Charles Winterhalter
Wellcome Early-Career Fellow investigating novel DNA damage repair mechanisms in bacteria at Newcastle university (UK)
- Reposted by Charles Winterhalter
Dynamic DnaA–DnaB interactions at oriC coordinate the loading and coupled translocation of two DnaB helicases for bidirectional replication url: academic.oup.com/nar/article/... - Reposted by Charles WinterhalterPhD position available in our team to study how UPEC exploits metals to successfully colonise the host gut. Cool collaboration with @thecopperdoctor.bsky.social and @banzhaflab.bsky.social Please share and get in touch for more details
- Reposted by Charles Winterhalterwww.findaphd.com/phds/project... interested in bacterial antagonism? PhD opportunity in our team, see below. Please repost!
- E. coli is the leading bacterium causing death from AMR infections worldwide. If you'd like to explore approaches to exploit the DNA damage response as alternative antimicrobial, please apply to the following PhD studentship available in my lab starting October 2026: www.findaphd.com/phds/project...
- Beautiful work with big implications for the future of Cas9-type technologies www.nature.com/articles/s41...
- Recombinational repair is the major pathway required to reload the bacterial replicative helicase following introduction of single-strand DNA breaks. A great way to end the year! Big thank you to co-authors from the @heathmurraylab.bsky.social
- A cool genetic system to study site-pecific replication fork collapse and repair from the brilliant @winterhalterlab.bsky.social www.nature.com/articles/s41...
- Congratulations to Hannah and colleagues for depicting the consequences of DNA replication hyper-initiation in Gram-positive bacteria! @microbiologysociety.org www.microbiologyresearch.org/content/jour...
- Reposted by Charles WinterhalterNew cryo-EM/ET story - a brilliant collaboration with Sergey Melnikov's lab in Newcastle @sergeymelnikov.bsky.social and Stefan Pfeffer's lab in Heidelberg @pfeffercryolab.bsky.social. Great work in particular by Karla Helena-Bueno and @sophiekopetschke.bsky.social www.nature.com/articles/s41...
- Still time to apply and join my team on a fully funded PhD project looking at dynamics of the bacterial DNA damage response in live cells using genomics.
- Engineering anti-CRISPR/Cas systems to control the DNA damage response in live bacterial cells. Supervised by @winterhalterlab.bsky.social, @acdarby.bsky.social, and Katarzyna Mickiewicz. www.findaphd.com/phds/project...
- Reposted by Charles WinterhalterThis was a fantastic collaboration with our neighbors @mblokesch.bsky.social & David Adams and Mark Szczelkun and @steven-shaw.bsky.social in Bristol. Special thanks to the DCI for invaluable support with cryo-EM of a rather difficult target! @drhonsworth.bsky.social www.biorxiv.org/content/10.1...
