invasion. 🧵⬇️
- SPI-1 genes show stochastic expression, making it challenging to study chromatin structure. To bypass this problem, we used functional genomics on sorted populations expressing SPI-1 or not.
- When SPI-1 is activated, H-NS occupancy is remodeled, creating a new chromatin landscape that, together with HilD, facilitates transcription and the formation of Transcription-Induced Domains (TIDs).
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View full threadI cannot finish this 🧵 without highlighting that this work wasdone by excellent postdoc, Mounia Kortebi, in collaboration with @mickaelbourge.bsky.social, @imagerie-gif.bsky.social, @bury-mone.bsky.social and many others not on Blueky
- Reposted by Vicky LioyProkaryotic genome enthusiasts, don’t forget to register for this excellent meeting
- Reposted by Vicky Lioy🇫🇷 Pour les francophones 🇫🇷 : un résumé accessible de notre récente étude publiée dans @pnas.org (www.pnas.org/doi/10.1073/...) par @cnrsbiologie.bsky.social . Merci de mettre en avant notre travail 🙏
- Reposted by Vicky LioyOur study on how TAD boundaries actively influence the neighboring domains published today in @pnas.org: www.pnas.org/doi/10.1073/... Exciting outcomes from this interdisciplinary genomics/biophysical modeling strategy. See the thread for the BioRxiv preprint for a summary of highlights.
- Boundaries between TADs often extend over considerable distance. But how variable is this width of boundaries? And does it matter? Find out in our new pre-print with the group of David Holcman. www.biorxiv.org/content/10.1...
