Kelvin Lau @klausenhauser on 🙅♂️🐘🪡
🇨🇦🇭🇰 @EPFL_en protein production + structure facility 🇨🇭| ex @ubc @uwaterloo @unige_en | here for #proteins #structuralbiology #xray #cryoem #plants #mountains #politics #transit #urbanism 🐱🐈 staying for the #hottakes | My views here🧪🧬🌱🔬🏳️🌈
- First vacation that I spent more on museums and temples than on food. What a rich cultural history Egypt has spanning millennia
- Those were some Pharonic and Islamic places of interests. Lots of Beautiful Coptic ones as well and some rare Synagogues
- Its that time of the year again OOO
- My favourite place this weekend. And some new infrastructure sightings. New train and a new gondola mid level station (nicer than some airports!)
- What’s your end of the year task? Cleaning all the reason we use in half a year. Of course on an indestructible Amersham era pump with its detector intact
- Oops *resin!
- Seen elsewhere… and was triggered. Don’t think I would set up the void peak that has the lower melting temperature if I only had one chance. The small monomer and higher melting curve in the dotted example however.. don’t trust your AI infographics
- Saw this nice short protocol paper on LI. Not totally HTP but totally feasible in an academic lab. Right in the intersection of drug discovery, automation, structural biology and protein expression. Ps the guys looking for a job downunder! www.biorxiv.org/content/10.6...
- Most protein design binders look the same, bundles of alpha helices or clearly a VHH. But the strategies in getting there are getting more diverse. The pipelines that humans are deciding to use are super interesting. proteinbase.com/competitions...
- Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡Lots of fun working on this project! Looking forward to see more and more animations published in the future!
- Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published: journals.biologists.com/jcs/article/... The result of a fantastic Iwasa-Drubin lab collaboration. @margotriggi.bsky.social @jiwasa.bsky.social movie.biologists.com/video/10.124...
- Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡Let’s wrap things up: my commentary on the Asgard hypernucleosomes. Congratulations to all the authors of the paper 🍾! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... Cryo-EM reveals open and closed Asgard chromatin assemblies: Molecular Cell www.cell.com/molecular-ce...
- looking back at things to delete. I loved this protein. It makes for fun questions to ask for undergrads.
- Interesting SEC as well. Hint: putative lectin binder.
- #1 lesson I give to protein designers for wet lab purposes : Please design with a Trp and/or multiple Tyr. Please do not design with 10 cysteines.
- Good end to a week with a good batch of 🧬✂️
- It looked better in 4K
- Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡For-profit journals are supposed to improve research quality, yet they're perversely incentivized to churn out whatever they can monetize. This was happening before AI (see Strain: bit.ly/43gJPUM), and AI will make it worse. It's insane that we volunteer our time to help them do so. 4/n
- Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡[This post could not be retrieved]
- Want @cytiva.bsky.social please make a Gradient Supedex www.sciencedirect.com/science/arti...
- Saw this over on LI. Very slick and rasy to use mask generator. No more tinkering around needed like before. mcalbyrne.com/cryomaskr.html Video: www.linkedin.com/posts/mcalby...
- Cleaning an office and this is my absolute nightmare circa 2008. Thank goodness most people have moved beyond word files and sequences… but not all 😌
- developer.nvidia.com/blog/introdu... Will this finally be a codon optimizer that works? Still haven’t ever used a magic bullet but I do know not only the codons but the whole sequence play a big role
- Ever since this observation, still haven’t found a pattern
- Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡I am delighted to share this work, led by Miguel Alcantar and done in collaboration with Amgen, on the OrthoRep-driven evolution of computationally designed minibinders. Here, we focus not only on getting high affinity, but also on mapping sequence-affinity landscapes of diverse outcomes.
- Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡We train machine learning models on millions of proteins. But when it comes to making predictions, do we need them to understand all proteins at once? Often, we need an accurate model for the specific protein we are studying or designing. We address this with ProteinTTT arxiv.org/abs/2411.02109 1/🧵
- Just did my multiple choice get to know the country 🇨🇭 naturalization test. Now time for some sauna.. wait that’s the wrong country 🇫🇮 .
- Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡I am fascinated by how viruses evolve - and not just since #SARSCoV2 has shown us at the global stage how consequential virus evolution can be for us. In my new story in @science.org I got to explore how researchers are probing deeper into the past with old RNA virus genome. So a 🧪 thread…
- Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡Thrilled to announce our new preprint, “Protein Hunter: Exploiting Structure Hallucination within Diffusion for Protein Design,” in collaboration with @Griffin, @GBhardwaj8 and @sokrypton.org 🧬Code and notebooks will be released by the end of this week. 🎧Golden- Kpop Demon Hunters
- Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡🚨Our paper is out! 🥳 Hijacking a bacterial ABC transporter for efficient genetic code expansion. Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social www.nature.com/articles/s41... it all started years ago with a failed experiment 🧵👇 1/9
- Any structural biologists who want some fun? Try building mirror folds. When you’re building them you seriously innately feel like this is “off” but they do exist! When I looked at some of these datasets and deciding which way to turn in Coot it was so offsetting www.biorxiv.org/content/10.1...
- After the conference comes the weekend :) Strasbourg and Basel + region what a nice combo. Strasbourg Munster or Roche towers? ⛪️🏢
- Finished an exciting 38th Rhine Knee Structural 🧫💎🔬biology meeting lnkd.in/eYse4giF ! See you back in Switzerland in 2026!
- Organized by excellent researchers from Strasbourg (IGBMC) and held inside a Monastery. Many groups from the region bordering the Rhine, France 🇫🇷 , Switzerland 🇨🇭 and Germany 🇩🇪 listened and discussed how structural biology has moved since the 1990.
- We discovered new projects and complementary techniques (watch out NMR and MS is coming back!), hot structural biology topics (new processing algorithms, grids!) and what AI has done (automated structure determination by NMR) or has failed (so far; ligands and RNA) to achieve in Structural Biology
- Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡How do SMC complexes load onto DNA to get ready for loop extrusion? @roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️. Check out the new paper: www.cell.com/molecular-ce...
- Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡The latest #AlphaFold DB update is out! We synchronised with UniProt release 2025_03, predicted protein isoforms across all species, and provide MSAs used to generate each prediction. Proud of the team at the PDBe for the hard work that went into this. Grateful to play my part in it!
- We’re renewing our collaboration with Google DeepMind! We'll keep developing the AlphaFold Database to support protein science worldwide 🎉 To mark the moment we’ve synchronised the database with UniProtKB release 2025_03. www.ebi.ac.uk/about/news/t... 🖥️🧬 #AlphaFold @pdbeurope.bsky.social
- Hmmm a library of protein designs all assessed for binding on the same platform. All with sequences, both positive and negative data. Makes for much better comparison than those made via paper claims. proteinbase.com
- Have heard this being suggested by many, but haven’t seen anything real until now
- Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡NEW: In 2025, 43% of young American adults regularly get their news from TikTok. www.pewresearch.org/short-reads/...
- Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.
- Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪
- Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡Be our neighbour !
- Be our new colleague! 🎉 The Dept of Molecular and Cellular Biology at the University of Geneva is hiring an Assistant Professor or Associate Professor. 👉 More details here: lnkd.in/e8Z9eAm4 👉 Our department: mocel.unige.ch Please feel free to share this opportunity with your network.
