Max Fürst
Asst. Prof. Uni Groningen 🇳🇱
Comp & Exp Biochemist, Protein Engineer, 'Would-be designer' (F. Arnold) | SynBio | HT Screens & Selections | Nucleic Acid Enzymes | Biocatalysis | Rstats & Datavis
https://www.fuerstlab.com
orcid.org/0000-0001-7720-9
- Reposted by Max FürstFirst-time posters need to be endorsed by an established arXiv author in their own field. The new rule is mostly to try and discourage people from trying to get something started by sending some rubbish to arXiv. 🦠🧪 www.science.org/content/arti...
- seeing that even claude code consistently doesn't get git commands right the first time round makes me feel much less stupid
- Reposted by Max FürstMy time in @martinsteinegger.bsky.social's group is ending, but I’m staying in Korea to build a lab at Sungkyunkwan University School of Medicine. If you or someone you know is interested in molecular machine learning and open-source bioinformatics, please reach out. I am hiring! mirdita.org
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- Reposted by Max FürstNew preprint! Led by @sarahgersing.bsky.social we map how 7,500+ variants in glucokinase (GCK) affect binding to GKRP and disentangle this from stability. We now have activity, abundance, and interaction scores for 7,128 GCK variants - a resource for understanding phenotypes and glucose homeostasis.
- Reposted by Max FürstWant to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version? I made an app you might like: adamkucharski.github.io/pdf2plot/ It all started a few years ago... 🧵
- The only format worse than pdb is cif
- Industrial computational protein engineering position in the south of the Netherlands synsilico.com/storage/app/...
- Reposted by Max FürstCan we design mutations that bias proteins towards desired conformational states? Today in @science.org, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.
- Reposted by Max FürstToday I made a small but momentous start to work in 2026 by changing a single number. I renamed the file “Papers to write and submit in 2025” to “Papers to write and submit in 2026”. Stay tuned for more file updates on 1st January 2027.
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- Caught between excitement that "one of us" appears on a major podcast and cringe for parts of the discussion (mainly the self promotion, sadly a hallmark of otherwise enjoyable #hardfork)
- Reposted by Max FürstI'm really excited to break up the holiday relaxation time with a new preprint that benchmarks AlphaFold3 (AF3)/“co-folding” methods with 2 new stringent performance tests. Thread below - but first some links: A longer take: fraserlab.com/2025/12/29/k... Preprint: www.biorxiv.org/content/10.6...
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- Reposted by Max Fürst"How can funders avoid crossing the Szilard point?" The Szilard point is "the threshold at which the total cost of competing for a grant equals (or surpasses) the value of the available funding."
- New preprint🚨 Imagine (re)designing a protein via inverse folding. AF2 predicts the designed sequence to a structure with pLDDT 94 & you get 1.8 Å RMSD to the input. Perfect design? What if I told u that the structure has 4 solvent-exposed Trp and 3 Pro where a Gly should be? Why to be wary🧵👇
- Wtaf
- Fun! Tldr AI researchers are pissed bc some AI research papers submitted to an AI conference by AI researcher colleagues is AI-written & many are AI-reviewed as found by an AI company's AI model, described in a paper for said AI conference. Said paper was also AI-reviewed (but deffo not AI-written)
- Reposted by Max Fürst
[Not loaded yet] - We've reached the bizarre state of things where poorly written emails in broken English are the ones that are the most relevant
