Erwan Gueguen
Molecular microbiology assistant-professor at University of Lyon. I tweet only about Science here.
I work on Pectobacteriaceae. I don't like bacteria that can't be genetically manipulated.
Lab website: sites.google.com/view/mtsb
- MSCA Postdoctoral Fellowship 2026 opportunity. Join my team at Lyon 1 University Claude Bernard to study functional genetics of plant pathogens. Full details are available in the attached document. Internal Deadline: June 15, 2026
- I find something amiss with this figure depicting the GAC system network in Pseudomonas aeruginosa published here: journals.asm.org/doi/10.1128/... Should the RsmA binding sites be represented as a double-stranded helix? 🤔 It’s confusing about what this protein actually does. Don't you think ?
- Nous recrutons un Maître ou une Maîtresse de conférences en bactériologie moléculaire pour notre équipe MTSB au laboratoire MAP à Lyon, France. Le poste combine recherche sur l'adaptation des bactéries phytopathogènes et enseignement en génétique microbienne. Notre team : sites.google.com/view/mtsb
- Travailler à Lyon, c'est profiter d'une qualité de vie reconnue, entre patrimoine de l'UNESCO et proximité des Alpes, sur un campus en bordure du parc de la Tête d'Or. Contactez-moi (Erwan Gueguen) pour + d'infos
- New pub. from the lab ! We discovered that potato tubers exert intense selective pressure during Dickeya solani infection, driving the rapid emergence of mutations in the sRNA ArcZ. These mutations lead to the appearance of "social cheaters" that sweep through the pop. in as few as 30 generations.
- Host infection selects for sRNA variants that drive bacterial social cheating biorxiv.org/content/10.64898/20…
- This study is the first to identify mutations in a small regulatory RNA as a driver of social cheating. By acting as a molecular rheostat, ArcZ remodeling uncouples virulence from antimicrobial production, allowing cheaters to exploit public goods for a competitive advantage.
- Reposted by Erwan GueguenMicrobes weaponizing secondary metabolites to make rivals vulnerable to phage attack 🧪🦠 www.nature.com/articles/s41...
- Reposted by Erwan Gueguen🏆 Institut Pasteur Canetti Prize 2025 awarded to Céline Loot for her innovative contributions to infectious disease research. This annual Institut Pasteur prize (€15K) honors scientific excellence, funded by the Canetti family legacy. Congratulations Céline 👏
- Reposted by Erwan Gueguen
- Reposted by Erwan GueguenLost Science is a new NYT series of accounts from scientists who have lost their jobs or funding. You can send your story to the Times here www.nytimes.com/2025/10/08/c...
- Reposted by Erwan GueguenHave you wondered if some E. clones are so successful because of their plasmids? www.biorxiv.org/content/10.1... A combination of bioinf and lab work showed that some plasmids have coexisted for centuries, and that a specific colicin gene is able to kill other clones paving their way for success!
- Reposted by Erwan GueguenHow do spontaneous mutations arise? In this latest #GENETICS review, Susan Lovett and @thalia.bsky.social provide a detailed overview of bacterial genetics experiments instrumental in understanding how genomes change. buff.ly/CXJnTqn
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- Reposted by Erwan GueguenQuite an interesting protein search AI model combining sequence, structure, and function text - faster and more accurate than similarity searches. Who has tried it🤩🙌? Only a few secs to search bacterial TFs and integrases #microsky 🧬🧪 www.nature.com/articles/s41...
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- Reposted by Erwan Gueguen#ResultatScientifique🔎| Des scientifiques ont révélé comment le plasmide pOXA-48 rend les bactéries ultra-résistantes aux antibiotiques 🦠 🤝 @cnrs.fr @mmsb-lyon.bsky.social @cnrs-rhoneauvergne.bsky.social ✍️ @sbigot.bsky.social 📕 @natcomms.nature.com | buff.ly/u3Cy4Db
- Reposted by Erwan Gueguen1. Kevin Gross and I just posted a new science-of-science preprint. This one explores the looming peer review crisis. As many of you know, it's becoming significantly more difficult for journal editors to find scholars willing to serve as peer reviewers for submitted manuscripts.
- Reposted by Erwan GueguenA bacterial host factor confines phage localization for excluding the infected compartment through cell division @cp-cellreports.bsky.social from Sigal Ben-Yehuda www.sciencedirect.com/science/arti...
- Reposted by Erwan GueguenToday in the journal Science: BioEmu from Microsoft Research AI for Science. This generative deep learning method emulates protein equilibrium ensembles – key for understanding protein function at scale. www.science.org/doi/10.1126/...
- Reposted by Erwan Gueguen@cnrsecologie.bsky.social regrette profondément l'adoption de cette loi à la vision court-termiste & ses conséquences graves sur l’environnement, qui méprise santé & bien-être de la population & le rôle des espèces sauvages dans la prod. agricole. La communauté scientifique n'a pas été entendue.
- Reposted by Erwan Gueguen🚨🚨New paper out in @natcomms.nature.com!! Come for the first large-scale analysis of plasmid copy number across species, stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬 👉 www.nature.com/articles/s41...
- Reposted by Erwan GueguenHarnessing Small RNAs as Synthetic Post-transcriptional Regulators in Bacteria pubs.acs.org/doi/10.1021/...
- Reposted by Erwan GueguenResearchers uncover a new class of retropepsin-like proteases in P. aeruginosa that are required for biofilm formation & bacterial survival under stress conditions, including antibiotic exposure, making them appealing therapeutic targets. #mBio: asm.social/2sq
- Reposted by Erwan GueguenCheck out these amazing lipid-monolayer-trapping oligomeric OMPs published by @lalouxlab.bsky.social and Lovering Labs. The BAM complex in these bugs must be wild! www.nature.com/articles/s41...
- Reposted by Erwan GueguenWhere is the money going? In the case of for-profit publishers it's very clear: Your open access fees fund corporate profit margins. Profit margins for large academic publishers can far exceed those of household names like Amazon and Apple. chart source: bit.ly/4leULKi #scipub #academicsky
- It shouldn’t cost thousands of dollars to publish #OpenAccess. Where is that money even going??? #SciPub 🧪
- I am delighted to be taking part in the 8th meeting on RNA regulation in bacteria and archaea, to be held in Strasbourg from September 1-4. This is my first time, and I'm really looking forward to meeting the experts on this topic. microbialrnameeting.com #MicrobialRNAs
- Reposted by Erwan GueguenA paper in Nature presents an AI model that can outperform existing Earth system forecasts. The model, named Aurora, could enable more accurate and efficient forecasting of air quality, tropical cyclone paths, and ocean wave dynamics, as well as high-resolution weather forecasting. 🌊 ⚒️ 🧪
- Reposted by Erwan Gueguen🫴 Wow: A bacterial reverse transcriptase synthesizes long poly-A–rich cDNA for anti phage defense: 👇👇👇 @science.org www.science.org/doi/10.1126/...
- 🎓 Looking for a postdoc with a background in bacteriology to join my team to study pectinolytic bacteria via a #MSCA fellowship 🇪🇺 (up to 3 yrs in France). 📅 Expression of interest by June 15. The MSCA application deadline is September 10, 2025. 🔗 Info in attached files #Pectobacteriaceae
- Reposted by Erwan GueguenLe MMSB propose une mobilité NOEMI Rejoignez l'équipe "Ecologie et Évolution Moléculaire des Phages" qui travaille sur les éléments génétiques mobiles et l'immunité bactérienne. Profil Génétique bactérienne, Écologie microbienne et Evolution expérimentale 🤝Contactez-nous pour rejoindre notre unité!
- Reposted by Erwan GueguenThe US is literally losing its mind... killing valuable research programs, and more seriously, damaging what makes US science so strong: it's attractiveness for the best minds in the world.
- Reposted by Erwan GueguenSoftAlign: End-to-end protein structures alignment biorxiv.org/content/10.1101/202…
- Reposted by Erwan GueguenSimpleViz: A User-Friendly, Web-Based Tool for Publication-Ready Data Visualization in Bioinformatics www.sciencedirect.com/science/arti...
- With each passing day, the articles I read about the Trump administration's research policy plunge me into a deeper and deeper state of dismay. 1/3 www.forbes.com/sites/johndr...
- It’s not just budget cuts or institutional neglect. It’s a deliberate effort to reshape science around ideological goals. 2/3
- This isn’t new in history. The Soviet Union had Lysenko — a man whose pseudoscience thrived because it pleased power. The damage lasted generations. We should know better. 3/3
- Reposted by Erwan GueguenAt least 10% of the V. cholerae integron cassettes have novel antiphage activities (see below). Considering that there are 25,000 distinct cassettes of unknown function, integrons constitute an extraordinary and almost inexhaustible reservoir of antiphage functions!
- Our latest publication has just been released. As I am no longer working on this project, I can share the strains with any team wishing to continue it. It was fun but impossible to work on everything. #pseudomonas #putida enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
- Submission open for the 8th Meeting on Regulating with RNA in Bacteria and Archaea, September 1 – 4, 2025, Strasbourg. microbialrnameeting.com
- Reposted by Erwan GueguenPseudomonas syringae subpopulations cooperate by coordinating flagellar and type III secretion spatiotemporal dynamics to facilitate plant infection www.nature.com/articles/s41...
- Reposted by Erwan GueguenAprès 7️⃣ longues années d’absence, l’École Thématique de Microbiologie Moléculaire fait enfin son grand retour ! 🦠 On vous donne RDV : 📅 6-10 Octobre 2025 📍 Carry-Le-Rouet (13) 🇫🇷 🔗 lcb.cnrs.fr/etmm2025/
- "My usual advice to anyone thinking about a lab-based career in science is not to do it unless you can’t imagine not doing it. It is frequently all-consuming, you are never finished, and the outcomes are not always what we want. " 1/2
- "But it is never boring, on occasion extremely exciting, and seeing (and hopefully helping) the next generations of scientists develop in the laboratory is probably the best long-term aspect of a research career." Susan Gottesman
- Reposted by Erwan GueguenSociety journals vs. #NatureRipoffs @manavellalab @ASPB @NaturePlants
- Reposted by Erwan GueguenNew research in Science represents a notable step forward in designing enzymes from scratch. With a new approach, researchers designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, analogous to what many proteases do when breaking apart proteins. scim.ag/41kZBOI
- Reposted by Erwan GueguenExcited to share our latest preprint! A fascinating story of chemical dialogue and microbial warfare: the Bacillus extracellular matrix acts as a key driver in the antagonistic interaction with Botrytis, while the fungus mounts a multi-layered defense. 🔗 www.biorxiv.org/content/10.1...
- Reposted by Erwan GueguenProPr54 web server: predicting σ54 promoters and regulon with a hybrid convolutional and recurrent deep neural network #NAR from Anne de Jong 👉 propr54.molgenrug.nl academic.oup.com/nargab/artic...
- Reposted by Erwan GueguenI was just told that I have to remove “climate” from the title of an ongoing grant if I want to keep it. And publications from that grant cannot include “climate” and other forbidden words. I can’t believe I’m writing this from the United States of America. #AcademicSky
- Reposted by Erwan GueguenA type II secreted subtilase from commensal rhizobacteria cleaves immune elicitor peptides and suppresses flg22-induced immune activation
- Reposted by Erwan GueguenFoldseek-Multimer—now published in @naturemethods.bsky.social—our fast multimer search tool, enables complex comparisons against the full PDB in seconds. It comes with BFMD, a collection of 300K+ predictions gathered from community projects. 📄 nature.com/articles/s41... 🌐 search.foldseek.com
- 🫣 I understand better why the buildings of private American universities are very nice and why salaries are higher than those of French university professors.
- I'm not saying that reducing overhead rates is a good thing. I'm just pointing out the difference between the French and American systems (overhead rates are limited to 15% in France), which explains the lack of resources at french universities.
- Reposted by Erwan GueguenDesign and regulation of engineered bacteria for environmental release Review in @naturemicrobiol.bsky.social by Yonatan Chemlaet al from Christopher A. Voigt www.nature.com/articles/s41...
- Reposted by Erwan GueguenProtein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/...
- Reposted by Erwan GueguenNew preprint from our Lesterlin Lab! Yannick Baffert and @nfrk92.bsky.social, in collaboration with @macerwan.bsky.social and @val-meve.bsky.social, shed light on the molecular mechanisms driving pOXA-48 plasmid maintenance and transfer. We reveal novel TA system, regulators, and T4SS components!
- Reposted by Erwan GueguenL’Institut Pasteur décide de quitter X (ex-Twitter) pour rejoindre BlueSky ! 🦋 L’Institut Pasteur a pris cette décision en raison de plusieurs dérives graves constatées sur la plateforme X depuis son rachat. Rejoignez-nous pour continuer à défendre la science ! www.pasteur.fr/fr/espace-pr...
- Reposted by Erwan GueguenFresh out of the press! ✨Check out our new paper on the violent entry of the HIV capsid into the nuclear pore — and how it cracks the gate! 🤯 💥 Incredible work from @becklab.bsky.social and @hummerlab.bsky.social 🤩 More here: www.biophys.mpg.de/2842024/hivcapsid-cracks-the-npc?c=2011019 🔗 #teamTOMO
- Reposted by Erwan GueguenOur new review article "Microbial secondary metabolites: advancements to accelerate discovery towards application" in Nature Reviews Microbiology is now published! rdcu.be/d6BHX
- Reposted by Erwan GueguenIntroducing Nature Reviews Biodiversity! This Review explores the relationship between emerging infectious diseases and biodiversity loss, and how both are connected to global environmental changes in the Anthropocene. go.nature.com/42fzUQk 🧪
- Reposted by Erwan Gueguen#IDSky #MedSky required reading: Multidrug-resistant Gram-negative bacterial infections Nenad Macesic, Anne-Catrin Uhlemann, Anton Peleg Review in @thelancet.bsky.social doi.org/10.1016/S014...
- I just discovered there's a sorting cytometer 50m from my lab, fully accessible at an affordable usage cost. Oh, the joy of imagining all the possibilities it opens up for genetic screening! www.sciencedirect.com/science/arti...
- Reposted by Erwan GueguenNew Cell Host Microbe @philcarella.bsky.social Is any plant safe? Pseudomonas syringae caused disease in a liverwort, a fern, and a flowering plant last sharing a common ancestor >500 million years ago Key drivers of disease: Type-3 effectors + the necrotizing lipopeptide phytotoxin syringomycin
- Reposted by Erwan GueguenTrès honorée et émue de faire partie des 2 lauréats 2024 du prix Agnes Ullmann, pionnière de la recherche sur la régulation de l'expression des gènes des bactéries. Toute ma gratitude à l'Institut Pasteur, au comité de sélection, et toutes mes collaboratrices et collaborateurs x.com/institutpast...
- Reposted by Erwan GueguenToday we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
- Reposted by Erwan Gueguen📰 Tribune de 2829 chercheurs dans @lemonde.fr : www.lemonde.fr/sciences/art...
- Reposted by Erwan GueguenNew paper out! We show that heart cockles use bundled fiber optic cables to transmit light through "skylights" in their shell for their photosynthetic algae. The skylights filter out harmful UV radiation. These coral analogues are cool critters!! www.nature.com/articles/s41...
- Reposted by Erwan GueguenWe updated our BindCraft preprint with lots of new exciting results! We release all our binder sequences and models, include more in silico analysis, novel design targets, and present AAV retargeting to specific cell types using de novo binders! www.biorxiv.org/content/10.1...
