Max Fürst
Asst. Prof. Uni Groningen 🇳🇱
Comp & Exp Biochemist, Protein Engineer, 'Would-be designer' (F. Arnold) | SynBio | HT Screens & Selections | Nucleic Acid Enzymes | Biocatalysis | Rstats & Datavis
https://www.fuerstlab.com
orcid.org/0000-0001-7720-9
- I am excited to share that I will be starting my lab @Sanquin-forlife Research in Amsterdam this month! Looking forward to do structural biology and use protein engineering to tackle important questions related to 🩸blood🩸 protein complexes in health and disease. 🧬🧫🔬🧪👨🔬 #cryoEM #xtallography
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- Given the hollow cage-like structures of ROOL and GOLLD complexes, researchers suggest that they may act as structural scaffolds within the cell, helping to sequester or compartmentalize cellular components. More at Molecule of the Month: pdb101.rcsb.org/motm...
- The final version of our new paper is out now - and open access @acs.org Central Science!! Such a fun collaboration! pubs.acs.org/doi/10.1021/...
- Excited to share a new pre-print on a joint study between my group and @chembiobryan.bsky.social! Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling. chemrxiv.org/engage/chemr... 1/n
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- Just because you can doesn't mean you should.
- New Preprint!! We show that binding entropy can be quantitatively predicted from crystallographic ensemble models, accounting for both protein conformational entropy and solvent entropy! www.biorxiv.org/content/10.6...
- The barrel-shaped structures found by the thousands in most animal cells are one of biology’s biggest mysteries. But although researchers haven’t figured out the function of these “vaults,” they now report a new use for the puzzling particles. Learn more: scim.ag/49pv8mB
- New Brief Communication: "A CRISPR-based sequence proximity binding protein labelling system for scanning upstream regulatory proteins" rdcu.be/eZLUP CRISPR-based proximity labelling system to profile DNA-binding proteins such as PIF4 transcription factor .
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- X is cooked I hope people I like are still here instead. Please don't make me go to LinkedIn
- Mapping proteins, one side chain at a time Roland L. Dunbrack Jr. receives the ASBMB DeLano Award for Computational Biosciences
- Some more evidence that BioEmu et al have largely rendered clever AF2 template and MSA hacks obsolete for quick conformational sampling of soluble monomeric proteins
- Accelerated sampling of protein dynamics using BioEmu augmented molecular simulation [new] BioEmu aids mol. simulation: capturing biomolecular dynamics (kinase transitions, mutation effects) via broader conformations.
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View full threadI saw this, but this would only work if you were sure your reference distribution covered the full landscape right? It wouldn’t work for mutations that discover new states
- You can mess up a kinase structure in any which way with MD and claim you’ve “discovered” a new state. Doesn’t make it real or relevant or interesting. Has to correlate with experimental data.
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- Video introduction to our new “Conformational Biasing” method for computational design of mutations that bias proteins towards desired conformational states CB part starts at 14:55 Thanks to Peter Cavanagh and Andrew Xue – amazing graduate students who co-led this work
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- A systematic analysis of STAND NTPases and their associated sensor domains in bacterial immunity 🤯 Mind-blowing work !
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- Thank you for submitting to Nature Years. Based on feedback from independent expert reviewers, we are unable to accept 2026 in its present form. If you feel up to the task, we would be willing to consider a substantially revised version that addresses the major concerns raised...
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- First Pipeline post of the year! A statement of purpose, and science topics resume on Monday:
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- Want to discover great posts beyond who you already follow? The For You feed, built by @spacecowboy17.bsky.social, is a personalized algorithmic feed based on your likes. It's one of our favorites for finding cool conversations across the network. Try it here: bsky.app/profile/spac...
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- Signalling by ubiquitination is... ubiquitous ! It regulates virtually all cellular processes in eukaryotes. Bacteria do not encode a functional ubiquitin system, yet some can manipulate ubiquitin signalling in their host. This example 𝐛𝐫𝐞𝐚𝐤𝐬 𝐚𝐥𝐥 𝐫𝐮𝐥𝐞𝐬 ! 1/3
- Today I made a small but momentous start to work in 2026 by changing a single number. I renamed the file “Papers to write and submit in 2025” to “Papers to write and submit in 2026”. Stay tuned for more file updates on 1st January 2027.
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- Manchester Institute of Biotechnology is looking for a new Professor. There are a few priority areas including microbial engineering (broadly defined, from pathways to cells to microbiomes). Closing 12 Jan. Join us in the best city in the UK 😜 www.jobs.manchester.ac.uk/Job/JobDetai...
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- Fantastic! $650k awarded via the Research Software Maintenance Fund for “Enabling the Next Generation of Contributors to R”—mentoring new contributors, modernizing R’s dev infrastructure, and strengthening the R Foundation. r-consortium.org/posts/650K-f... #rstats
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- I asked participants for tips attending scientific conferences #BES2025 youtu.be/ow_ickvkvbA?...
- Funny animal videos no longer being trustworthy just fucking sucks all around. I love the wonder of animal behavior and what it says about the experience of being alive. It's because it happened in reality that it's so fun. It's not fun if it was just made up. There's no wonder there.
- Ok, this is nuts. Once you see it you cannot unsee it. Do you see it? (OP @drgbuckingham.bsky.social )
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- New preprint🚨 Imagine (re)designing a protein via inverse folding. AF2 predicts the designed sequence to a structure with pLDDT 94 & you get 1.8 Å RMSD to the input. Perfect design? What if I told u that the structure has 4 solvent-exposed Trp and 3 Pro where a Gly should be? Why to be wary🧵👇
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View full threadThanks to Seva and Kerlen for their tireless effort to get the data as watertight as possible. Here is the preprint link again: www.biorxiv.org/content/10.6... 19/19
- I really enjoyed this paper, thank you! Did you consider AF2 initial guess or AF2 rank for AF2-ss with the native or MSA-predicted structure as input? I wonder if the improved native structure performance would be worth the likely increase in false positives
- Our new paper on DusB’s role in redox metabolism in V. cholerae is now out in @narjournal.bsky.social linking tRNAmodif enzymes and metabolic adaptation. Beyond RNA modification: a tRNA-modifying enzyme shaping oxidative stress resilience and metabolism in V. cholerae #rnasky #rnabiology 😊🦠💫
- The #BEASTLab won second place in the departmental holiday decoration contest!
- What’s your end of the year task? Cleaning all the reason we use in half a year. Of course on an indestructible Amersham era pump with its detector intact
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- I'm super excited to announce the first preprint of my PhD, together with Chenxi Ou and @sokrypton.org! ML has revolutionized protein modeling, but crucial challenges remain. For example, we can't reliably predict complicated protein structures without MSAs, which limits what we can design.
