Bryan Dickinson
chemical/synthetic biologist, Luddite trying to find better ways to make molecules that do important stuff, dad, @uchicago professor of chemistry
dickinsonlab.uchicago.edu
- The final version of our new paper is out now - and open access @acs.org Central Science!! Such a fun collaboration! pubs.acs.org/doi/10.1021/...
- Excited to share a new pre-print on a joint study between my group and @chembiobryan.bsky.social! Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling. chemrxiv.org/engage/chemr... 1/n
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- 1/ Check out our newest paper where we ask: How fast can we experimentally discover binders from scratch? And we mean scratch: a blinded study. TLDR: 26 days. And the binders work…and led to new cancer biology. We’re coming for you AI…. chemrxiv.org/engage/chemr...
- 2/ The problem: Protein binders are essential tools for research and therapeutics, but discovering them is slow, expensive, and unpredictable. We wanted to know—can our recently developed PANCS-Binders tech deliver on real-world timelines for targets that matter? www.nature.com/articles/s41...
- Reposted by Bryan DickinsonOrganelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
- Organelles harbour pH gradients biorxiv.org/content/10.64898/20…
- Reposted by Bryan DickinsonOne more paper from our lab! This ACS Synthetic Biology paper reports bottom-up construction of eukaryotic-like synthetic cells with an artificial nucleus-like organelle, enabling on-demand protein localization control by a small molecule. 💊 pubs.acs.org/doi/full/10....
- Reposted by Bryan DickinsonOur latest paper on a novel synthetic condensate platform, LAMA-SPREC, is out in ACS Chemical Biology! It enables chemically switchable and reversible control of protein function via sequestration and release in mammalian cells. 🔬💊🚿 pubs.acs.org/doi/full/10....
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- Check out our newest work! This is a story on how to get selectivity in binders - both isoform and site selectivity. Read the paper or enjoy this brief Skytorial of what we did! www.biorxiv.org/content/10.1... 1/n
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- Okay okay. How about THE EUROPEAN chemical biology conference. Seems like good people attending Janelia too. Except that Bryan guy?? What the heck has he done recently?
- Registration for THE chemical biology conference of 2026 is now open! EMBO ChemBio 2026 in Heidelberg DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social www.embl.org/about/info/c...
- I ran out of space and there are too many stars to list... Mi Hee Lim, Allie Obermeyer, Chu Wang.... read the website and tag people here if they are on bluesky. I can't wait to attend. If you have never been, Heidelberg in September is lovely. Come hang out and send your students and postdocs!
- Do you study lipids or lipidation, but don't know where to send your newest work? Send us your fat papers, phat papers, and even phatty acid papers. While the special issue is not saturated, it's filling up fast, and won't be unsaturated forever! Phase separate with us and build community!
- #ACSChemBio and #Biochemistry invite submissions to a special issue on Lipids and Lipidation guest edited by @chembiobryan.bsky.social and me! Find details in the #CallforPapers and submit your exciting findings to one of these journals by May 31, 2026. axial.acs.org/chemical-bio... #lipidtime
- Reposted by Bryan Dickinson🚨Our paper is out! 🥳 Hijacking a bacterial ABC transporter for efficient genetic code expansion. Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social www.nature.com/articles/s41... it all started years ago with a failed experiment 🧵👇 1/9
- Congrats to my fantastic colleague!!! Go Anna!!
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