Jop Kind
Scientist/PI Hubrecht Institute. Exploring gene regulation in early development and cancer. Single-cell spatial genome organization & epigenomics
- Reposted by Jop KindNow out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake! rdcu.be/e1bBW
- Reposted by Jop KindThere are still spots available for our Hubrecht Symposium 2026, taking place on Thursday March 26! 📝 Abstract submission deadline: February 1st. 🎟️ Registration deadline: February 15th. Learn more and register 👇 www.hubrecht.eu/hubrecht-sym...
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- Reposted by Jop KindLooking to start your lab in generative biology / AI? Come join us at the @sangerinstitute.bsky.social Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways! pls RT tinyurl.com/GenGenFaculty
- Reposted by Jop Kind1/ 🧬 Very excited to share our work on dissecting imputation strategies for single-cell histone modification data! academic.oup.com/nargab/artic... A huge thank you to @robinhweide.bsky.social, @jopkind.bsky.social and Jeroen de Ridder for their collaboration in this project!
- 1/ 🧵 I am excited to share a new preprint from our group: Single-cell Dam&T-seq during mouse corticogenesis reveals how genome–lamina interactions regulate long neuronal genes. doi.org/10.1101/2025... #Neurodevelopment #Epigenetics @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social
- 2/ Using in utero electroporation + scDam&T-seq, we jointly profiled transcriptomes and lamina-associated domains (LADs) in embryonic cortex. We found widespread lamina reorganization during differentiation, strongly enriched at long neuronal genes (≥100 kb).
- 3/ These long neuronal genes often detach from the nuclear lamina before activation, suggesting lamina release is an early regulatory step in corticogenesis. This spatial reorganization aligns with their role in neurodevelopmental disorders, including ASD.
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View full thread6/ Together, our work links nuclear architecture, epigenetic state, and MeCP2 activity to the spatiotemporal control of long neuronal genes. With implications for understanding Rett syndrome and broader mechanisms of cortical development. Great collaboration with Basak (UMC Utrecht) team 🧵//
- Reposted by Jop KindJoin this year's CSH Asia Systems Biology of Gene Regulation & Genome Editing meeting in beautiful Suzhou, China, Oct 20-24. Let's bring the international communities together! Abstract deadline Sept 19! Infos and registration at csh-asia.org?content/2767. Please repost!
- Very proud of Kim to be featured by MIT Technology Review as one of this year's innovators under 35 for her pioneering work on mapping DNA repair in single cells! @oncodeinstitute.bsky.social @hubrechtinstitute.bsky.social
- Kim de Luca, Hubrecht alumna from the Kind group, was featured by MIT Technology Review in this year's Innovators Under 35! Swipe to read more. The full list can be found here: technologyreview.com/innovators-under-35….
- Reposted by Jop KindNew preprint with @gfudenberg.bsky.social We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding. This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇 www.biorxiv.org/content/10.1...
- Reposted by Jop KindThis is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇
- Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...
- Reposted by Jop KindExtensive differences observed in 3D genome structure between homologous heterozygous chromosomes revealed by Genome Architecture Mapping #GAM in the @apombo1.bsky.social lab ➡️ www.embopress.org/doi/full/10....
- Reposted by Jop KindWe’re looking for curious, innovative science leaders at EMBL Heidelberg! 🔬🧬🦠 Join a vibrant, interdisciplinary community where collaboration and innovation are nurtured at all levels. Take a look at these four open positions 👇
- Reposted by Jop KindWe found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab. www.biorxiv.org/content/10.1... 1/
- Reposted by Jop Kind🧬 Looking for a PhD position in molecular or developmental biology? 🔬 ✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/
- I am very excited to share our latest work where we describe a new method to profile genome-wide chromatin transitions over time in single cells. Great collaborative effort with the van Oudenaarden group @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social www.nature.com/articles/s41....
- Reposted by Jop Kind🧬 How do epigenetic modifications change over time in the same cell? Are they maintained during cell divisions? Researchers from the Kind and Van Oudenaarden groups have found a way to study these types of questions: www.nature.com/articles/s41.... Read more below! 👇 @jopkind.bsky.social
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- Reposted by Jop KindOur paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
- Reposted by Jop KindDelighted that our work on positional memory is now published. We asked how axolotl cells 'know' which part of the limb to regenerate after injury. www.nature.com/articles/s41... A joy to work with super team Sarah Plattner, Yuka Sugiura, Francisco Falcon and Elly Tanaka. 🧵1/14
- Reposted by Jop Kind🧬What makes one cell different from another? Kim de Luca developed methods that help answer this question. They can be used to study DNA organization, regulation and repair in single cells. Today she successfully defended her thesis. Congratulations Kim!🎓 Read more 👉 www.hubrecht.eu/phd-kim-de-l...
- Reposted by Jop KindToday, on ‘Be Open about Animal Research Day’, we spotlight how research with zebrafish brings us closer to healthier hearts. #BOARD25 Sharing about 80% of heart disease–causing genes with humans, the zebrafish is an excellent model to study how hearts develop, become diseased and might regenerate.
- Reposted by Jop Kind🚨 Preprint 🚨 Ever wondered how cells prepare their genomes to enable new cell-fates? In this team up with the Kind lab, we show that genes are repositioned in the nucleus to get ready for future activation and tissue formation. Read 🧵👇 to find out how and when this happens! doi.org/10.1101/2025...
- Very excited to share our latest work revealing a prominent role for LADs in commisioning cell fates in mouse organ & tissue development, particularly of the limb. Amazing work by Isabel and Samy together with @stemundi.bsky.social & @drmrobson.bsky.social www.biorxiv.org/content/10.1...
- This year I am climbing the alpe d’Huez by bike 6 times to raise money for cancer research. 100% of the funds are directly invested into cancer research. Please click on the link below if you wish to fund this cause and help me reach my goals. Thanks! www.opgevenisgeenoptie.nl/fundraisers/...
- Reposted by Jop KindJoin our team as a postdoc and explore the exciting world of transposable elements and developmental biology with us! @imbavienna.bsky.social @vbcscitraining.bsky.social
- Reposted by Jop KindWe challenged our researchers to describe their work in 10 words or less. See how they did in this video!
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- Reposted by Jop KindWe closed today with a great keynote by @embo.org director Fiona Watt, highlighting how spatial maps of epidermal cell populations have allowed the generation and testing of new hypotheses. Thanks for joining the #HubrechtSymposium2025! We hope you leave with fresh insights and new connections.
- Reposted by Jop KindToday is the first annual #HubrechtSymposium2025! Director Geert Kops opened the meeting and discussed this year’s theme: Developmental Biology - Morphogenesis and cell fate decisions. We're excited for an engaging day of talks and discussions.
- Reposted by Jop KindDuring his keynote, Ben Simons explained how spermatogenesis helps understand stem cell regulation. Feedback mechanisms allow cells to reversibly switch between renewal and differentiation states. After two inspiring sessions, it was time for an interactive poster session. #HubrechtSymposium2025
- Reposted by Jop KindJoin us for the 2025 GRC Genome Architecture www.grc.org/genome-archi... @spp2202.bsky.social @jobdekker.bsky.social @metorrespadilla.bsky.social @jopkind.bsky.social @dimplenotani.bsky.social @stanleyqilab.bsky.social @andybelmont.bsky.social @fondufemittendorf.bsky.social @boyanbonev.bsky.social
- Reposted by Jop KindSAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026. Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute). www.embl.org/about/info/c...
- Reposted by Jop KindEpigenetics Gordon Research Conference. Consider joining us for what will be an excellent, exciting meeting and will be held in Europe for the first time: 10-15 Aug25 Barcelona, Spain. Please repost and apply early - this meeting is popular! www.grc.org/epigenetics-...
- Reposted by Jop KindWhat do long-range enhancers need to regulate genes? Researchers from the De Laat group have found that long-range enhancers require optimal regulatory protein levels, in addition to the specific protein complex cohesin, to switch on genes. Read more here: www.hubrecht.eu/long-range-e...
- Reposted by Jop Kind*Tenured full Professorship in Genetics and Molecular Cell Biology* at the University Of Cologne, Germany It's an opportunity to rebuild the place that used to be home to luminaries including Benno Müller-Hill, Max Delbruck, Campos-Ortega, Diethard Tautz Maria Leptin, Thomas Langer
- Reposted by Jop KindProgram is out for our first EMBL #singlemolecule gene regulation meeting! Check out the dedicated panel sessions on single molecule genomics, single molecule imaging and theory where we would like to brainstorm the future of the field: Registration is open! 👇 www.embl.org/about/info/c...
- Reposted by Jop Kind𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
- Reposted by Jop KindHow do cells find their place in a developing embryo? Scientists have long wondered. A new study by the Hiiragi group uncovers how embryos achieve precise cell organization. Curious what breadcrumbs have to do with this? @prachitimoghe.bsky.social explains it here: www.hubrecht.eu/breadcrumb-t...
- Reposted by Jop KindWant to start an independent research group? ...with core funding, outstanding facilities & a curiosity-driven culture? Join us at @embl.org We are recruiting across research themes, inc (epi)genomics, human dev bio, predictive modelling & neurobiology👇 embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
- Reposted by Jop KindOur Center for Molecular Medicine (cmmutrecht.eu) at UMC Utrecht, NL, is looking for a Principal Investigator in the field of fundamental Cancer Biology! The vacancy states tenure track level, but candidates with a more advanced career are very welcome to apply. shorturl.at/KZeYQ. Please repost!
- We are closing the registration for abstracts soon. We highly encourage PhD students and postdocs to sign-up for a short talk!
- The Hubrecht Symposium is coming up soon! Registration is open until February 20th, submit your abstracts for talks and posters by February 13th. Join this inspiring day on the topic of developmental biology - morphogenesis and cell fate decisions! hubrecht.eu/hubrecht-symposium-2025/registration/
- Reposted by Jop KindWe have 7 projects available for undergrad & master students interested in #AI, #chromatin and #epigenetics. 🧬The Chromatin Dynamics and Epigenetics Lab, led by @robertife.bsky.social, will host an intern during this summer. 🤩Do you want to be her/him? 👉 www.helmholtz-munich.de/en/epigeneti...
- Reposted by Jop KindOur new paper showing how loss of the nuclear pore protein TPR leads to activation of an inflammatory gene expression programme in senescence is now published in eLife: bit.ly/4h1VcFi @wbickmor.bsky.social @uoe-igc.bsky.social @elife.bsky.social
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- A new review from our group on the implementation of single-cell epigenomics in cancer research. A hitchhiker's guide for the use of both wet- & drylab methods. A big shout-out to Marta and Isabel! doi.org/10.1002/ijc....
- Reposted by Jop Kindwww.biorxiv.org/content/10.1... Our study published today on #bioRxiv describe the identification of a deaminase that converts 5mC to T, enabling direct sequencing of the human methylome and genome. This achievement was made possible through a collaborative effort across all departments at #NEB.
- Reposted by Jop KindLooking for a PhD position? Interested in understanding gene regulation using live-cell single-molecule imaging technologies? Apply for the NKI PhD program to join our lab or other NKI labs. bit.ly/3O4bOjq
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- Reposted by Jop KindThe international Curie « Noncoding Genome » course has been revamped! 👉 Dark genome in cell plasticity and heterogeneity. A session on TEs #TEsky with M.E. Torres Padilla, D.Trono and @aktast.bsky.social. Master, PhD and postdoc fellows, a week in Paris during the Spring? Apply before Feb 15th 📌
- I am really happy to announce the first Hubrecht Symposium on March 13th 2025! We will organize these yearly events on a specific topic in molecular and developmental biology to emphasize the importance of fundamental research for Dutch science. Free of charge! www.hubrecht.eu/hubrecht-sym...
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- Reposted by Jop KindHere it is! Congratuations to @jesskelley.bsky.social @edimitrova.bsky.social @neilblackledge.bsky.social @aleksszczurek.bsky.social and the rest of the team (Maciej, Amy, and Hieu). This was a fab collaboration with Arminja Kettenbach. Also see a lovely complementary paper from Fei Chen's group.
- Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)
- Very excited to see our work on genome-wide mapping DNA repair in single cells out @naturecomms.bsky.social Amazing work by Kim de Luca & Pim Rullens. Wonderful collaboration with the Legube lab, @mariekeoudelaar.bsky.social & @jjachowicz.bsky.social . rdcu.be/d0ZAM
