Alexis Rohou
CryoEM and structural biology methods, drug discovery. Also: Celtics, Camus, rocksteady, drum and bass. He, him, his.
- As much as the NYT’s editors drive me up the wall at times with overly cautious headlines, other parts of the coverage is really excellent IMO. This autocracy index tracker is crisp and unflinching. Surely not perfect but a great overview of where we stand on the autocratic spectrum.
- Reposted by Alexis Rohou“Your mountainish inhumanity” We’re doing this to ourselves
- Reposted by Alexis RohouFor those in California, please consider signing the petition to support a $23 billion initiative for the California Foundation for Science and Health Research www.fundcascience.org
- Reposted by Alexis Rohou
- Reposted by Alexis RohouAgain, this is FALSE. Administrative warrants are NOT signed by an immigration judge (or any judge at all). They are generated and signed by ICE officers themselves with no external oversight whatsoever. Here is a blank sample warrant. Note who signs off on it; an "immigration officer."
- Beautiful writing!
- So many lucid points below. Incl on how to think abt free speech issues brought up by backlash on campuses when illiberal right-wingers are invited to speak. Also, and this has agitated me since Jan 2025: those who railed against cancel culture seem at ease with state-enforced speech restrictions.
- Reposted by Alexis RohouI was a White House staffer. When having a lunch with anyone who worked at law firm, corp, embassy, *newspaper* I had to document that I'd paid exactly my share of the bill. ("No free lunch" policy.) At some formal event dinners, had to calculate fair-market cost of my serving, and reimburse it
- Reposted by Alexis RohouSome jawdropping CBP crime statistics here...
- I testified Friday before Gov. Pritzker's commission studying abuses of ICE and CBP and tried to explain how the agencies went so far off track. It's actually way worse than I ever realized. Please read and share my testimony as Congress considers reform: www.doomsdayscenario.co/p/accountabi...
- .
- Reposted by Alexis RohouDuring WWII, the U.S. government forcibly took over 100,000 people of Japanese ancestry from their homes and held them in internment camps. Fred Korematsu was arrested and convicted for defying the government’s order and refusing to go to the camps.
- Reposted by Alexis RohouA rule I follow when reviewing cryo-EM manuscripts: if a claim relies on the orientation or interactions of a side chain, the evidence supporting the claim (ie the map density) must be shown. In general, reviewers are responsible for ensuring claims in manuscripts are supported by data.
- Reposted by Alexis Rohou
- Reposted by Alexis Rohou[Not loaded yet]
- Reposted by Alexis RohouI wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good. Stay free
- Reposted by Alexis RohouLots of guys with backwards ball caps and truck nutz never gonna listen to Philip Glass again
- Reposted by Alexis RohouCheck out our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3) 🔗 biorxiv.org/content/10.6...
- RIP Sly Dunbar. He now joins Robbie Shakespeare again. Hard to choose from hundreds of recordings but the session with Gainsbourg was recorded and mixed so well… it is a beautiful exemplar of perhaps the most famous rhythm section of reggae. Here is a later version featuring Big Youth.
- I’m no historian, nor political scientist, and the term is definitely overused, but…
- "Today, lawless and masked thugs masquerading as law enforcement officers brutally killed another American citizen on the streets of Minneapolis without justification”
- Reposted by Alexis Rohou[Not loaded yet]
- Reposted by Alexis Rohou[Not loaded yet]
- It seems that a crux of this matter is that there is no statute that specifies that victims of 4th amendment violations by fed agents can sue for damages. Recent Supreme Court rulings apparently makes this necessary- otherwise there’s no remedy available, even if the DHS policy is unconstitutional
- "Can ICE Enter a Home To Make an Arrest With Only an Administrative Warrant?" a deep dive for the law nerds new from me, posted over at Volokh. reason.com/volokh/2026/...
- The rule of law; separation of powers; the constitution and its amendments. According to the citizenship test I took just weeks ago, those are foundational principles of life in the USA. Available evidence shows that the current administration deliberately ignores and/or sabotages them. For shame!
- Reposted by Alexis RohouShe was absolutely right. And she would have been an amazing President.
- Reposted by Alexis Rohou[Not loaded yet]
- Reposted by Alexis RohouDOJ investigating whether Denmark lied on its Greenland mortgage.
- “Epidemic trespassing”. Seems like a useful phrase! First time reading it.
- Reposted by Alexis Rohou[Not loaded yet]
- Stop scrolling and post two characters who bring you happiness
- I've reviewed about 150 CVs in the past few days. A few observations: (1) I am sooo impressed by the talent pool out there; (2) do not try to make your CV fit onto one page if it makes things difficult to read - just go multipage, keeping the key messages upfront;
- (3) in the first 3-4 sec of seeing your CV I want to know: Your primary expertise - e.g. structural biologist? stem cell scientist? Your degree of expertise - grad student? postdoc? Any secondary expertise: e.g. a biologist who also codes, or a CS who also speaks science. Format accordingly please.
- Reposted by Alexis RohouGERMAN PRESIDENT STEINMEIER: “.. the United States has broken with the values that it helped to establish .. “.. we have now moved beyond the stage where we can lament the lack of respect for international law or the erosion of the international order; we are far beyond that, I believe.”
- Corvid aficionados 🐦⬛, one the crows at work (SF Bay Area) was making a very unusual call today. I’ve never heard a crow make that kind of sound. Not captured in video but it made usual caws after flying off so I’m pretty sure it’s a crow… anyone heard that kind of call before? @carlbergstrom.com?
- Internship opportunity! @jackn.bsky.social and I have opened two Summer Intern positions at Genentech to build structural biology agents. If you are a (pre-PhD) #cryoEM or #Xray structural biologist with strong computational skills & motivation, please apply!
- I have been having a lot of fun building MCP tools to help me work faster. For example, I now interact with our internal systems (such as our structure repository) mostly via an agent, and I have made some progress on having agents perform visualization tasks using ChimeraX.
- Reposted by Alexis RohouY’all might not appreciate it, but it took him 87 moves and 14 hours to get here
- Reposted by Alexis RohouOrganelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
- Organelles harbour pH gradients biorxiv.org/content/10.64898/20…
- RIP HopetonJames, what a sweet voice. youtu.be/bU2vFSRmz8E?...
- Reposted by Alexis Rohou[Not loaded yet]
- Reposted by Alexis Rohou[Not loaded yet]
- Reposted by Alexis Rohou[Not loaded yet]
- Lest we forget
- Reposted by Alexis RohouExcited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...
- Reposted by Alexis RohouDon’t forget:
- Reposted by Alexis Rohou[Not loaded yet]
- Reposted by Alexis RohouWe are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated. mrc.tal.net/vx/appcentre...
- Wonderful talk by the legendary Jane Richardson today on validation of #cryoEM and #xray protein structures as part of the S2C2 modeling and validation workshop at SLAC. I continue to be amazed by how deeply she understands macromolecular geometry.
- Reposted by Alexis Rohou[Not loaded yet]
- I’ll be there and the cryoEM/cryoET session lineup looks great. See you there?
- Reposted by Alexis RohouOpenFold3-preview (OF3p) is out: a sneak peek of our AF3-based structure prediction model. Our aim for OF3 is full AF3-parity for every modality. We now believe we have a clear path towards this goal and are releasing OF3p to enable building in the OF3 ecosystem. More👇
- Reposted by Alexis RohouHow do mRNA vaccines help fight cancer? A @nature.com paper today tells the story, one with big implications, as reviewed here erictopol.substack.com/p/how-mrna-v...
- Reposted by Alexis Rohou[Not loaded yet]
- Just closed applications for the next Bay Area #cryoEM meeting and wow… 270 applicants! Even more than the last one, 6 months ago.
- Very cool! Congratulations @vcushing.bsky.social @bjgreber.bsky.social and the whole team!
- New paper out now in Science! Check it out! www.science.org/doi/10.1126/...
- Reposted by Alexis RohouCheck out our preprint! With new molecular mechanisms, 140 subtomogram averages, and ~600 annotated cells under different conditions, we @embl.org were able to describe bacterial populations with in-cell #cryoET. And there’s a surprise at the end 🕵️ www.biorxiv.org/content/10.1... #teamtomo
- Trigger warning.
- Reposted by Alexis RohouRe-upping: Excellent assessment of John "Roger Taney" Roberts. In @harvardmagazine.bsky.social , by Lincoln Caplan. As careful, legally informed, judicious-minded writer as you're going to find. With an unsparing judgment. www.harvardmagazine.com/legal/suprem...
