Olivier Namy 🧬🧪
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- Reposted by Olivier Namy 🧬🧪Ribosome collisions activate ZAK, influencing cell fate via p38 & JNK phosphorylation. Biochemistry & cryo-EM uncover distinct ZAK-ribosome interactions. PMID:41261136, Nature 2025, @Nature doi.org/10.1038/s41586-025-… #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
- Reposted by Olivier Namy 🧬🧪A (belated!) highlight from an excellent collaboration with @dunhamlab.bsky.social and #HouLabTJU. In this Nat Commun paper, we combine smFRET and cryo-EM to show how the tRNA modification m¹G37 stabilizes the reading frame—and what happens when it’s missing.
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- I am very pleased to share our latest article published in NAR Genomics and Bioinformatics. A collaborative effort with great colleagues from the I2BC NGS facility. thanks to @i2bcparissaclay.bsky.social for its financial support through epiRNA programs academic.oup.com/nargab/artic...
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- Reposted by Olivier Namy 🧬🧪Our new paper on DusB’s role in redox metabolism in V. cholerae is now out in @narjournal.bsky.social linking tRNAmodif enzymes and metabolic adaptation. Beyond RNA modification: a tRNA-modifying enzyme shaping oxidative stress resilience and metabolism in V. cholerae #rnasky #rnabiology 😊🦠💫
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- IsoNet2 determines cellular structures at submolecular resolution without averaging biorxiv.org/content/10.64898/20…
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- Reposted by Olivier Namy 🧬🧪Using "in extracto cryo-EM", we visualize ribosomes in mammalian lysates, including RRL. "Hibernating" ribosomes carry an extended set of proteins that protect functional centers. These include elongation factor eEF2, LARP1 implicated in mTOR signaling, eIF5A etc. www.biorxiv.org/content/10.1...
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- Waouh translational termination depends on circadian cycle!
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- I am very proud to announce that our team has received an ERC synergy grant from @erc.europa.eu. A wonderful recognition of a truly collaborative effort with friends (Julius Lukes, Leos Valasek and Mark Osborn). Excited to begin this journey at @i2bcparissaclay.bsky.social @cnrs.fr
- The newly announced ERC Synergy Grant includes research on: ✴️ genetic drug design ✴️ the Big Bang's first microseconds ✴️ crowd movement ✴️ nature-society interactions 👉 buff.ly/ZQhLp4h Congrats to the 66 awarded research teams! #FrontierResearch
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- Reposted by Olivier Namy 🧬🧪Excited to announce the YAK lab's first paper and the discovery of the FIRST human cellular PRF signal to give access to two overlapping open reading frames (science.org/doi/10.1126/...)! Before we dive in, the story actually begins in a Nature from 11 years ago
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- Probably one of the best European lab if you are interested in ribosome structure! Go go go
- We are hiring…position suitable for PhD student with interest in ribosomes, antibiotics and cryoEM… www.uni-hamburg.de/en/stellenan...
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- Reposted by Olivier Namy 🧬🧪Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...
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- Reposted by Olivier Namy 🧬🧪Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay
- Reposted by Olivier Namy 🧬🧪RIOK3 mediates the degradation of 40S ribosomes: Molecular Cell www.cell.com/molecular-ce...
- Reposted by Olivier Namy 🧬🧪The cover of the April issue of @cp-trendspharma.bsky.social. Gregory Howard and William Tansey review the current status, challenges, and future prospects of cancer treatments that target the ribosome. Aberrant ribosome production and function are hallmarks of cancer.
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- Congratulations to all the candidates who qualified for the #CNRS #CRCN competition in #Section21. Such brilliant science and incredible enthusiasm! Keep it up! c3n-cn.fr/2025/01/31/c...
- A new publication from my lab a great work done with fantastic colleagues from #IGDR (Reynald Gillet’s team for all the cryoem work. pubmed.ncbi.nlm.nih.gov/40187343/
- We performed a genetic screen to identify factor involved in the release of peptide from stalled #ribosomes. We identified a new mutation in #RQC2 factor.
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- Reposted by Olivier Namy 🧬🧪Out just now @naturecomms.bsky.social: using cryo-EM and cryo-electron tomography, we provide evidence that structurally heterogeneous ribosomes can cooperate in protein synthesis in bacterial cells: www.nature.com/articles/s41...
- Reposted by Olivier Namy 🧬🧪Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer. www.science.org/doi/10.1126/...
- Reposted by Olivier Namy 🧬🧪#RésultatScientifique🔎 VIH : de nouvelles cibles pour l’immunité @onamy.bsky.social et ses collaborateurs révèlent que des antigènes du génome du VIH activent une forte réponse immunitaire, ouvrant de nouvelles pistes pour les vaccins ! 🧬
- Reposted by Olivier Namy 🧬🧪"these approaches estimate the number of ribosomes on a transcript, the translation initiation rate, and the overall number of translation events before its decay, all in a genome-wide manner" #rnasky #ribosome www.nature.com/articles/s41...
- An important review we wrote with many colleagues! Important to read if you plan to use dual gene reporters! pubmed.ncbi.nlm.nih.gov/40033152/
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- Reposted by Olivier Namy 🧬🧪Don't miss the opportunity to come and work with us, as this is the last week to apply for our cell biology group leader position. Application deadline: Feb 28, 2025
- The Institute for Integrative Biology of the Cell (I2BC) is recruiting group leaders in cell biology. Don't miss the opportunity to start your team in the vibrant environment of Paris-Saclay University. Application deadline: Feb 28, 2025 www.i2bc.paris-saclay.fr @i2bcparissaclay.bsky.social
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- I am very pleased to share with you this fantastic work done in in collaboration with Arnaud Moris’steam. It has been a very pleasant collaboration and a fantastic project done at the #I2BC. #microproteine #riboseq #HIV www.nature.com/articles/s41...
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- A very interesting work from a great team! A must to read to understand stop codon readthrough. www.nature.com/articles/s41...
- Reposted by Olivier Namy 🧬🧪Congratulations to the Papenfort group and collaborators for this intriguing work uncovering the role of ProQ and its associated sRNAs in Vibrio motility! Grateful for the opportunity to be part of this discovery! academic.oup.com/nar/article-... #RNA #RIL-seq #Motility
- Reposted by Olivier Namy 🧬🧪Happy New Year 2025! I wish that this new year will be full of health, success, and happiness! 🎊@i2bcparissaclay.bsky.social
- Bonne année 2025 à tous! J’espère que cette nouvelle année vous apportera tout ce que vous en attendez avec de beaux résultats et de passionnantes discussions scientifiques go.bsky.app/Kjf7vCaat://did:plc:mznn4bpbhbayfliub3awbi4i/app.bsky.graph.starterpack/3lb5svzh5cf26
- Reposted by Olivier Namy 🧬🧪#RNAsky #ribosomes Take notice!
- The end of the year is a good time for a bit of appreciation: I work with a wonderful group of people. There will be some big lab news coming soon, but before then, here's a review we published earlier this year. academic.oup.com/narcancer/ar... #RNAbiology
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