Aurele Piazza
CNRS group leader at ENS de Lyon studying DNA recombination and spatial genome organization.
ens-lyon.fr/LBMC/equipes/mecani…
- SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out! www.biorxiv.org/content/10.1...
- Great collaboration with the lab of @djost-physbiol.bsky.social!
- Reposted by Aurele PiazzaA cool genetic system to study site-pecific replication fork collapse and repair from the brilliant @winterhalterlab.bsky.social www.nature.com/articles/s41...
- Reposted by Aurele Piazza🚨Our work on the impact of DNA replication on 3D genome is out in Genome Biology: replication-dependent loop extrusion by sister-forks, wave of replication, no evidence for large-scale replication factory. Great collab with @aurelepiazza.bsky.social. More here: link.springer.com/article/10.1...
- 🚨 new preprint from the lab. Combining modeling, new Hi-C data in yeast and data analysis, our study offers new insights into the spatial and dynamic organization of chromatin during replication in eukaryotes. Check the tweetorial below ⬇️ www.biorxiv.org/content/10.1...
- Reposted by Aurele PiazzaThrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n www.science.org/doi/10.1126/...
- Reposted by Aurele PiazzaI am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉! Our study reveals how cohesin guides focused and accurate homology search. Read more 👉 www.science.org/doi/10.1126/... Follow along for key insights and updates! 🧵
- Reposted by Aurele PiazzaThe 21st Course on Epigenetics which will take place from March 25th to April 1st, 2026 at the Institut Curie (Paris). The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at: minilien.curie.fr/3avv47
- Reposted by Aurele PiazzaNature research paper: From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes go.nature.com/4nVsl9z
- Reposted by Aurele Piazzaexcellent read. www.embopress.org/doi/full/10....
- Reposted by Aurele PiazzaA three-year PhD position is available within the team, starting no later than October 2026, to decipher the molecular signatures of chromosomal instability in response to replication stress and how nuclear architecture shapes these signatures in yeast. Please RT. fr.scribd.com/document/934...
- Reposted by Aurele PiazzaHappy that the final version of our Lamassu work @yli18smc.bsky.social is now out: www.nature.com/articles/s41... Thanks again to our awesome collaborators @mblokesch.bsky.social and David and co and Mark Szczelkun and @steven-shaw.bsky.social and the DCI Lausanne @fbm-unil.bsky.social
- Glad to share the work of @yli18smc.bsky.social and co on Lamassu, a bacterial defense system related to Rad50/Mre11 (RM). While RM carefully trims DNA ends for repair, Lamassu chops up the host chromosome. Our study reveals how it is regulated to minimize damage, activating only during infection.
- Reposted by Aurele PiazzaNew preprint from the lab !! Loop extrusion may provide mechanical robustness to chromatin. Great work by Hossein Salari. @cnrs.fr @lbmcinlyon.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Aurele PiazzaPREACH! www.nature.com/articles/s41...
- A thought-provoking piece!
- Plot twist: homologous recombination actually promotes the development of cancer! This discussion has been started in the hope that it will be useful, see the link: doi.org/10.1038/s413...
- Reposted by Aurele Piazza🍽️🧬 How do diet and gut microbes shape fertility across generations? 🪱🔬 Our Laboratory at #InstitutPasteur is recruiting a PhD student to study epigenetic inheritance of fertility using C. elegans. Fully funded via the International PPU program. Apply now! 🌍 #PhDposition #Epigenetics #Inheritance
- 🎓 Applications for Institut Pasteur's PhD programs open Sept 1-Oct 20, 2025 for October 2026 entry. Apply to up to 4 projects across 6 programs: PPU, PPU-IMAGINE @institutimagine.bsky.social, PPU-@ox.ac.uk, PPU-EID @upcite.bsky.social & more 🧬 Register now ✍️ www.pasteur.fr/en/education...
- Reposted by Aurele PiazzaIs euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing. www.biorxiv.org/cgi/content/...
- Reposted by Aurele PiazzaOur paper is now out in Molecular Cell! Check the thread in this former post: www.cell.com/molecular-ce...
- Hi everyone! The latest method from the Whitehouse lab: PCP PCP uses a novel proximity barcoding strategy to simultaneously map 3D genome organization at various resolutions at the single molecule level: Out soon, check the updated BioRxiv – little thread: 1/11 www.biorxiv.org/content/10.1...
- Transcription and recombination are two universal DNA-dependent processes, but how they are coordinated remains largely unknown. Here we characterized transcription-recombination priority rules in yeast. 🧵 www.embopress.org/doi/full/10....
- We used a highly efficient DNA break induction system in budding yeast, and quantified D-loops (the earliest DNA joint molecule formed upon homology identification) formed at a donor whose transcriptional level could be manipulated. Transcription caused a massive drop of D-loops.
- This effect of transcription could be induced and repressed in minutes, suggesting it reflected a direct effect of RNA PolII passage. Indeed, secondary effect of transcription (RNA, RNA:DNA hybrids, nuclear relocalization, endogenous TFs, …) were not involved in D-loop suppression.
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View full threadShout-out to @ydjeghmoum.bsky.social who single-handedly led this beautiful work during her PhD! Thanks @erc.europa.eu and the FRM for funding this work.
- Reposted by Aurele PiazzaAre you ready for the 2nd half of 2025? Social DNAing is ready. Check out the speaker list and schedule! Sign up at www.cancer.columbia.edu/research/pro...
- Reposted by Aurele Piazza1/ Super excited to share my first preprint from @andersshansen.bsky.social Lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)
- How does replication shapes the 3D organization of chromosomes? Check out this new preprint from our colleagues @djost-physbiol.bsky.social that investigates this question using a full polymer model of the budding yeast genome + new S-phase Hi-C data. Congrats to the lead author Dario D'Asaro!
- 🚨 new preprint from the lab. Combining modeling, new Hi-C data in yeast and data analysis, our study offers new insights into the spatial and dynamic organization of chromatin during replication in eukaryotes. Check the tweetorial below ⬇️ www.biorxiv.org/content/10.1...
- Reposted by Aurele PiazzaCome start your lab in beautiful Strasbourg 🇫🇷 www.nature.com/naturecareer...
- Reposted by Aurele Piazza[This post could not be retrieved]
- Reposted by Aurele Piazza!! Postdoc position available to study homologous recombination in live cells through advanced microscopy analyses in a collaboration between our lab and Angela Taddei's lab, both at @institutcurie.bsky.social in Paris. Apply to : job-ref-ib8q3lnnxn@emploi.beetween.com
- Reposted by Aurele PiazzaHappy to share our latest pre-print! We solved the cryoEM structures of human DNA repair factor MRN bound to DNA and to TRF2. Main work of Yilan, Filiz @filizkuybu.bsky.social and Hengjun. Great collab within the @sfb1361.bsky.social and @genecenter-lmu.bsky.social 🧬🔨 www.biorxiv.org/content/10.1...
- Reposted by Aurele Piazza*Lyon* #StandUpForScience Place des Terreaux à 16h : Rassemblement. Cet événement est un acte de solidarité envers nos collègues américains. Ensemble, affirmons notre engagement en faveur d’une science indépendante, accessible à toutes et tous.
- Reposted by Aurele PiazzaOnce upon a time, in the late 1800s, people in Japan got really into breeding mice. Coloured mice. Patterned mice. Even mice that danced. They became known as Japanese Fancy Mice, and that caught the attention of researchers in Europe and America, who imported them for study. 2/n
- Reposted by Aurele PiazzaAre you curious about eukaryotic plasmids? PhD student Fabien Girard with Axel Cournac in the lab explore the positioning of plasmid 2u, one of these rare (known) episomes, in the budding yeast nucleus. The results were surprising. #plasmids #chromatin #3Dgenome www.embopress.org/doi/full/10....
- A completely mind-blowing mechanism at the organism structural level to limit mutation accumulation www.biorxiv.org/content/10.1...
- How do cells prioritize molecular machines working on DNA? With which functional consequences? Here bs-less Yasmina Djeghmoum discovered and characterized transcription-recombination priority rules, and their role in promoting genome maintenance. 🧵 www.biorxiv.org/content/10.1...
- We used a highly efficient DNA break induction system in budding yeast, and quantified D-loops (the earliest DNA joint molecule formed upon homology identification) formed at a donor whose transcriptional level could be manipulated. Transcription caused a massive drop of D-loops.
- This effect of transcription could be induced and reversed in minutes, suggesting it reflected a direct effect of RNA PolII passage. Indeed, secondary effect of transcription (RNA, RNA:DNA hybrids, nuclear relocalization, endogenous TFs, …) were not involved in D-loop suppression.
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View full threadYasmina will soon finish her PhD and be on the postdoc market: you know what you have to do! Many thanks to our funding source @erc.europa.eu for allowing us to carry out this work.
- Reposted by Aurele PiazzaCTCF stall DNA 🧬 loop ➰ extrusion by cohesin - but exactly how it pulls this off is a 'mechanistic mystery' (to cite @andersshansen.bsky.social, Nucleus, 2020). We just preprinted 📜 a new study @biorxivpreprint.bsky.social that provides some answers to this enigma: www.biorxiv.org/content/10.1...
- Reposted by Aurele PiazzaCentromere evolution isn't a sudden switch! Our study shows centromere transitions are a step-by-step process driven by a combination of drift and selection. Discover how the kinetochore interface shapes this gradual change in our new preprint 🥳 doi.org/10.1101/2025.01.16.633479 🧵(1/8)
- Reposted by Aurele Piazza📢The 2025 MAYosis webinar series will be held on consecutive Wednesdays, May 7-28, at 4 pm CET (7 am PST; 12 am JST) meiosis.cornell.edu/mayoss2025/ Apply to give a talk (deadline is March 8, trainees and junior faculty only): tinyurl.com/47k3cjpn Registration is free: tinyurl.com/39rs53yv
- Reposted by Aurele PiazzaBuilding on our discovery of #LesionSegregation, @mikespencerchapman.bsky.social and colleagues from @sangerinstitute.bsky.social find that some DNA lesions can persist in humans for months or years! "Prolonged persistence of mutagenic DNA lesions in somatic cells" www.nature.com/articles/s41...
- Reposted by Aurele PiazzaImportant independent calibration of Hi-C data: www.biorxiv.org/content/10.1...
- Reposted by Aurele PiazzaWe hope you all had fantastic holidays and are ready for 2025! The GIIN webinars will restart next Tuesday, January 14th, with exciting talks from @labthoma.bsky.social and @stesantaguida.bsky.social ! Follow the zoom link to join: uniroma1.zoom.us/j/95149984403
- Reposted by Aurele PiazzaIs chromatin ordered or disordered? It all depends on the linker DNA length. Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets
- Nucleosome Spacing Can Fine-Tune Higher Order Chromatin Assembly biorxiv.org/content/10.1101/202…
- Reposted by Aurele PiazzaEver wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of @jonmarkert.bsky.social! tinyurl.com/setd2
- Reposted by Aurele PiazzaRegistration now open for the 2025 EMBO workshop on Meiosis! June 22-26, 2025, Engelberg, Switzerland. Deadline for abstract submissions and registration is Feb 15th, 2025. Lots of speaker slots will be selected from abstracts, so apply now! meetings.embo.org/event/25-mei...
- Reposted by Aurele PiazzaDelighted to publish my new molecular animation: DNA Break Repair by Homologous Recombination youtu.be/Xe-83tBcxhs
- Reposted by Aurele PiazzaStarships: a new frontier for fungal biology www.cell.com/trends/genet... Gigantic transposons in fungi with a cool name
- Reposted by Aurele Piazza📢 Make your work FASTER and EASIER! Use AlphaBridge to analyze your AlphaFold results and receive a clear, easy-to-understand output—even for non-experts. ➡️ Let AlphaBridge help you accelerate your workflow! ❤️ Share and try it here: alpha-bridge.eu 👀Read more: www.biorxiv.org/content/10.1...
- We are so grateful for receiving an #ERCCoG to support our research on the mechanisms of DNA break repair in cells. A major thanks to present (and a few past) members of the lab and our many colleagues at lbmcinlyon.bsky.social and beyond who prepped us so hard. www.cnrs.fr/en/node/9347
