Misha Zilberter
Neuroscientist at Gladstone Institutes /UCSF: electrophysiology & hippocampal network function, APOE4, and glucose metabolism in Alzheimer’s disease
ORCID: 0000-0001-7164-8312
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- Reposted by Misha ZilberterExcited to share newly minted PhD Anu Korukonda's tour de force thesis work describing the impact of pathogenic tau on #locuscoeruleus function in a mouse model of early #Alzheimers. A must for #BlueSpot researchers! www.biorxiv.org/content/10.6... 1/3
- Reposted by Misha ZilberterBecause of technical issues with the SciENcv website, NIH is extending a period of leniency accepting old format biosketches through May 2026 (see FAQ #5): grants.nih.gov/faqs#/common...
- Reposted by Misha ZilberterOur paper is (finally) out in Cell today! CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis www.cell.com/cell/fulltex... Great collaborative effort - read more from first author @asamelson.bsky.social below:
- After a long review process, I'm excited that our paper is finally in print: www.cell.com/cell/fulltex... TL;DR: We use CRISPR screens in iPSC-derived neurons to find a new tau E3 ligase and a relationship between oxidative stress, the proteasome, and tau proteolytic fragments. More below 👇
- Reposted by Misha ZilberterNew work from our lab! Link: rdcu.be/e0sfU 𝗧𝗮𝘂 𝗛𝗶𝗷𝗮𝗰𝗸𝘀 𝗕𝗿𝗮𝗶𝗻 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺, 𝗗𝗿𝗶𝘃𝗶𝗻𝗴 𝗦𝗹𝗲𝗲𝗽 𝗟𝗼𝘀𝘀 𝗶𝗻 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲 A quick thread on our findings!
- Reposted by Misha ZilberterExcited to be on the organization meeting for the 6th annual NCM conference on Neural Circuits in Health & Disease. Terrific line up of speakers!
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- Reposted by Misha ZilberterHappy to announce the 2nd Hippocampus Green Meeting 📍 Barcelona, Spain 🗓️ May 11–12, 2026 Organized together with Manu Valero, Lisa Roux and Dan Bendor 🎤 Keynotes: Nachum Ulanovsky & György Buzsáki ‼️ Call for abstracts now open 🔗 hippocampusgreen.net/wp/ #HippocampusGreen
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- Cracking open a celebratory bottle of brandy with our first author, Dennis, to mark the paper’s acceptance. Moments like this make it all worth it.
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- Another great preprint on neuronal APOE4 from the Huang lab!
- Reposted by Misha ZilberterOur new review is out today! 𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀 We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility. onlinelibrary.wiley.com/doi/10.1111/...
- Reposted by Misha ZilberterApolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes - Al‐Amin - 2025 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
- Mitochondrial bioenergetic signatures differentiate asymptomatic from symptomatic Alzheimer’s disease: www.biorxiv.org/content/10.1...
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- Reposted by Misha Zilberter⚠️SAVE THE DATE⚠️ 🧠CAJAL CONFERENCE 2026 📍Cádiz, April 15–17 “Novel Insights into Brain Energy Metabolism in Health and Disease” Join an outstanding lineup of keynote speakers!👇🏻
- Submitted reviews for the upcoming NIA study section (hasn't been cancelled yet). Looks like I was the only one....
- Reposted by Misha ZilberterWhile you are all waiting for treat or treaters & the blue jay game … take a look at our newest from @bonniee-leee.bsky.social where we look at neural networks in middle aged female rats based on APOE genotype and parity history www.sciencedirect.com/science/arti...
- Reposted by Misha Zilberter🚨New in Lancet Neurology: Autopsy study of aducanumab in #Alzheimer’s shows superficial cortical Aβ cleared, but deeper persists. ARIA showed inflammation+ microinfarcts in leptomeningeal/penetrating vessels. Some path is PET-invisible. @drneurochic.bsky.social authors.elsevier.com/a/1lxn85FFzL...
- Reposted by Misha ZilberterBIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
- Lactate transport via glial MCT1 and neuronal MCT2 is not required for gamma oscillations and sharp wave-ripples in hippocampal slices supplied with glucose. onlinelibrary.wiley.com/doi/10.1111/...
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- Reposted by Misha ZilberterThrilled to share that our paper “Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer’s disease” is now out in Molecular Neurodegeneration! 👉 link.springer.com/article/10.1... #Alzheimer #Resilience #Neuroscience
- Reposted by Misha ZilberterOur paper on 'mini analysis' is now published in @jphysiol.bsky.social If you are recording mPSCs or sPSCs, I hope this helps with analysis. Interpretation of these datasets is not as easy as it seems..! Happy to discuss if you are interested physoc.onlinelibrary.wiley.com/doi/10.1113/...
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- C.Elegans neurons use glycogen to sustain synaptic function in times of energy stress: Glycogen supports glycolytic plasticity in neurons | PNAS www.pnas.org/doi/10.1073/...
- Reposted by Misha ZilberterFor #AAIC2025 attendees: #ADRD researcher starter pack! Thanks @tyk314.net for promoting me to share this again go.bsky.app/22DpUEyat://did:plc:nthhl4qewfhxigeaq44do7vm/app.bsky.graph.starterpack/3layxzumm7u2l
- Reposted by Misha ZilberterLooking for a postdoc or staff scientist with brain slice electrophysiology experience. If you or someone you know is interested in, message me.
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- I feel seen
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- Reposted by Misha Zilberter🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...
- Kicking off the inaugural GRC Alzheimer’s disease meeting — excited for the science and the discussions ahead!
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- Reposted by Misha Zilberter#neuroskyence folks: as my postdoc grant is running out soon, I am looking for new opportunities in systems neuroscience! Keywords: patch clamp ephys, opto, mouse behavior, (in vivo) voltage imaging. Would love to return to the Basal Ganglia. Sharing appreciated, and happy #FluorescenceFriday !
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- Reposted by Misha ZilberterAre you looking for a faculty job? We are hiring in my department at Roswell Park NOW. Contact me for details as I await the formal ad. (Please RT.)
- Reposted by Misha ZilberterWhat does the APOE 'lipid droplet-ome' look like??? Check out our new paper to find out! www.sciencedirect.com/science/arti... Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social +help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs
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- Reposted by Misha ZilberterHow does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain 🧠🧬 New paper out in @natcomms.nature.com today: www.nature.com/articles/s41... @ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social
- Reposted by Misha ZilberterExciting work @blurtonjoneslab.bsky.social: CRISPR-engineered iPSC-microglia use the plaque-responsive CD9 promoter to deliver Aβ-degrading neprilysin across the brain-- reducing plaques, inflammation & synaptic loss. A promising new cell therapy platform for AD www.sciencedirect.com/science/arti...
- Thrilled (and honestly relieved) to receive the NOA from NIA for our project to dig deeper into the neuronal mechanisms of APOE4-induced network dysfunction.
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- Reposted by Misha ZilberterHiring! We're looking for a postdoc to join my lab at the @ukdri.ac.uk @ucl.ac.uk We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments. Apply here👇 shorturl.at/LpCAq
- Reposted by Misha ZilberterATTENTION Has anyone received a NOA this week (other than a no-cost extension? Please DM me or respond on signal jeremymberg.78 THANK YOU
