Sandra Hake
Professor for Genetics interested in chromatin structure, histone variants and histone modifications and their roles in gene regulation and disease development.
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- Extremely proud of my PhD student Lena Paasche, who won the prize for the best short-talk at the @gfgenetik.bsky.social symposium on "Epigenetics & Chromatin"! She is amazing: as scientist and as a wonderful and empathic person!
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- Reposted by Sandra HakePioneers of Epigenetics honored: Davor Solter & Azim Surani receive the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize. Their discovery of genomic imprinting revealed why mammals need both parents—opening the field of epigenetics. #Epigenetics #GenomicImprinting #PaulEhrlichPrize #CanSky #Science
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- Reposted by Sandra HakeJust half a day in and it’s been a blast, with really incredible talks here on Giessen!
- What a great first day at the GfG symposium on epigenetics & chromatin. Fantastic talks by @akispapantonis.bsky.social , @apombo1.bsky.social, @marcusbuschbeck.bsky.social and Philipp Korber. And Peter Becker giving the Max-Delbrueck lecture. A real treat for the audience!
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- Reposted by Sandra HakeWhat a great first day at the GfG symposium on epigenetics & chromatin. Fantastic talks by @akispapantonis.bsky.social , @apombo1.bsky.social, @marcusbuschbeck.bsky.social and Philipp Korber. And Peter Becker giving the Max-Delbrueck lecture. A real treat for the audience!
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- Reposted by Sandra HakePlease re-post: Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo... Abstract deadline: 30 September
- Reposted by Sandra Hake#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
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- Reposted by Sandra Hakeout today: my labmate Shubham developed a super clever new technique to profile TF-DNA interactions with unprecedented resolution of low-affinity binding sites, revealing patterns in how these sites are organized in the genome to modulate TF occupancy: www.nature.com/articles/s41...
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- Reposted by Sandra HakePlease share! PhD projects available through @gw4biomeddtp.bsky.social Please get in touch if you are interested in studying chromatin biology in stem cell models gw4biomed.ac.uk/architects-o... gw4biomed.ac.uk/risk-vs-prot... gw4biomed.ac.uk/rna-dependen... gw4biomed.ac.uk/investigatin...
- Reposted by Sandra HakeWe're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social! register here for the entire series: us06web.zoom.us/webinar/regi...
- Reposted by Sandra HakePlease re-post: If you know (or are!) somebody who might fancy doing a PhD (Oct 2026 start) in my group @oxfordbiochemistry.bsky.social, working on chromatin evolution in prokaryotes (or other things we're interested in), please have a look at www.bioch.ox.ac.uk/supervisors-...
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- Reposted by Sandra HakeEvery so often, a paper lands at exactly the right moment. This one’s a gem. Can’t wait to try out this new strategy for delivering CRISPRoff chromatin-editing tools into our favorite cellular model system. Congrats to James K Nuñez and his team: www.nature.com/articles/s41...
- Reposted by Sandra HakeOne more movie! Using the RL algorithm (from pnas.org/doi/10.1073/...), @masaashimazoe.bsky.social analyzed our nucleosome tracking data and classified them by their mobility. Hotter color = faster motion (Slow🔵→ 🟢 → 🟡 → 🟠 Fast)
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If you like transcription regulation and its mechanisms, this WIP list is for you. I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list. go.bsky.app/8vTgeXBat://did:plc:y655pqb5a3etnlz62iqgck5d/app.bsky.graph.starterpack/3lxhl3qh3ay2d - Excited to share our newest results on ZNF512B: It not only regulates chromatin organization, binds NuRD and H2A.Z, and acts as transcriptional repressor (Wunderlich et al., NAR, 2024), it also participates in mitosis and is crucial for stem cell differentiation. www.biorxiv.org/content/10.1...
- Reposted by Sandra HakeThis preprint is now a published peer-reviewed paper! Thanks to all the co-authors involved, to the funders and to @reviewcommons.org and @embopress.org @emboreports.org for a smooth editorial process! Excited to see this in press! www.embopress.org/doi/full/10.... @imperiallifesci.bsky.social
- Congratulations, Dr. Kalita!!!
- Join us!!!!! THE Symposium for all Chromatin and Epigenetics experts and 'lovers' this year!!!
- 🎉 Join us at the upcoming GfG Symposium "Epigenetics & Chromatin" in Giessen, Sept 24–26, 2025! Amazing speakers, low registration fee, € 300 prizes for best poster & short talk, + free GfG membership for non-members. Please RT! express.converia.de/frontend/ind...
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- Elisabeth-Gateff Award Alert! Great opportunity for all German PhDs or PhDs, who worked on their thesis in Germany: 3.000 € award for best thesis in the area of genetics/epigenetics/molecular biology! Apply till June 30th, 2025! Please RT!
- What a fantastic achievement! @jlugiessen.bsky.social got three excellence clusters! Many congratulations to all organisers! Extremely happy about the continued success of @cpi-exstra.bsky.social. I am overjoyed to be a – small - part of this cluster with its amazing team of researchers!
- Join us!!!
- As organizer, I can highly recommend this Symposium! Come and join us! Please RT!
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- Exciting times ahead! We visited the laboratories and offices that we will be moving into at the end of this year after complete renovation (still a lot to do). Thank you @jlugiessen.bsky.social for finding a new home for us!
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- Reposted by Sandra HakeUkraine is Europe! We stand by Ukraine. We will step up our support to Ukraine so that they can continue to fight back the agressor. Today, it became clear that the free world needs a new leader. It’s up to us, Europeans, to take this challenge.
- Finally! The outstanding review by Felix Diegmüller(@felixdiegmueller.bsky.social) & Jörg Leers is out in JBC! Written for a special issue honoring C. David Allis, it highlights his groundbreaking work on histone variants and recent discoveries in H2A.Z biology! #Epigenetics #Histones #Chromatin
- Reposted by Sandra Hake*Tenured full Professorship in Genetics and Molecular Cell Biology* at the University Of Cologne, Germany It's an opportunity to rebuild the place that used to be home to luminaries including Benno Müller-Hill, Max Delbruck, Campos-Ortega, Diethard Tautz Maria Leptin, Thomas Langer
- We are doing our best! Hope the vast majority of Germans has not forgotten our dark past and how everything started… Never again!!! Really scared about what is happening in the USA right now.
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- Reposted by Sandra Hake!THREE OPPORTUNITIES TO JOIN US! We are looking for 3 (!!!) PhD students interested in: How Metabolism affects Genome Regulation. Join us at @carrerasijc.bsky.social as Marie Sklodowska Curie network fellow. More info: 2 x experimental: www.nuclear-dn.eu 1 x computational: www.hubmol.eu
- Together with more than 13.000 people, my husband (mirrored in my sun glasses) and I were demonstrating in the city Gießen against right extremism and hate but for inclusion and equality. There is still hope in a crazy world!
- Reposted by Sandra HakeIn our new paper, we uncover a damaged chromatin marking mechanism that drives the non-random segregation of UV damage through mitosis. Chromatin alterations impinge on genome stability by controlling DNA damage segregation See Ferrand*, Dabin* et al., Nat Commun 2025.
- Reposted by Sandra HakeOur latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin? By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient! #chromatin #3Dgenome #generegulation www.science.org/doi/10.1126/... 👇
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- Reposted by Sandra HakeOur collaboration with the Muir lab revealed that N-terminal histone modifications can 'detoxify' K27M inhibition by altering PRC2-substrate interactions. Acetylation showed the greatest impact, supported by xenograft data from the Monje group. pubs.acs.org/doi/epdf/10....
- Reposted by Sandra HakeA mechanism for maintaining and spreading H3K9me3 in heterochromatin from the Fejes Toth and Aravin labs that depends on the local H3K9me3 density: HP1 dimers recruit SetDB1 to chromatin by simultaneously binding H3K9me3 on histone H3 and auto-methylated SetDB1. www.biorxiv.org/content/10.1...
- Our group has a new Dr. rer. nat.! 🎉 Tim Wunderlich defended his excellent dissertation on ZNF512B with distinction. This fantastic achievement was afterwards celebrated appropriately with colleagues, friends, examiners and family! Congratulations, Dr. Wunderlich! We are so proud!
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- Reposted by Sandra Hake✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨ 📄 Check it out here: doi.org/10.1101/2025... 👇 Highlights below
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