Rik van der Kant
Researcher, all things Alzheimer, brain diseases and lipids
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- Proud to present our new paper in @natmetabolism.nature.com The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases lnkd.in/eVzFrmUY Check out our open-access platform chock-full with iPSC- and 🧠 lipidomics data (www.neurolipidatlas.com).
- Our main conclusions: ➡️ Lipids are changes in multiple brain diseases ➡️ In Alzheimer and ApoE4 astrocytes triglycerides and cholesteryl esters accumulate And, most surprising: ➡️ Altered cholesterol storage in ApoE4 astrocytes suppresses their HLA-immune function
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- Reposted by Rik van der KantOur perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems. @jonykipnis.bsky.social www.nature.com/articles/s41...
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- Anyone going to #adpd and wants to hang out?
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- Reposted by Rik van der Kantnew preprint! www.biorxiv.org/content/10.1... a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!) first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social
- Reposted by Rik van der KantAbstract submissions for #AAICAdvancements: APOE & Lipid Biology, and #Tau2025 close Dec. 6 for ISTAART members! Share your work on APOE’s role in neurodegeneration or tauopathies like PSP, CBD & FTD. Don’t miss out on these two meetings—Submit now! www.alz.org/research/for...
- Reposted by Rik van der KantAbstract submission for Stem Cell Models of Neurodegeneration 2025 is open until January 31st 2025! Come register and share your work with us! scmnd.com We look forward to hosting you in Edinburgh next year :-) #neuroscience #iPSC #neurodegeneration #stemcells #dementia #organoids
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- I also made a starters pack for all Riks working on Tau. Are you a Rik that works on Tau? Comment below and I will add you. bsky.app/profile/did:...
- Reposted by Rik van der KantThis spring, we reported in Nature a therapeutic approach for Timothy syndrome This has been a long journey starting with making hiPS cell-derived neurons in 2D cultured 15 years ago when I was a postdoc & continued with creating in the lab #organoid and then #assembloid models of this disease
- Happy Sinterklaas for all Dutchies! We had a thematic journal club this week!
- For my first post, an invitation to join us in Miami! A lot of thing on ApoE and lipids are moving fast, catch up! Abstract submission is now open!
- Link to the program: www.alz.org/media/Docume... And registration/abstract submission www.alz.org/apoe/overvie...
