In a new study, FMI researchers show that two enzymes—KDM2A and KDM2B—act as safeguards in eggs, preventing excessive DNA methylation at gene regions. Without them, abnormal methylation is passed to embryos, repressing genes needed for early development.
www.cell.com/developmenta...
Preventing CpG hypermethylation in oocytes safeguards mouse development
Kawamura et al. show that H3K36me2 removal by the KDM2A and KDM2B histone demethylases
restricts DNMT3A in establishing global DNA methylation in oocytes. Maternal Kdm2a/Kdm2b
knockout embryos die dur...
