Korostelev Lab
We are interested in life sciences, structural biology, translation, ribosomes, neurobiology and RNA therapeutics.
Location: RNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA, USA
umassmed.edu/korostelev-lab/
- GTPBP1 is a GTPase implicated in neurodevelopment. Our cryo-EM maps show GTPBP1 delivering tRNA to ribosome. Due to delayed GTPase dissociation, mRNA decoding is more stringent than with bona fide delivery factor eEF1A. Congrats to Denis Susorov and collab with Pestova lab! tinyurl.com/3smdvt3v
- Reposted by Korostelev LabCheck out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫 www.nature.com/articles/s41... A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
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- Using "in extracto cryo-EM", we visualize ribosomes in mammalian lysates, including RRL. "Hibernating" ribosomes carry an extended set of proteins that protect functional centers. These include elongation factor eEF2, LARP1 implicated in mTOR signaling, eIF5A etc. www.biorxiv.org/content/10.1...
- ROOL monomers entangle with other monomers via strand swapping to form octameric RNA nanocages. www.nature.com/articles/s41...
- With our @RTI-UMassChan.bsky.social colleagues Xiaobin Ling and Wenwen Fang, we report cryo-EM structures of enigmatic bacterial RNA nanocages made of ROOL RNAs. Octamers are held by "A-minor staples" and other interactions. Congrats Xiaobin, Dima et al! www.nature.com/articles/s41...
- Activation of Retron-Septu for antiphage defense. Congrats Tian-Min and all co-authors! www.science.org/doi/full/10....
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- Reposted by Korostelev LabTaking a cue from @cantlonlab.bsky.social, I have written an op-ed for my local newspaper about the impact of the NIH funding chaos. I'd appreciate it if you read and share. #NIH #Research #Science #Worcester www.telegram.com/story/opinio...
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- Reposted by Korostelev LabOur paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation www.cell.com/cell/fulltex...
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- Gabriel Demo and colleagues found how a small archaeal protein (aRDF) dimerizes 30S subunits to prevent ribosome formation:
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- Reposted by Korostelev LabOur latest work is out in Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 www.nature.com/articles/s41...
- RiSANA is online! We detail the Ribosome Stimulated Angiogenin Nuclease Assay (RiSANA) to explore: (a) whether Angiogenin is activated by bacterial 70S ribosomes; and (b) whether the closest homolog RNase 4 is stimulated by 80S: tinyurl.com/3fftczrw Congrats Emily Sholi and Anna Loveland!
- Reposted by Korostelev LabThis is a lovely piece about the 2024 Nobel Prize to Victor Ambros and Gary Ruvkun, written by Bruce Wightman, the first author of one of the prize-winning papers. It emphasizes the importance of fundamental research and the beauty of heterochronic genes. #Celegans #devbio 🧪🧬 doi.org/10.1242/dmm....
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- Reposted by Korostelev LabThe dark side of fluorescent protein tagging: the impact of protein tags on biomolecular condensation www.biorxiv.org/content/10.1...
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- Reposted by Korostelev LabHow long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...
