Mark Levin
Professor of Chemistry
University of Chicago
Single-Atom Skeletal Editing
(Interspersed with doomposting and AI skepticism)
Husband, Dad, Crossword Addict
http://levingroup.uchicago.edu
- Pro-LLM academics bemoaning how long it takes to write and review papers are telling on themselves. Those tasks are supposed to take a long time because that's how you can be thoughtful, thorough, and rigorous. Filtering yourself is how you only communicate things you think are worth reading.
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- Reposted by Mark LevinBREAKING Greg Bovino has been removed as Border Patrol "commander at large" and will return to El Centro Calif, where he is expected to retire soon. A stunning turnaround after Pretti killing. Bovino's traveling blue city crackdown is over www.theatlantic.com/politics/202...
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- Today on @chemrxiv.org, we disclose a C-to-N replacement that actually works complex natural products - a pipe-dream when we started. The secret is to lean in to the triplet nitrene. Congrats Dong Il, and thanks to the whole team, including collaborators from Sanofi! chemrxiv.org/engage/chemr...
- Reposted by Mark Levinif you want a long read that involves udders, a hot air balloon, and some extremely dubious data on egg prices, the story I’ve been working on for the last few months where I tried to single-handedly take on every government function myself is now online! www.theatlantic.com/magazine/202...
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- Reposted by Mark LevinThe National Weather Service used AI to create a forecast for Idaho. Low chances of wind for the nonexistent towns of Cocrerrireod, Orangeotild and Whata Bod www.washingtonpost.com/weather/2026...
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- Reposted by Mark LevinOk here it is - out of 44 FDA approvals this year, 31 are small molecules (70%), 26 of those are oral drugs (84%), 22 of them are chiral (71%). This is the largest number and percentage of chiral FDA approved molecules in a single year. Fitusiran is not a small molecule, bonus.
- Just in time for the new year - we show that you can make either isomer of N-aryl pyrazole selectively from a single TDSO. We really believe in the power of these wacky heterocycles. chemrxiv.org/engage/chemr... Excellent work by superstar Alex Fanourakis, in collab with Osvaldo Gutierrez and J&J
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- Reposted by Mark Levinsuspect a big reason why many academics and others who work in areas where getting facts RIGHT is key are disinterested in using LLMs for research: they’ve tried it, they keep noticing major errors in output, and they conclude that having to verify all that doesn’t actually save them time.
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- Every morning while making coffee www.poetryfoundation.org/poetrymagazi...
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- God I wish it was only because of DOGE
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- Reposted by Mark LevinEvery ad now
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- Reposted by Mark LevinPSA for people with NIH grant periods starting January 1st (including most NIGMS MIRAs): your RPPR is due Saturday, but they haven’t sent out the usual automated reminders, presumably due to the shutdown
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- A true pleasure to host Koji Kubota @uchichemistry.bsky.social for a stop on his Merck Banyu Lectureship Award Tour!
- New @chemrxiv.org, a collaboration with @honggen-wang.bsky.social and group alum, now asst prof. Myojeong Kim: the first true catalytic interception of isodiazene-generated primary-amine-derived radicals. The key is an N-F reagent that enables productive chain carrying! doi.org/10.26434/che...
- Reposted by Mark LevinPlease join us in congratulating Neubauer Family Assistant Prof Anna Wuttig, who has been named the recipient of the 2025 Early Excellence in Science Award in Chemistry. The Bayer Foundation is honoring her "for advancing electrocatalysis for energy storage, conversion, and medicinal chemistry."
- Be my colleague! apply.interfolio.com/175745
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- Reposted by Mark LevinSix of the nine Nobel Prize winners this year work in the U.S. Three of the six were born outside the U.S., which is the pattern most years. No country has benefited more from welcoming immigrants from around the world. www.nobelprize.org
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