Calum H. G. Johnston
CNRS researcher in the pneumococcal competence and transformation team in Toulouse.
Using molecular genetics and cell biology to study pneumococcal competence and transformation.
- Reposted by Calum H. G. JohnstonDelighted to share a new paper from our lab, a study led by Mathieu Bergé looking at how an endogenous toxin targets replication to induce competence in the pneumococcus. dx.plos.org/10.1371/jour...
- Reposted by Calum H. G. JohnstonA cool genetic system to study site-pecific replication fork collapse and repair from the brilliant @winterhalterlab.bsky.social www.nature.com/articles/s41...
- Reposted by Calum H. G. JohnstonNew pub. from the lab ! We discovered that potato tubers exert intense selective pressure during Dickeya solani infection, driving the rapid emergence of mutations in the sRNA ArcZ. These mutations lead to the appearance of "social cheaters" that sweep through the pop. in as few as 30 generations.
- Host infection selects for sRNA variants that drive bacterial social cheating biorxiv.org/content/10.64898/20…
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- Reposted by Calum H. G. JohnstonLe 1er janvier 2026, le CNRS coupera l’accès au Web of Science, Core Collection et Journal Citation Reports. Une nouvelle étape de sa politique en faveur de la science ouverte pour promouvoir des alternatives ouvertes, transparentes et responsables.
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- Reposted by Calum H. G. JohnstonNew paper alert 🚨 I am super happy about it, for many reasons! 👥 It was a great collaborative project with Calum @chgjohnston.bsky.social and J. Pablo Radicella, designed a long time ago (in the pre-AlphaFold era - can you imagine?) together with @polardlab.bsky.social and @raphguerois.bsky.social
- Pleased to share our recent article in PNAS - a collaboration with @jessicaandreani.bsky.social & Pablo Radicella, with important roles played by many members of each team. A tripartite protein complex promotes DNA transport during natural transformation in Firmicutes www.pnas.org/doi/10.1073/...
- Pleased to share our recent article in PNAS - a collaboration with @jessicaandreani.bsky.social & Pablo Radicella, with important roles played by many members of each team. A tripartite protein complex promotes DNA transport during natural transformation in Firmicutes www.pnas.org/doi/10.1073/...
- Reposted by Calum H. G. JohnstonCome and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces www.gla.ac.uk/postgraduate... please repost
- New paper from our lab up on Biorxiv, showing how a toxin targets replication to induce competence. 👇
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- For those who are interested in all things 'transformation', here is a link to registration for the 6th edition of the Zoom on Griffith's Legacy, the 4th and 5th June 2025. griffiths2025.sciencesconf.org It has been fun co-organising this with Luisa Hiller. We hope to see you there!
- Pleased to share a new preprint - a great collaboration with @jessicaandreani.bsky.social and the Guerois lab at I2BC, and the Radicella lab at the CEA. Using stuctural modelling, we reveal & validate a 3 protein complex involved in DNA import during transformation. www.biorxiv.org/content/10.1...
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