Pierre Bourguet
Biologist studying transposons, gene regulation and chromatin in the Jullien group.
Postdoc @ IBMP (Strasbourg, France).
@ibmp-cnrs.bsky.social
- Reposted by Pierre Bourguet[Not loaded yet]
- Reposted by Pierre Bourguet'The Centre for Research in Cellular Biology of Montpellier (CRBM) is recruiting Junior/Senior Group Leaders to shape its research in the coming decade. The deadline for application is 31st of March 2026.' #sciencejobs focalplane.biologists.com/cell-biology...
- Reposted by Pierre BourguetHere we go again! Join us in Vienna, May 21–22, for two days of plant science—talks, discussions, and celebration of what makes plants both beautiful and essential 💚Full program + registration here: www.oeaw.ac.at/gmi/news-eve... Come be part of it — each of you counts!
- Reposted by Pierre BourguetI am excited to offer a postdoctoral research position in my lab in Oxford studying the distribution of small RNAs during plant sexual reproduction. shorturl.at/7Goxt Reposts appreciated! Obligatory cat video to brighten your day. :-)
- Reposted by Pierre Bourguet📢 Three new #bioRxiv preprints from our team on holocentric chromosomes. Together, they connect centromere repeat evolution, karyotype dynamics, and meiotic recombination outcomes, revealing how holocentric genomes evolve and function. 🧬👇
- Reposted by Pierre BourguetDominant contribution of Asgard archaea to eukaryogenesis. tldr; Best guess, ~ 50% of conserved eukaryotic protein families are from from Asgard archaea! #science #biology #evolution #nature #bioinformatics www.nature.com/articles/s41...
- Reposted by Pierre BourguetAfter a short break in our webinars we are delighted to be back up & running this month! First up, on Jan 30th we will be joined by @lucas.farnunglab.com from @harvardmed.bsky.social 🔬 Shortly after, on Feb 13th we will be hosting @heardlab.bsky.social from @crick.ac.uk 🧬 Registration details 👇
- Reposted by Pierre BourguetThe (Yoav) Voichek lab has opened its gates at the Weizmann Institute, and is actively recruiting students and researchers at all levels - come explore gene regulation and computational genomics in a fun, friendly sprouting lab 🤗🥼⚗️🧪 www.weizmann.ac.il/plants/voichek
- Reposted by Pierre BourguetNew Year, New Paper!🎊 Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system www.biorxiv.org/content/10.6... Centerpiece of Jason Chobirko's PhD, talented PhD student co-mentored by Andrew Grimson & me. Really excited about it!🧵
- Reposted by Pierre BourguetHave we been overstating the role of transposable elements in adaptation to local or rapidly changing environmental conditions? Happy to share my (somewhat unpopular?) opinion paper on this matter: www.sciencedirect.com/science/arti... Thanks to those who already shared the link!
- Reposted by Pierre BourguetREFEREE 1: “I conclude with a simple, direct statement - this is the best paper I have read all year!” #TransparentPeerReview Co-evolving infectivity and expression patterns drive the diversification of endogenous retroviruses @juliusbrennecke.bsky.social et al www.embopress.org/doi/full/10....
- Reposted by Pierre BourguetIntrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway. And found a hidden RNA-decay axis from Piwi to the RNA exosome.
- RNA decay via the nuclear exosome is essential for piwi-mediated transposon silencing biorxiv.org/content/10.64898/20…
- Reposted by Pierre BourguetApplications for our international #PhD program open until 11th Jan. Come work with us @uoe-igc.bsky.social and @hannahlong.bsky.social to understand DNMT3B in ICF syndrome or with our wonderful colleagues. Details here: institute-genetics-cancer.ed.ac.uk/igc-graduate... #epigenetics Please repost 🙏
- Reposted by Pierre BourguetWhile stories of singular DNA changes that drove evolution of human brain/behaviour remain seductive, advances across multiple fields of biology cast doubt on such simplistic narratives of our origins. A new paper from my lab shows how biobanks may speak to this fundamental question.🧪 Explainer🧵👇1/n
- Reposted by Pierre BourguetClosing out my year with a journal editor shocker 🧵 Checking new manuscripts today I reviewed a paper attributing 2 papers to me I did not write. A daft thing for an author to do of course. But intrigued I web searched up one of the titles and that's when it got real weird...
- Reposted by Pierre BourguetAujourd'hui c'est le solstice d'hiver dans l'hémisphère Nord. Les journées vont commencer à rallonger! Le soleil ne se lève à l'Est (centre de l'image avec Nord à gauche, Sud a droite) que lors des équinoxes. La position du lever change un peu tous les jours! (©Z. Al-Abbadi)
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- Reposted by Pierre BourguetHave you ever wondered how new DNA methylation patterns are established? Paradigm shift ahead! We discovered a new mode of DNA methylation targeting in plants that relies on transcription factors and sequence motifs rather than chromatin modifications to regulate the methylome. rdcu.be/eQ6L5 1/8
- Reposted by Pierre BourguetAn early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost! www.biorxiv.org/content/10.6...
- Reposted by Pierre BourguetTransposable elements can insert into genes, disrupting protein-coding potential. Researchers discover a mode of RNA processing, ‘SOS splicing’, that provides a quick fix @nature.com @harvardmed.bsky.social www.nature.com/articles/d41... www.nature.com/articles/s41...
- Reposted by Pierre BourguetLooking for a postdoc in computational biology? We are looking for a postdoc candidate apply for the fellowship 'Juan de la Cierva' for a project on long-read transcriptomics, multiomics, spatial transcriptomics, single-cell long-reads. Deadline is approaching!! (December 10th)
- Reposted by Pierre Bourguet🔬 Call to create junior research groups at the Institut Pasteur Focus: Infectious diseases, host-microbe interactions, vaccines Special interest: AI methodologies 📅 Deadline: Feb 9, 2026 👥 2-12 years post-PhD Apply now 📝 research.pasteur.fr/en/call/crea... #JobOpportunity #Research
- Reposted by Pierre BourguetPreprint alert! It is my great pleasure to announce the first manuscript from the lab, a story that started @gmivienna.bsky.social and was mainly accomplished by the intrepid @gesahoffmann.bsky.social at @mpi-mp-potsdam.bsky.social. A brief thread with our findings www.biorxiv.org/content/10.1...
- Reposted by Pierre BourguetHave you ever wondered how it is possible that systemically infected plants produce (a certain percentage of) healthy progeny? 💚 Check out the first preprint of the @incavirus.bsky.social lab and first preprint of my postdoc! 🍀 We'd be very happy about feedback and discussions!
- Preprint alert! It is my great pleasure to announce the first manuscript from the lab, a story that started @gmivienna.bsky.social and was mainly accomplished by the intrepid @gesahoffmann.bsky.social at @mpi-mp-potsdam.bsky.social. A brief thread with our findings www.biorxiv.org/content/10.1...
- Reposted by Pierre BourguetHow to keep in step when your (protein) partner speeds up… Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection. Congrats to whole team! www.science.org/doi/10.1126/...
- Reposted by Pierre BourguetPaper alert! We have created a bacterium that eats plastic! We named it PETBuster! Great work by PhD student Dekel Freund @dekel-freund.bsky.social. www.biorxiv.org/content/10.1...
- Reposted by Pierre BourguetNew preprint from our group led by @metalichen.bsky.social on the discovery of a Starship giant transposable element in the genome of a lichen-forming fungus.
- New preprint: 🚀🧬 Starship in the genome of the lichen fungus Xanthoria. Discovery of giant transposons Starships challenged what we thought we knew about fungal genomes. But what about Starships in #lichen fungi? Let us present Tangerine! 🖥️ 🧪 🦠 🧫 #SymbioSky doi.org/10.1101/2025...
- Reposted by Pierre BourguetOut today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
- Reposted by Pierre BourguetStill looking for our perfect doctoral candidate as part of @evomg-dn.bsky.social - come and join us to work on the evolutionary pressures that shape gene expression and disease in the uterus! Please RT (or is it RB? not sure how our lingo has changed!)
- 🚨 15 days left to apply! Be part of EvoMG-DN and advance your PhD career in evolutionary genomics. 👉 www.evomg-dn.eu #PhD #DoctoralTraining #ResearchCareers #LifeSciences #BiomedicalResearch #Genomics #EvolutionaryBiology #MSCA #HorizonEurope #EUResearch #ResearchOpportunities #PhDPositions
- Reposted by Pierre BourguetOur nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems: www.science.org/doi/10.1126/... Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
- Reposted by Pierre BourguetHaving a lot of fun at #EMBOMobileGenome 😃 Perfect timing for our paper from the lab of @toddmacfarlan.bsky.social to be out @natcomms.nature.com!! …and I’m currently on the job market looking for a new scientific home! www.nature.com/articles/s41...
- Reposted by Pierre Bourguetwww.biorxiv.org/content/10.1... @soreklab.bsky.social Sorek lab does it again! Such a cool signal to specifically detect the event of genome degradation by a phage
- How is epigenetic information inherited? We found that CDCA7 proteins are critical players in the inheritance of DNA methylation at CG sites in plants, and this is true both in the lab and in the wild. How does this work? 🧵👇
- New paper! Work led by @p-bourguet.bsky.social and Frédéric Berger at the GMI of the @oeaw.bsky.social and @esasaki007.bsky.social identified how protein CDCA7 helps plants stably maintain epigenetic modifications across generations. Read more: www.oeaw.ac.at/gmi/detail/n...
- This paper coming out today is a beautiful way for me to close up the #EMBOmobilegenome in Heidelberg. Great crowd, great talks, great things ahead! Shoutout to the organizers for putting this together 👏
- Reposted by Pierre BourguetSome impressions from the rather fabulous #EMBOmobilegenome Mobile Genome meeting in Heidelberg Morning walk through the woods, exciting panel discussion, flash talks, lab community, drosophila friends, … @events.embl.org The transposon community is going very strong. see you all again in 2027!!
- Reposted by Pierre Bourguet🚨 First pre-print from my team !! TL;DR: presence of polymorphism (sequence differences between the homologous chromosomes) can *increase* the local rate of recombination in Arabidopsis thaliana, turning cold regions of the genome hot (purple v. grey) !
- Reposted by Pierre BourguetHappy to share the results of a long-haul post-doc project, now online @science.org, aiming at understanding the rules of transgeneration epigenetic inheritance over TEs in plants and its extent and impact in nature. More below! doi.org/10.1126/scie...
- Reposted by Pierre BourguetMy first first-author paper is out!🎉 Here we propose a model where a silencing complex, PIWI*, assembles on target RNAs to recruit effectors and shut down transposon activity. Huge thanks to the Brennecke and Plaschka labs, especially Julius and Clemens, and all co-authors!
- PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity. But how does piRNA-guided target interaction translate into silencing? PhD student Júlia Portell Montserrat has an intriguing answer www.cell.com/molecular-ce...
- Reposted by Pierre Bourguet🚀 Checkout our new #nextflow MNase-pipeline nucDetective Features: ✅ MNase QC analysis ✅ high resolution nucleosome maps ✅ detect nucleosome dynamics ✅ multi-condition comparison ✅ nucleosme-repeat-length Try it here: github.com/uschwartz... 1/2
- Reposted by Pierre BourguetBOKU University in Vienna is recruiting a full professor for Biochemistry! Check out the description below, apply and join us in beautiful Vienna. @bokuvienna.bsky.social 🧪🧪🧪 short.boku.ac.at/53e6g6
- Reposted by Pierre BourguetFurther evidence that sugar in the plates changes the plant biology you study. Best to avoid putting sugar in the agar, unless you want to study what sugar in the agar does to plants. This paper uses sugar in the agar to study what sugar does. www.nature.com/articles/s41... #plantresearch
- Reposted by Pierre BourguetAttention plant proteomics specialists: We are looking for a Head of our new Proteomics Unit at our international and dynamic Max Planck Institute of Molecular Plant Physiology. @mpi-mp-potsdam.bsky.social Applications are welcome until 30. Sept 2025: jobs.mpimp-golm.mpg.de/jobposting/8...
- Reposted by Pierre BourguetThanks for sharing! All activities were spearheaded by Roberto Torres @lcatmon.bsky.social in collaboration with the "44 Perills" association and with the support of @sesbe-org.bsky.social @eseb2025.bsky.social and @ajuntamentbcn.bsky.social. Big shout out to #eseb2025 scientists that participated!
- Surely one of the all-time best conference outreach activities: an evolution-inspired decorated street for Les Festes de Gràcia #ESEB2025
- Reposted by Pierre BourguetAugust’s Nature Plants cover story shows how we integrated large-scale multiDAP and snRNA data to reveal drivers of cell type identity and evolution in flowering plants. www.nature.com/nplants/volu... We packed a lot into this paper! Here’s a single-cell spin on what we found:
- Reposted by Pierre BourguetOut after peer review, collaborative study from Nordborg & Weigel labs with help from many others. Not the largest collection of new Arabidopsis thaliana genomes, but we hopefully put forward some good ideas for how to think about pangenomes and their analysis! www.nature.com/articles/s41...
- Reposted by Pierre BourguetThrilled to have our spatial single-cell atlas of the Arabidopsis lifecycle in @NaturePlants. Turns out that its easy to make nice images when spatial expression of 1,000 genes is available! 1/n @natanellae.bsky.social @tatsuyanobori.bsky.social @joeecker.bsky.social www.nature.com/articles/s41...
- Reposted by Pierre Bourguet🌱 come join our lab 😀 🔬 PhD: small RNAs & plant stress (36 mo) 🧬CDD researcher: plant molecular biology (24 mo) Apply 👇 PhD: emploi.cnrs.fr/Offres/Docto... CDD: emploi.cnrs.fr/Offres/CDD/U... #PlantScience #PhD #ResearchJobs#ERC#CNRS
- Reposted by Pierre BourguetVery proud of this work where we define how the MORC2 ATPase directs CpG methylation of active human L1 transposons in early development. Thanks to co-authors, funders & wonderful environment @lundstem.bsky.social www.biorxiv.org/content/10.1... Brief thread below (do people still do that?) 1/X
- I can only recommend working with Heïdi at the GReD, she is a terrific scientist and human being! Clermont-Ferrand has high quality of life, is affordable and the surrounding nature is a beauty.
- Reposted by Pierre Bourguet1/7 I am very excited to announce our🌹NEW PAPER OUT IN 𝑁𝐴𝑇𝑈𝑅𝐸!🌹 𝐃𝐑𝐈𝐕𝐄 𝐓𝐎 𝐒𝐔𝐑𝐕𝐈𝐕𝐄: Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis With the Ritz and Kovařík labs we show a potential role for centromeres on 𝘙𝘰𝘴𝘢 𝘤𝘢𝘯𝘪𝘯𝘢 bizarre reproduction! www.nature.com/articles/s41...
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- Reposted by Pierre BourguetThe rest of Mendel's alleles characterized! So, out of 7 traits, 3 caused by TE insertions!!! (though apparently there are two different green alleles, one cause by a TE insertion, but another a promoter deletion allele) www.nature.com/articles/s41...
