In our most recent work David Forrest has discovered a widespread mechanisms linking transcription initiation to DNA supercoiling...
www.nature.com/articles/s41...The bacterial RNA polymerase-associated CarD protein couples promoter activity to DNA supercoiling - Nature Communications
The transcription factor CarD facilitates the activation of transcription in many bacteria and in Rhodobacter sphaeroides, CarD compensates for suboptimal promoter DNA sequences. Here, the authors sho...
