Alf Soler-Bistué 🦠🔬🧫
You may know @AlfMicrobioTweets from Twitter. PI at UNSAM 🇦🇷. Microbiology & genomics.
Microbial, growth, chromosome structure & evolution.
Vibrio, Bradyrhizobium (and Brucella) .
❤️🧪🦠Microbiology 🔬🧫❤️
Editor @ Curr. microbiology.
- After 4 years of joint effort of my Lab and Dr. Llorente Team we took for first time SCRaMbLE to a bacterial system! This allowed us to massively reordered the main chromosome of Vibrio natriegens! biorxiv.org/content/10.6... Here's a 🧵
- We placed 14 loxPsym sites to enable inversions, duplications, and translocations while preserving near‑wild‑type fitness before rearrangement. Including essential genes allowed avoiding deletions.
- Old tools for new problems: how to get glyphosate resistant/degrading bacteria using Winogradsky columns... www.sciencedirect.com/science/arti...
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- Super honored to have contributed to this excellent Reviews article by @val-meve.bsky.social and @amazeld.bsky.social on how extrachromosomal replicons (secondary chromosomes, chromids, megaplasmids) emerge in bacteria! 🦠 🧫 www.sciencedirect.com/science/arti...
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- Great paper on replication dynamics in E. coli with more than one oriC. What would happen if we further add more oriCs?? frontiersin.org/journals/mic... Congrats Ole Skovgaad for this sound paper!!
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- Budget cuts do not curb our enthusiasm! Ian lab meeting today on Bradyrhizobium cell physiology! #LabMeetinDay
- Estas en 3-4° año de biotecnología o carreras afines? Estamos buscando un/a estudiante de @unsamoficial.bsky.social para incorporar al laboratorio y presentar a una beca de entrenamiento de la CIC PBA! Te interesa? Vení a trabajar con nosotros!! #UNSAM #Biotecnologia !!
- What a huge story!!! Integrons are page resistance genes carriers!!! Not just silent " long term memory" geneyic structures!! Congrats two all the team!!
- 🧪 Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉 Short 🧵 www.science.org/doi/10.1126/...
- Certainly a great place for a posdoctoral experience! Highly recommended!!!
- WARNING: We have a postdoc position to work on the follow-up of this work. If you're interested, the deadline is tomorrow !!! (but I'll wait a few more days for interested candidates). research.pasteur.fr/fr/job/postd...
- Huge story by @celineloot.bsky.social ! The chromosomal integrons are reservoirs of defense systems against Phages!
- Reposted by Alf Soler-Bistué 🦠🔬🧫🧪 Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉 Short 🧵 www.science.org/doi/10.1126/...
- Submitted! Fingers crossed!!
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- And its out! Last work of the lab: "Evolutionary Constraints on RNA Polymerase Gene Positioning in the Genome of Fast-Growing Bacteria." We show how the genomic location of RNA polymerase impacts cell physiology. www.biorxiv.org/cgi/content/...
- Bacteria harbour a single RNAP encoded by rpoBC genes. In fast-growers it is conserver close to oriC (bsky.app/profile/did:...). We relocated rpoBC (in red) to different locations within Vibrio cholerae genome:
- I was waiting two years to see this out!! The genomic location of bacterial genes is not random!!! Congratulation on the authors (Martin Lercher and Team!). www.science.org/doi/10.1126/...
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[Not loaded yet] - I was waiting two years to see this out!! The genomic location of bacterial genes is not random!!! Congratulation on the authors (Martin Lercher and Team!). www.science.org/doi/10.1126/...
- Almost 20 years ago @epcrocha.bsky.social Eduardo Rocha'steam discovered that transcription and translation related genes were biased towards replication origin in bacteria. onlinelibrary.wiley.com/doi/full/10....
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- Gran Curso de Biología Vegetal en Chile! Coordina el gran @estevezjosem.bsky.social
- Reposted by Alf Soler-Bistué 🦠🔬🧫Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to ML.Antibiotics@gmail.com. See lnkd.in/dVVk4N3s. #microsky
- Great Paper by @vslioy.bsky.social on genomic plasticity of salmonella pathogenicity islands: the link between chromosome 3D and their expression! Huge effort, great work! Here is the preprint! www.biorxiv.org/content/10.1...
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- Reposted by Alf Soler-Bistué 🦠🔬🧫⚠️ Job(s) alert! ⚠️ We are launching a new postdoctoral program in Systems Biology at IBFG. Join us! 👉 Several positions available with competitive work conditions for up to 4 years 📄 More info: jdiazc9.github.io/files/jobs/2...
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- A new Argentinean Society for General Microbiology (SAMiGe) Board starts. My new role is General secretary. We will do our best effort to promote fundamental microbiology in 🇦🇷 and the region in this challenging context!
- Reposted by Alf Soler-Bistué 🦠🔬🧫Out in NAR, AntiDefenseFinder & our "systematic" analysis of inhibitors of antiphage systems wt Bondy-Denomy lab led by @ftesson.bsky.social and E. Huiting. Not so "systematic" as very few known, fun stuff on MGE, antidefense islands and cool phages exaptations! academic.oup.com/nar/advance-...
- Reposted by Alf Soler-Bistué 🦠🔬🧫The Institut Pasteur is recruiting group leaders! Pasteur is an absolute incredible environment to start your lab. Surrounded by so many great scientists, in the beautiful city of Paris. Come eat 🥐 and conduct awesome science. Contact me if you want info ! research.pasteur.fr/en/call/call...
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- Reposted by Alf Soler-Bistué 🦠🔬🧫I wrote a little perspective piece www.cell.com/cell/fulltex... on this mind-blowing paper www.sciencedirect.com/science/arti... by @asanchezlab.bsky.social and colleagues.
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- Reposted by Alf Soler-Bistué 🦠🔬🧫Très honorée et émue de faire partie des 2 lauréats 2024 du prix Agnes Ullmann, pionnière de la recherche sur la régulation de l'expression des gènes des bactéries. Toute ma gratitude à l'Institut Pasteur, au comité de sélection, et toutes mes collaboratrices et collaborateurs x.com/institutpast...
- Reposted by Alf Soler-Bistué 🦠🔬🧫🚨We have a "Lead Researcher" position in my lab at @StJude 👉This position is stable and not dependent on external funding. 🗒️ Ideally, the candidate holds a PhD in Microbiology or related topic. See ad for job details and apply! Please kindly repost! talent.stjude.org/careers/jobs...
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