Stephanie Wankowicz
Computational Structural Biologist
Assistant Professor @VanderbiltMPB
wankowiczlab.com
(she/her)
Past: UCSF, Dana-Farber, Broad Institute, UMass Amherst
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- Reposted by Stephanie WankowiczNot new, but a new to us update: The first preprint out of my lab! We joined forces with @kinasekid.bsky.social @jasonzxzhang.bsky.social and David Baker to study protein phosphorylation! Congrats to Isabella from my lab on her first first author paper! tinyurl.com/43jwwfua
- New TTPD with @fraserlab.com! We chat about travels, new preprints, and vibe coding. podcasts.apple.com/us/podcast/b... open.spotify.com/episode/6QCR...
- Reposted by Stephanie WankowiczI post politically on eXtwitter and no science/tech, and here only post on science/tech. But we must not look away from what is happening right now, out in the open with no regard for morality or human life. Do not look away.
- New Preprint!! We show that binding entropy can be quantitatively predicted from crystallographic ensemble models, accounting for both protein conformational entropy and solvent entropy! www.biorxiv.org/content/10.6...
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- Now is the time to make real the promises of democracy. Now is the time to rise from the dark and desolate valley of segregation to the sunlit path of racial justice...Let us not seek to satisfy our thirst for freedom by drinking from the cup of bitterness and hatred. -MLK Jr.
- Reposted by Stephanie WankowiczNew job alert! If you're passionate about open science, organized, enthusiastic about meeting new people doing exciting work in this space, and want to nerd out with me on all the ways we can move the needle on open science @asterainstitute.bsky.social, apply now! jobs.ashbyhq.com/astera/f085e...
- I can't recommend this enough both for the people you get to work with and the topic of the work!!
- Internship opportunity! @jackn.bsky.social and I have opened two Summer Intern positions at Genentech to build structural biology agents. If you are a (pre-PhD) #cryoEM or #Xray structural biologist with strong computational skills & motivation, please apply!
- Reposted by Stephanie WankowiczTen rules for a structural bioinformatic analysis PLOS Comp Bio offers a roadmap for users to leverage the Protein Data Bank’s vast collection of protein structural models into reliable and valuable insights.
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- Reposted by Stephanie WankowiczSo 2025 turned out to be a big year for de novo antibody design! Here are thoughts and predictions on the state of de novo antibody design heading into 2026 🧵
- Last TTPD of the year! We talk about trends over 2025 and predictions for 2026 and beyond! @fraserlab.com podcasts.apple.com/us/podcast/s...
- Reposted by Stephanie WankowiczOur latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study! www.nature.com/articles/s41...
- Reposted by Stephanie WankowiczHappy Nobel Prize Day to those that celebrate! Thanks for highlighting our work its connection to Stanley Cohen!
- ⭐ Happy Nobel Prize Day! Vanderbilt Nobel Laureate Stanley Cohen transformed biology with his discovery of EGF. Today, that legacy lives on through researchers like @krishnamudumbi.bsky.social, who is pushing the study of signal transduction into new territory. 🎥 Watch the video!
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- New preprint! Entropy drives molecular recognition, yet most structure-based drug design ignores it because it is difficult to measure. X-ray crystallography captures ensembles, not single structures. Can we extract thermodynamically meaningful entropy from them? www.biorxiv.org/content/10.1...
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- TTPD Episode 9 with @fraserlab.com: I Can Do It With a Broken Grant Cycle (Sorry for the crappy audio in places!) Topics: Government Shutdown/Reopening, Travels, Jane Richardson's impact (en.wikipedia.org/wiki/Jane_S....), Arena BioWorks closing, AI review tools wankowiczlab.com/2025/11/24/T...
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- Reposted by Stephanie WankowiczAnnouncing cryo-EM heterogeneity challenge #2, now dubbed the 2025 Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction Algorithms (CAHRA)! Join us for a webinar next Friday (Nov 14th) to learn more. Datasets already posted here: heterogeneity.notion.site/challenge #cryoem
- ❤️
- The Leading Edge Fellows gathered this week to celebrate Zara Weinberg, a beloved member of our community. Our 7th cohort of Leading Edge Fellows (2026) will be named in her honor. The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2. www.leadingedgesymposium.org/apply/
- Reposted by Stephanie WankowiczZara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed. She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
- Can confirm. www.wsj.com/lifestyle/si...
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- Reposted by Stephanie Wankowicz1. We ( @jbakcoleman.bsky.social, @cailinmeister.bsky.social, @jevinwest.bsky.social, and I) have a new preprint up on the arXiv. There we explore how social media companies and other online information technology firms are able to manipulate scientific research about the effects of their products.
- Reposted by Stephanie Wankowicz**Job Alert** Exciting postdoc position available: theoretical and experimental cryo-EM studies of flexible biomolecules. Competitive salary, collaborative environment at NYSBC and Flatiron Institute. Please share!! and contact: pcossio@flatironinstitute.org
- TTPD #8 with @fraserlab.com: Open access, Clear science, Full hearts, Can’t lose! We chat about the Compact for Academic Excellence in Higher Education, HHMI open access, the government shutdown, the BEAR, the Nobel Prizes, and The Life of a Showgirl! wankowiczlab.com/2025/10/23/T...
- Updated preprint on the roadmap to predicting macromolecular ensembles with @bonomimax.bsky.social! Four key issues: 1) Structural ensembles are defined inconsistently across disciplines. 2) No single experimental technique alone can fully capture structural ensembles arxiv.org/abs/2505.01919
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